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Abstract:

The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag. © 2015 Micol Tomaiuolo et al.

Registro:

Documento: Artículo
Título:Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
Autor:Tomaiuolo, M.; Katche, C.; Viola, H.; Medina, J.H.
Filiación:Instituto de Biología Celular y Neurociencias 'Dr. Eduardo de Robertis', Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, C1121ABG, Argentina
Departamento de Fisiología, Biología Molecular y Celular Dr. Hector Maldonado, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, C1121ABG, Argentina
Palabras clave:arc protein; brain derived neurotrophic factor; brain protein; dopamine 1 receptor; dopamine 5 receptor; unclassified drug; activity regulated cytoskeletal-associated protein; cytoskeleton protein; dopamine 1 receptor; dopamine 5 receptor; nerve protein; animal experiment; Article; controlled study; dopaminergic nerve cell; dorsal hippocampus; evidence based practice; exploratory behavior; hippocampus; long term memory; long term potentiation; male; memory consolidation; nonhuman; protein expression; protein synthesis; rat; short term memory; signal processing; training; ventral tegmentum; animal; avoidance behavior; biosynthesis; environment; hippocampus; long term memory; motor activity; physiology; recognition; Wistar rat; Animals; Avoidance Learning; Cytoskeletal Proteins; Environment; Hippocampus; Male; Memory, Long-Term; Motor Activity; Nerve Tissue Proteins; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D5; Recognition (Psychology)
Año:2015
Volumen:2015
DOI: http://dx.doi.org/10.1155/2015/603672
Título revista:Neural Plasticity
Título revista abreviado:Neural Plast.
ISSN:20905904
CODEN:NEPLF
CAS:brain derived neurotrophic factor, 218441-99-7; activity regulated cytoskeletal-associated protein; Cytoskeletal Proteins; Nerve Tissue Proteins; Receptors, Dopamine D1; Receptors, Dopamine D5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20905904_v2015_n_p_Tomaiuolo

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Citas:

---------- APA ----------
Tomaiuolo, M., Katche, C., Viola, H. & Medina, J.H. (2015) . Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage. Neural Plasticity, 2015.
http://dx.doi.org/10.1155/2015/603672
---------- CHICAGO ----------
Tomaiuolo, M., Katche, C., Viola, H., Medina, J.H. "Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage" . Neural Plasticity 2015 (2015).
http://dx.doi.org/10.1155/2015/603672
---------- MLA ----------
Tomaiuolo, M., Katche, C., Viola, H., Medina, J.H. "Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage" . Neural Plasticity, vol. 2015, 2015.
http://dx.doi.org/10.1155/2015/603672
---------- VANCOUVER ----------
Tomaiuolo, M., Katche, C., Viola, H., Medina, J.H. Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage. Neural Plast. 2015;2015.
http://dx.doi.org/10.1155/2015/603672