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Abstract:

Epigenetic mechanisms (i.e., histone post-translational modification and DNA methylation) play a role in regulation of gene expression. The pedunculopontine nucleus (PPN), part of the reticular activating system, manifests intrinsic gamma oscillations generated by voltage-dependent, high threshold N- and P/Q-type Ca 2+ channels. We studied whether PPN intrinsic gamma oscillations are affected by inhibition of histone deacetylation. We showed that, a) acute in vitro exposure to the histone deacetylation Class I and II inhibitor trichostatin A (TSA, 1 μM) eliminated oscillations in the gamma range, but not lower frequencies, b) pre-incubation with TSA (1 μM, 90–120 min) also decreased gamma oscillations, c) Ca 2+ currents (I Ca ) were reduced by TSA, especially on cells with P/Q-type channels, d) a HDAC Class I inhibitor MS275 (500 nM), and a Class IIb inhibitor Tubastatin A (150–500 nM), failed to affect gamma oscillations, e) MC1568, a HDAC Class IIa inhibitor (1 μM), blocked gamma oscillations, and f) the effects of both TSA and MC1568 were blunted by blockade of CaMKII with KN-93 (1 μM). These results suggest a cell type specific effect on gamma oscillations when histone deacetylation is blocked, suggesting that gamma oscillations through P/Q-type channels modulated by CaMKII may be linked to processes related to gene transcription. © 2018, The Author(s).

Registro:

Documento: Artículo
Título:Class II histone deacetylases require P/Q-type Ca 2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus
Autor:Urbano, F.J.; Bisagno, V.; Mahaffey, S.; Lee, S.-H.; Garcia-Rill, E.
Filiación:Center for Translational Neuroscience, Department Neurobiology & Dev. Sci., University of Arkansas for Medical Sciences, Little Rock, AR, United States
IFIBYNE, CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
ININFA, CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
Department Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Año:2018
Volumen:8
Número:1
DOI: http://dx.doi.org/10.1038/s41598-018-31584-2
Título revista:Scientific Reports
Título revista abreviado:Sci. Rep.
ISSN:20452322
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v8_n1_p_Urbano

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Citas:

---------- APA ----------
Urbano, F.J., Bisagno, V., Mahaffey, S., Lee, S.-H. & Garcia-Rill, E. (2018) . Class II histone deacetylases require P/Q-type Ca 2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus. Scientific Reports, 8(1).
http://dx.doi.org/10.1038/s41598-018-31584-2
---------- CHICAGO ----------
Urbano, F.J., Bisagno, V., Mahaffey, S., Lee, S.-H., Garcia-Rill, E. "Class II histone deacetylases require P/Q-type Ca 2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus" . Scientific Reports 8, no. 1 (2018).
http://dx.doi.org/10.1038/s41598-018-31584-2
---------- MLA ----------
Urbano, F.J., Bisagno, V., Mahaffey, S., Lee, S.-H., Garcia-Rill, E. "Class II histone deacetylases require P/Q-type Ca 2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus" . Scientific Reports, vol. 8, no. 1, 2018.
http://dx.doi.org/10.1038/s41598-018-31584-2
---------- VANCOUVER ----------
Urbano, F.J., Bisagno, V., Mahaffey, S., Lee, S.-H., Garcia-Rill, E. Class II histone deacetylases require P/Q-type Ca 2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus. Sci. Rep. 2018;8(1).
http://dx.doi.org/10.1038/s41598-018-31584-2