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Abstract:

Learning to avoid threats in the environment is highly adaptive. However, sometimes a dysregulation of fear memories processing may underlie fear-related disorders. Despite recent advances, a major question of how to effectively attenuate persistent fear memories in a safe manner remains unresolved. Here we show experiments employing a behavioural tool to target a specific time window after training to limit the persistence of a fear memory in rats. We observed that exposure to a novel environment 11 h after an inhibitory avoidance (IA) training that induces a long-lasting memory, attenuates the durability of IA memory but not its formation. This effect is time-restricted and not seen when the environment is familiar. In addition, novelty-induced attenuation of IA memory durability is prevented by the intrahippocampal infusion of the CaMKs inhibitor KN-93. This new behavioural approach which targets a specific time window during late memory consolidation, might represent a new tool for reducing the durability of persistent fear memories. © The Author(s) 2016.

Registro:

Documento: Artículo
Título:Novelty during a late postacquisition time window attenuates the persistence of fear memory
Autor:Katche, C.; Tomaiuolo, M.; Dorman, G.; Medina, J.H.; Viola, H.
Filiación:Instituto de Biología Celular y Neurociencias, Facultad de Medicina Dr Eduardo de Robertis (UBA-CONICET), UBA, Paraguay 2155, 3 piso, Buenos Aires, C1121ABG, Argentina
Departamento de Fisiología, Facultad de Medicina, UBA, Paraguay 2155, 7 piso, Buenos Aires, C1121ABG, Argentina
Departamento de Fisiología, Biología Molecular y Celular Dr Hector Maldonado, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
Palabras clave:animal; avoidance behavior; fear; male; memory; rat; Wistar rat; Animals; Avoidance Learning; Fear; Male; Memory; Rats; Rats, Wistar
Año:2016
Volumen:6
DOI: http://dx.doi.org/10.1038/srep35220
Título revista:Scientific Reports
Título revista abreviado:Sci. Rep.
ISSN:20452322
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20452322_v6_n_p_Katche

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Citas:

---------- APA ----------
Katche, C., Tomaiuolo, M., Dorman, G., Medina, J.H. & Viola, H. (2016) . Novelty during a late postacquisition time window attenuates the persistence of fear memory. Scientific Reports, 6.
http://dx.doi.org/10.1038/srep35220
---------- CHICAGO ----------
Katche, C., Tomaiuolo, M., Dorman, G., Medina, J.H., Viola, H. "Novelty during a late postacquisition time window attenuates the persistence of fear memory" . Scientific Reports 6 (2016).
http://dx.doi.org/10.1038/srep35220
---------- MLA ----------
Katche, C., Tomaiuolo, M., Dorman, G., Medina, J.H., Viola, H. "Novelty during a late postacquisition time window attenuates the persistence of fear memory" . Scientific Reports, vol. 6, 2016.
http://dx.doi.org/10.1038/srep35220
---------- VANCOUVER ----------
Katche, C., Tomaiuolo, M., Dorman, G., Medina, J.H., Viola, H. Novelty during a late postacquisition time window attenuates the persistence of fear memory. Sci. Rep. 2016;6.
http://dx.doi.org/10.1038/srep35220