Artículo
Peinetti, A.S.; Ceretti, H.; Mizrahi, M.; González, G.A.; Ramírez, S.A.; Requejo, F.G.; Montserrat, J.M.; Battaglini, F. "Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors" (2015) Nanoscale. 7(17):7763-7769
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Abstract:
A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale. © The Royal Society of Chemistry 2015.
Registro:
| Documento: | Artículo |
| Título: | Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors |
| Autor: | Peinetti, A.S.; Ceretti, H.; Mizrahi, M.; González, G.A.; Ramírez, S.A.; Requejo, F.G.; Montserrat, J.M.; Battaglini, F. |
| Filiación: | Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, C1428EHA, Argentina Universidad Nacional de Gral. Sarmiento, J. M. Gutierrez 1150, Los Polvorines, Prov. de Bs. As. B1613GSX, Argentina INGEBI (CONICET), Vuelta de Obligado 2490, Buenos Aires, 1428, Argentina Instituto de Investigaciones Físicoquímicas Teóricas y Aplicadas - INIFTA, La Plata, 1900, Argentina |
| Palabras clave: | Alumina; Electric conductance; Electrochemical impedance spectroscopy; Electron transport properties; Fiber optic sensors; Gold; Metal nanoparticles; Molecules; Nanoparticles; Adenosine monophosphate; Conducting surfaces; Conformational change; Controlled architecture; Fast electron transfer; Label-free detection; Small-molecule bindings; Uncapped Nanoparticles; Synthesis (chemical); adenosine phosphate; aluminum oxide; aptamer; gold; metal nanoparticle; chemistry; impedance; nanotechnology; porosity; procedures; Adenosine Monophosphate; Aluminum Oxide; Aptamers, Nucleotide; Electric Impedance; Gold; Metal Nanoparticles; Nanotechnology; Porosity |
| Año: | 2015 |
| Volumen: | 7 |
| Número: | 17 |
| Página de inicio: | 7763 |
| Página de fin: | 7769 |
| DOI: | http://dx.doi.org/10.1039/c5nr01429h |
| Título revista: | Nanoscale |
| Título revista abreviado: | Nanoscale |
| ISSN: | 20403364 |
| CAS: | adenosine phosphate, 61-19-8, 8063-98-7; aluminum oxide, 1302-74-5, 1318-23-6, 1344-28-1, 14762-49-3; gold, 7440-57-5; Adenosine Monophosphate; Aluminum Oxide; Aptamers, Nucleotide; Gold |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20403364_v7_n17_p7763_Peinetti |
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Citas:
---------- APA ----------
Peinetti, A.S., Ceretti, H., Mizrahi, M., González, G.A., Ramírez, S.A., Requejo, F.G., Montserrat, J.M.,..., Battaglini, F. (2015) . Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors. Nanoscale, 7(17), 7763-7769.http://dx.doi.org/10.1039/c5nr01429h
---------- CHICAGO ----------
Peinetti, A.S., Ceretti, H., Mizrahi, M., González, G.A., Ramírez, S.A., Requejo, F.G., et al. "Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors" . Nanoscale 7, no. 17 (2015) : 7763-7769.http://dx.doi.org/10.1039/c5nr01429h
---------- MLA ----------
Peinetti, A.S., Ceretti, H., Mizrahi, M., González, G.A., Ramírez, S.A., Requejo, F.G., et al. "Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors" . Nanoscale, vol. 7, no. 17, 2015, pp. 7763-7769.http://dx.doi.org/10.1039/c5nr01429h
---------- VANCOUVER ----------
Peinetti, A.S., Ceretti, H., Mizrahi, M., González, G.A., Ramírez, S.A., Requejo, F.G., et al. Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors. Nanoscale. 2015;7(17):7763-7769.http://dx.doi.org/10.1039/c5nr01429h
