Artículo

Rolandelli, A.; Pellegrini, J.M.; Amiano, N.O.; Santilli, M.C.; Morelli, M.P.; Castello, F.A.; Tateosian, N.L.; Levi, A.; Casco, N.; Palmero, D.J.; García, V.E. "The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina" (2018) Genes. 9(1)
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Abstract:

Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Registro:

Documento: Artículo
Título:The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina
Autor:Rolandelli, A.; Pellegrini, J.M.; Amiano, N.O.; Santilli, M.C.; Morelli, M.P.; Castello, F.A.; Tateosian, N.L.; Levi, A.; Casco, N.; Palmero, D.J.; García, V.E.
Filiación:Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Pabellón II, Universidad de Buenos Aires, 4° piso, Intendente Güiraldes 2160, Ciudad Universitaria, Buenos Aires, C1428EGA, Argentina
Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET, Universidad de Buenos Aires, 4° piso, Intendente Güiraldes 2160, Ciudad Universitaria, Buenos Aires, C1428EGA, Argentina
División Tisioneumonología Hospital F.J. Muñiz, Uspallata 2272, Buenos Aires, C1282AEN, Argentina
Palabras clave:Interferon gamma; Mycobacterium tuberculosis; Rs1861494; Single nucleotide polymorphism; Tuberculosis; biological marker; CD4 antigen; gamma interferon; Mycobacterium antigen; adult; allele; Argentina; Article; bacterial strain; case control study; CD4+ T lymphocyte; controlled study; disease resistance; disease severity; female; gene frequency; gene function; gene location; genetic association; genetic variation; genotype; human; human cell; IFNG gene; immune response; major clinical study; male; Mycobacterium tuberculosis; nonhuman; peripheral blood mononuclear cell; single nucleotide polymorphism; tuberculosis
Año:2018
Volumen:9
Número:1
DOI: http://dx.doi.org/10.3390/genes9010046
Título revista:Genes
Título revista abreviado:Genes
ISSN:20734425
CAS:gamma interferon, 82115-62-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20734425_v9_n1_p_Rolandelli

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Citas:

---------- APA ----------
Rolandelli, A., Pellegrini, J.M., Amiano, N.O., Santilli, M.C., Morelli, M.P., Castello, F.A., Tateosian, N.L.,..., García, V.E. (2018) . The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina. Genes, 9(1).
http://dx.doi.org/10.3390/genes9010046
---------- CHICAGO ----------
Rolandelli, A., Pellegrini, J.M., Amiano, N.O., Santilli, M.C., Morelli, M.P., Castello, F.A., et al. "The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina" . Genes 9, no. 1 (2018).
http://dx.doi.org/10.3390/genes9010046
---------- MLA ----------
Rolandelli, A., Pellegrini, J.M., Amiano, N.O., Santilli, M.C., Morelli, M.P., Castello, F.A., et al. "The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina" . Genes, vol. 9, no. 1, 2018.
http://dx.doi.org/10.3390/genes9010046
---------- VANCOUVER ----------
Rolandelli, A., Pellegrini, J.M., Amiano, N.O., Santilli, M.C., Morelli, M.P., Castello, F.A., et al. The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina. Genes. 2018;9(1).
http://dx.doi.org/10.3390/genes9010046