Abstract:
Threat conditioning is held as a model of anxiety disorders. However, this approach is focused on implicit responses evaluated in a single day. Here, we evaluated negative-valence, positive-valence and cognitive-systems in order to evaluate the extent to which threat conditioning models anxiety disorders. Subjects underwent threat conditioning and five-minutes (Short-term evaluation) or 48 hs (Long-term evaluation) later, both groups performed several tasks targeting cognitive-systems and valenced-systems. In the short-term evaluation, successful conditioning maintained state-anxiety and increased the aversiveness representation of the CS+ and the valuation for negative events. Reaction-times for the CS+ were faster, reflecting an attentional bias toward threat. In the long-term evaluation, participants represented the CS+ as more aversive and generalized to all stimuli. Reaction-times showed a more restricted attentional bias. Threat conditioning alters the negative-valence systems and creates a cognitive bias, which is transformed by memory consolidation, suggesting that this protocol could be a useful resource to understand the deficits associated with anxiety disorders. © 2018, The Author(s).
Registro:
Documento: |
Artículo
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Título: | Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems |
Autor: | Fernández, R.S.; Picco, S.; Messore, F.; Pedreira, M.E. |
Filiación: | Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiologia, Biologia Molecular y Celular, CONICET-Universidad de Buenos Aires, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina
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Año: | 2018
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Volumen: | 8
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Número: | 1
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DOI: |
http://dx.doi.org/10.1038/s41598-018-29603-3 |
Título revista: | Scientific Reports
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Título revista abreviado: | Sci. Rep.
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ISSN: | 20452322
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v8_n1_p_Fernandez |
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Citas:
---------- APA ----------
Fernández, R.S., Picco, S., Messore, F. & Pedreira, M.E.
(2018)
. Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems. Scientific Reports, 8(1).
http://dx.doi.org/10.1038/s41598-018-29603-3---------- CHICAGO ----------
Fernández, R.S., Picco, S., Messore, F., Pedreira, M.E.
"Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems"
. Scientific Reports 8, no. 1
(2018).
http://dx.doi.org/10.1038/s41598-018-29603-3---------- MLA ----------
Fernández, R.S., Picco, S., Messore, F., Pedreira, M.E.
"Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems"
. Scientific Reports, vol. 8, no. 1, 2018.
http://dx.doi.org/10.1038/s41598-018-29603-3---------- VANCOUVER ----------
Fernández, R.S., Picco, S., Messore, F., Pedreira, M.E. Effects of Threat Conditioning on the Negative Valanced Systems and Cognitive Systems. Sci. Rep. 2018;8(1).
http://dx.doi.org/10.1038/s41598-018-29603-3