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Abstract:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available. Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis. In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives. Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis. In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways. Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies. Copyright © 2011 Mario Rafael Pagani et al.

Registro:

Documento: Artículo
Título:Autoimmunity in amyotrophic lateral sclerosis: Past and present
Autor:Pagani, M.R.; Gonzalez, L.E.; Uchitel, O.D.
Filiación:Department of Physiology and Biophysics, School of Medicine, University of Buenos Aires, C1121ABG Buenos Aires, Argentina
Instituto de Fisiología Biología Molecular y Neurociencias UBA-CONICET, Departamento de Fisiología Biología Molecular y Celular, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Laboratorio de Fisiología y Biología Molecular, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II-2do Piso, C1428EHA Buenos Aires, Argentina
Año:2011
Volumen:2011
DOI: http://dx.doi.org/10.1155/2011/497080
Título revista:Neurology Research International
Título revista abreviado:Neurol. Res. Int.
ISSN:20901852
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20901852_v2011_n_p_Pagani

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Citas:

---------- APA ----------
Pagani, M.R., Gonzalez, L.E. & Uchitel, O.D. (2011) . Autoimmunity in amyotrophic lateral sclerosis: Past and present. Neurology Research International, 2011.
http://dx.doi.org/10.1155/2011/497080
---------- CHICAGO ----------
Pagani, M.R., Gonzalez, L.E., Uchitel, O.D. "Autoimmunity in amyotrophic lateral sclerosis: Past and present" . Neurology Research International 2011 (2011).
http://dx.doi.org/10.1155/2011/497080
---------- MLA ----------
Pagani, M.R., Gonzalez, L.E., Uchitel, O.D. "Autoimmunity in amyotrophic lateral sclerosis: Past and present" . Neurology Research International, vol. 2011, 2011.
http://dx.doi.org/10.1155/2011/497080
---------- VANCOUVER ----------
Pagani, M.R., Gonzalez, L.E., Uchitel, O.D. Autoimmunity in amyotrophic lateral sclerosis: Past and present. Neurol. Res. Int. 2011;2011.
http://dx.doi.org/10.1155/2011/497080