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Gueron, G.; Anselmino, N.; Chiarella, P.; Ortiz, E.G.; Lage Vickers, S.; Paez, A.V.; Giudice, J.; Contin, M.D.; Leonardi, D.; Jaworski, F.; Manzano, V.; Strazza, A.; Montagna, D.R.; Labanca, E.; Cotignola, J.; Daccorso, N.; Woloszynska-Read, A.; Navone, N. (...) Vazquez, E. "Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article" (2018) Cell Death and Disease. 9(2)
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Abstract:

An abrupt increase in metastatic growth as a consequence of the removal of primary tumors suggests that the concomitant resistance (CR) phenomenon might occur in human cancer. CR occurs in murine tumors and ROS-damaged phenylalanine, meta-tyrosine (m-Tyr), was proposed as the serum anti-tumor factor primarily responsible for CR. Herein, we demonstrate for the first time that CR happens in different experimental human solid tumors (prostate, lung anaplastic, and nasopharyngeal carcinoma). Moreover, m-Tyr was detected in the serum of mice bearing prostate cancer (PCa) xenografts. Primary tumor growth was inhibited in animals injected with m-Tyr. Further, the CR phenomenon was reversed when secondary implants were injected into mice with phenylalanine (Phe), a protective amino acid highly present in primary tumors. PCa cells exposed to m-Tyr in vitro showed reduced cell viability, downregulated NFκB/STAT3/Notch axis, and induced autophagy; effects reversed by Phe. Strikingly, m-Tyr administration also impaired both, spontaneous metastasis derived from murine mammary carcinomas (4T1, C7HI, and LMM3) and PCa experimental metastases. Altogether, our findings propose m-Tyr delivery as a novel approach to boost the therapeutic efficacy of the current treatment for metastasis preventing the escape from tumor dormancy. © 2018 The Author(s).

Registro:

Documento: Artículo
Título:Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article
Autor:Gueron, G.; Anselmino, N.; Chiarella, P.; Ortiz, E.G.; Lage Vickers, S.; Paez, A.V.; Giudice, J.; Contin, M.D.; Leonardi, D.; Jaworski, F.; Manzano, V.; Strazza, A.; Montagna, D.R.; Labanca, E.; Cotignola, J.; Daccorso, N.; Woloszynska-Read, A.; Navone, N.; Meiss, R.P.; Ruggiero, R.; Vazquez, E.
Filiación:Departamento de Química Biológica, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Laboratorio de Inflamación y Cáncer, Buenos Aires, Argentina
CONICET- Universidad de Buenos Aires, Instituto de Química Biológica, Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina
Laboratory of Experimental Oncology, IMEX-CONICET (National Council of Scientific and Technical Research), National Academy of Medicine, Buenos Aires, Argentina
Department of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
Department of Organic Chemistry, CIHIDECAR-CONICET, FCEN, University of Buenos Aires, Buenos Aires, Argentina
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, United States
Department of Genitourinary Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States
Laboratory of Pathology, Institute of Oncological Studies (IEO), National Academy of Medicine, Buenos Aires, Argentina
Palabras clave:immunoglobulin enhancer binding protein; meta tyrosine; Notch receptor; phenylalanine; STAT3 protein; amino acid blood level; animal cell; animal experiment; animal model; animal tissue; antiproliferative activity; Article; autophagy; cancer growth; cancer inhibition; cancer resistance; cell viability; controlled study; down regulation; drug mechanism; experimental metastasis; human; human cell; in vitro study; lung cancer; male; mouse; nasopharynx carcinoma; nonhuman; primary tumor; priority journal; prostate cancer; solid malignant neoplasm
Año:2018
Volumen:9
Número:2
DOI: http://dx.doi.org/10.1038/s41419-017-0147-8
Título revista:Cell Death and Disease
Título revista abreviado:Cell Death Dis.
ISSN:20414889
CAS:meta tyrosine, 2180-37-2, 775-06-4; phenylalanine, 3617-44-5, 63-91-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20414889_v9_n2_p_Gueron

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Citas:

---------- APA ----------
Gueron, G., Anselmino, N., Chiarella, P., Ortiz, E.G., Lage Vickers, S., Paez, A.V., Giudice, J.,..., Vazquez, E. (2018) . Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article. Cell Death and Disease, 9(2).
http://dx.doi.org/10.1038/s41419-017-0147-8
---------- CHICAGO ----------
Gueron, G., Anselmino, N., Chiarella, P., Ortiz, E.G., Lage Vickers, S., Paez, A.V., et al. "Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article" . Cell Death and Disease 9, no. 2 (2018).
http://dx.doi.org/10.1038/s41419-017-0147-8
---------- MLA ----------
Gueron, G., Anselmino, N., Chiarella, P., Ortiz, E.G., Lage Vickers, S., Paez, A.V., et al. "Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article" . Cell Death and Disease, vol. 9, no. 2, 2018.
http://dx.doi.org/10.1038/s41419-017-0147-8
---------- VANCOUVER ----------
Gueron, G., Anselmino, N., Chiarella, P., Ortiz, E.G., Lage Vickers, S., Paez, A.V., et al. Game-changing restraint of Ros-damaged phenylalanine, upon tumor metastasis article. Cell Death Dis. 2018;9(2).
http://dx.doi.org/10.1038/s41419-017-0147-8