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Abstract:

Synchronization of brain activity fluctuations is believed to represent communication between spatially distant neural processes. These interareal functional interactions develop in the background of a complex network of axonal connections linking cortical and subcortical neurons, termed the human "structural connectome." Theoretical considerations and experimental evidence support the view that the human brain can be modeled as a system operating at a critical point between ordered (subcritical) and disordered (supercritical) phases. Here, we explore the hypothesis that pathologies resulting from brain injury of different etiologies are related to this model of a critical brain. For this purpose, we investigate how damage to the integrity of the structural connectome impacts on the signatures of critical dynamics. Adopting a hybrid modeling approach combining an empirical weighted network of human structural connections with a conceptual model of critical dynamics, we show that lesions located at highly transited connections progressively displace the model toward the subcritical regime. The topological properties of the nodes and links are of less importance when considered independently of their weight in the network. We observe that damage to midline hubs such as the middle and posterior cingulate cortex is most crucial for the disruption of criticality in the model. However, a similar effect can be achieved by targeting less transited nodes and links whose connection weights add up to an equivalent amount. This implies that brain pathology does not necessarily arise due to insult targeted at well-connected areas and that intersubject variability could obscure lesions located at nonhub regions. Finally, we discuss the predictions of our model in the context of clinical studies of traumatic brain injury and neurodegenerative disorders. © 2016 Mary Ann Liebert, Inc.

Registro:

Documento: Artículo
Título:Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality
Autor:Haimovici, A.; Balenzuela, P.; Tagliazucchi, E.
Filiación:Departamento de Física, Facultad de Cs. Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Física de Buenos Aires (IFIBA), CONICET, Buenos Aires, Argentina
Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam-Zuidoost BA, 1105, Netherlands
Palabras clave:Anatomic connectivity; brain injury; dynamics; functional connectivity; modeling; Article; brain damage; cingulate gyrus; connectome; middle cingulate cortex; neuropathology; pathological anatomy; posterior cingulate; priority journal; structural connectome; biological model; brain; brain injury; computer simulation; connectome; diffusion tensor imaging; human; nerve cell network; nerve tract; pathophysiology; physiology; procedures; statistics and numerical data; Brain; Brain Injuries; Computer Simulation; Connectome; Diffusion Tensor Imaging; Humans; Models, Neurological; Nerve Net; Neural Pathways
Año:2016
Volumen:6
Número:10
Página de inicio:759
Página de fin:771
DOI: http://dx.doi.org/10.1089/brain.2016.0455
Título revista:Brain Connectivity
Título revista abreviado:Brain Connectivity
ISSN:21580014
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21580014_v6_n10_p759_Haimovici

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Citas:

---------- APA ----------
Haimovici, A., Balenzuela, P. & Tagliazucchi, E. (2016) . Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality. Brain Connectivity, 6(10), 759-771.
http://dx.doi.org/10.1089/brain.2016.0455
---------- CHICAGO ----------
Haimovici, A., Balenzuela, P., Tagliazucchi, E. "Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality" . Brain Connectivity 6, no. 10 (2016) : 759-771.
http://dx.doi.org/10.1089/brain.2016.0455
---------- MLA ----------
Haimovici, A., Balenzuela, P., Tagliazucchi, E. "Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality" . Brain Connectivity, vol. 6, no. 10, 2016, pp. 759-771.
http://dx.doi.org/10.1089/brain.2016.0455
---------- VANCOUVER ----------
Haimovici, A., Balenzuela, P., Tagliazucchi, E. Dynamical Signatures of Structural Connectivity Damage to a Model of the Brain Posed at Criticality. Brain Connectivity. 2016;6(10):759-771.
http://dx.doi.org/10.1089/brain.2016.0455