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Abstract:

Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness. © 2017 The Author(s).

Registro:

Documento: Artículo
Título:On wakefulness fluctuations as a source of BOLD functional connectivity dynamics
Autor:Haimovici, A.; Tagliazucchi, E.; Balenzuela, P.; Laufs, H.
Filiación:Departamento de Física, Facultad de Cs. Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Av. Cantilo s/n, Pabellón 1, Buenos Aires, 1428, Argentina
Instituto de Física de Buenos Aires (IFIBA), CONICET, Ciudad Universitaria, Av Cantilo s/n, Pabellón 1, Buenos Aires, 1428, Argentina
Netherlands Institute for Neuroscience, Meibergdreef 47, Amsterdam-Zuidoost, 1105 BA, Netherlands
Department of Neurology and Brain Imaging Center, Goethe University Frankfurt Am Main, Schleusenweg 2-16, Frankfurt am Main, 60528, Germany
Department of Neurology, University Hospital Kiel, Arnold-Heller-Straße 3, Kiel, 24105, Germany
Palabras clave:oxygen; blood; cluster analysis; electroencephalography; female; human; male; narcolepsy; nerve cell network; pathophysiology; physiology; REM sleep; reproducibility; wakefulness; young adult; Cluster Analysis; Electroencephalography; Female; Humans; Male; Narcolepsy; Nerve Net; Oxygen; Reproducibility of Results; Sleep, REM; Wakefulness; Young Adult
Año:2017
Volumen:7
Número:1
DOI: http://dx.doi.org/10.1038/s41598-017-06389-4
Título revista:Scientific Reports
Título revista abreviado:Sci. Rep.
ISSN:20452322
CAS:oxygen, 7782-44-7; Oxygen
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v7_n1_p_Haimovici

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Citas:

---------- APA ----------
Haimovici, A., Tagliazucchi, E., Balenzuela, P. & Laufs, H. (2017) . On wakefulness fluctuations as a source of BOLD functional connectivity dynamics. Scientific Reports, 7(1).
http://dx.doi.org/10.1038/s41598-017-06389-4
---------- CHICAGO ----------
Haimovici, A., Tagliazucchi, E., Balenzuela, P., Laufs, H. "On wakefulness fluctuations as a source of BOLD functional connectivity dynamics" . Scientific Reports 7, no. 1 (2017).
http://dx.doi.org/10.1038/s41598-017-06389-4
---------- MLA ----------
Haimovici, A., Tagliazucchi, E., Balenzuela, P., Laufs, H. "On wakefulness fluctuations as a source of BOLD functional connectivity dynamics" . Scientific Reports, vol. 7, no. 1, 2017.
http://dx.doi.org/10.1038/s41598-017-06389-4
---------- VANCOUVER ----------
Haimovici, A., Tagliazucchi, E., Balenzuela, P., Laufs, H. On wakefulness fluctuations as a source of BOLD functional connectivity dynamics. Sci. Rep. 2017;7(1).
http://dx.doi.org/10.1038/s41598-017-06389-4