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Abstract:

In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in D. melanogaster. © 2019. Published by The Company of Biologists Ltd.

Registro:

Documento: Artículo
Título:Contribution of non-circadian neurons to the temporal organization of locomotor activity
Autor:Pırez, N.; Bernabei-Cornejo, S.G.; Fernandez-Acosta, M.; Duhart, J.M.; Fernanda Ceriani, M.
Filiación:Laboratorio de Genética del Comportamiento, Fundación Instituto Leloir, Instituto de Investigaciones Bioquımicas –Buenos Aires (IIB–BA, CONICET), Buenos Aires, 1425, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiologıá, Biologıá Molecular y Celular and CONICET, Universidad de Buenos Aires, Instituto de Fisiologıá, Biologıá Molecular y Neurociencias (IFIByNE), Buenos Aires, 1428, Argentina
Unidad de Transferencia Genética, Instituto de Oncologıá Ángel H., Roffo, Buenos Aires, 1417, Argentina
Palabras clave:Connectivity; Drosophila; Locomotor rhythms; Non-circadian neurons; SLNvs; article; Drosophila; excitability; fluorescence imaging; locomotion; membrane; nonhuman; rhythm; synapse
Año:2019
Volumen:8
Número:1
DOI: http://dx.doi.org/10.1242/bio.039628
Título revista:Biology Open
Título revista abreviado:Biol. Open
ISSN:20466390
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20466390_v8_n1_p_Pirez

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Citas:

---------- APA ----------
Pırez, N., Bernabei-Cornejo, S.G., Fernandez-Acosta, M., Duhart, J.M. & Fernanda Ceriani, M. (2019) . Contribution of non-circadian neurons to the temporal organization of locomotor activity. Biology Open, 8(1).
http://dx.doi.org/10.1242/bio.039628
---------- CHICAGO ----------
Pırez, N., Bernabei-Cornejo, S.G., Fernandez-Acosta, M., Duhart, J.M., Fernanda Ceriani, M. "Contribution of non-circadian neurons to the temporal organization of locomotor activity" . Biology Open 8, no. 1 (2019).
http://dx.doi.org/10.1242/bio.039628
---------- MLA ----------
Pırez, N., Bernabei-Cornejo, S.G., Fernandez-Acosta, M., Duhart, J.M., Fernanda Ceriani, M. "Contribution of non-circadian neurons to the temporal organization of locomotor activity" . Biology Open, vol. 8, no. 1, 2019.
http://dx.doi.org/10.1242/bio.039628
---------- VANCOUVER ----------
Pırez, N., Bernabei-Cornejo, S.G., Fernandez-Acosta, M., Duhart, J.M., Fernanda Ceriani, M. Contribution of non-circadian neurons to the temporal organization of locomotor activity. Biol. Open. 2019;8(1).
http://dx.doi.org/10.1242/bio.039628