Abstract:
The possibility of combining more than one stimulus-responsive property into a single material holds interesting potential for the creation of adaptive devices to be used in diverse fields such as drug delivery, nanomedicine and tissue engineering. This paper describes a novel material based on thermo-responsive PNIPAm nanopillars with amplified surface properties through the incorporation of Fe3O4 nanoparticles. The incorporation of magnetic nanoparticles into the nanopillars, prepared via surface-initiated atom-transfer radical polymerization in anodized aluminum oxide templates, sharply increased their stiffness and hydrophobicity when increasing the temperature above the volume phase transition temperature. Furthermore, their magnetic response turned out to be proportional to the amount of the incorporated nanoparticles. The possibility of sharply increasing the stiffness with a temperature variation close to the human body temperature paves the way to the application of these substrates as "smart" scaffolds for cell culture. Additionally, the presence of superparamagnetic nanoparticles in the nanopillars offers the possibility of using these nanostructured systems for magnetic hyperthermia. © 2018 The Royal Society of Chemistry.
Registro:
Documento: |
Artículo
|
Título: | Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles |
Autor: | Giussi, J.M.; Von Bilderling, C.; Alarcón, E.; Pietrasanta, L.I.; Hernandez, R.; Del Real, R.P.; Vázquez, M.; Mijangos, C.; Cortez, M.L.; Azzaroni, O. |
Filiación: | Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química-Facultad de Ciencias Exactas, Universidad Nacional de la Plata, CONICET, La Plata, 1900, Argentina Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EHA, Argentina Instituto de Física de Buenos Aires (IFIBA), CONICET, Universidad de Buenos Aires, Buenos Aires, C1428EHA, Argentina Centro de Microscopías Avanzadas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428EHA, Argentina Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, Madrid, 28006, Spain Instituto de Ciencia de Materiales de Madrid, CSIC, Sor Juana Inés de la Cruz 3, Madrid, 28049, Spain
|
Palabras clave: | Acrylics; Atom transfer radical polymerization; Cell culture; Free radical reactions; Iron compounds; Magnetism; Medical nanotechnology; Nanomagnetics; Nanoparticles; Nanostructures; Scaffolds (biology); Stiffness; Temperature; Tissue engineering; Anodized aluminum oxide; Human body temperature; Magnetic nano-particles; Nanostructured systems; Superparamagnetic nanoparticles; Surface initiated-atom transfer radical polymerization; Temperature variation; Volume phase transition; Drug delivery |
Año: | 2018
|
Volumen: | 10
|
Número: | 3
|
Página de inicio: | 1189
|
Página de fin: | 1195
|
DOI: |
http://dx.doi.org/10.1039/c7nr06209e |
Título revista: | Nanoscale
|
Título revista abreviado: | Nanoscale
|
ISSN: | 20403364
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20403364_v10_n3_p1189_Giussi |
Referencias:
- Assender, H., (2002) Science, 297, pp. 973-976
- Yang, Y., Kulangara, K., Lam, R.T.S., Dharmawan, R., Leong, K.W., (2012) ACS Nano, 6, pp. 8591-8598
- Lutolf, M.P., (2009) Nat. Mater., 8, pp. 451-453
- Vashist, A., Vashist, A., Gupta, Y.K., Ahmad, S., (2014) J. Mater. Chem. B, 2, pp. 147-166
- Kaholek, M., Lee, W.K., Feng, J., Lamattina, B., Dyer, D.J., Zauscher, S., (2006) Chem. Mater., 18, pp. 3660-3664
- Senff, H., Richtering, W., (1999) J. Chem. Phys., 111, pp. 1705-1711
- Peng, J., Qi, T., Liao, J., Fan, M., Luo, F., Li, H., Qian, Z., (2012) Nanoscale, 4, p. 2694
- Yang, J.A., Yeom, J., Hwang, B.W., Hoffman, A.S., Hahn, S.K., (2014) Prog. Polym. Sci., pp. 1-14
- Ionov, L., (2014) Mater. Today, 17, pp. 494-503
- Wang, D., Cheng, D., Guan, Y., Zhang, Y., (2011) Biomacromolecules, 12, pp. 578-584
- Shen, J., Ye, T., Chang, A., Wu, W., Zhou, S., (2012) Soft Matter, pp. 12034-12042
- Molina, M., Asadian-Birjand, M., Balach, J., Bergueiro, J., Miceli, E., Calderón, M., (2015) Chem. Soc. Rev., 44, pp. 6161-6186
- Becerra, N., Andrade, H., López, B., Restrepo, L.M., Raiteri, R., (2015) J. Biomed. Mater. Res., Part A, 103, pp. 145-153
- Ashraf, S., Park, H.K., Park, H., Lee, S.H., (2016) Macromol. Res., 24, pp. 297-304
- Mijangos, C., Hernandez, R., Martin, J., (2015) Prog. Polym. Sci., 54-55, pp. 148-182
- Giussi, J.M., Blaszczyk-Lezak, I., Allegretti, P.E., Cortizo, M.S., Mijangos, C., (2013) Polymer, 54, pp. 5050-5057
- Martín, J., Mijangos, C., (2009) Langmuir, 25, pp. 1181-1187
- Wang, Y., Lee, J.Y., Zeng, H.C., Crescent, K.R., (2005) Chem. Mater., 17, pp. 3899-3903
- Choi, M.K., Yoon, H., Lee, K., Shin, K., (2011) Langmuir, 27, pp. 2132-2137
- Cui, Y., Tao, C., Zheng, S., He, Q., Ai, S., Li, J., (2005) Macromol. Rapid Commun., 26, pp. 1552-1556
- Wang, H.J., Zhou, W.H., Yin, X.F., Zhuang, Z.X., Yang, H.H., Wang, X.R., (2006) J. Am. Chem. Soc., 128, pp. 15954-15955
- Giussi, J.M., Blaszczyk-Lezak, I., Cortizo, M.S., Mijangos, C., (2013) Polymer, 54, pp. 6886-6893
- Woo, B., Cho, K., Choi, I.S., (2008) Adv. Funct. Mater., pp. 1089-1096
- Sanz, B., Von Bilderling, C., Tuninetti, J.S., Pietrasanta, L., Mijangos, C., Longo, G.S., Azzaroni, O., Giussi, J.M., (2017) Soft Matter, 13, pp. 2453-2464
- Jańczewski, D., Tomczak, N., Han, M.Y., Vancso, G.J., (2009) Macromolecules, 42, pp. 1801-1804
- Gui, R., An, X., Gong, J., Chen, T., (2012) Mater. Lett., 88, pp. 122-125
- Xu, H., Xu, J., Zhu, Z., Liu, H., Liu, S., (2006) Macromolecules, 39, pp. 8451-8455
- Kawano, T., Niidome, Y., Mori, T., Katayama, Y., Niidome, T., (2009) Bioconjugate Chem., 20, pp. 209-212
- Jin, H., Liu, X., Gui, R., Wang, Z., (2015) Colloids Surf., B, 128, pp. 498-505
- Luo, B., Song, X.-J., Zhang, F., Xia, A., Yang, W.-L., Hu, J.-H., Wang, C.-C., (2010) Langmuir, 26, pp. 1674-1679
- Sun, J., Gui, R., Jin, H., Li, N., Wang, X., (2016) RSC Adv., 6, pp. 8722-8728
- Tang, H., Shen, S., Guo, J., Chang, B., Jiang, X., Yang, W., (2012) J. Mater. Chem., 22, pp. 16095-16103
- Borlido, L., Moura, L., Azevedo, A.M., Roque, A.C.A., Aires-Barros, M.R., Farinha, J.P.S., (2013) Biotechnol. J., 8, pp. 709-717
- Kim, J., Chung, S.E., Choi, S., Lee, H., Kim, J., Kwon, S., (2011) Nat. Mater., 10, pp. 747-752
- Drotlef, D.M., Blümler, P., Papadopoulos, P., Del Campo, A., (2014) ACS Appl. Mater. Interfaces, 6, pp. 8702-8707
- Masuda, H., Yotsuya, M., Ishida, M., (1998) Jpn. J. Appl. Phys., Part 2, 37, pp. L1090-L1092
- Hernández-Vélez, M., (2006) Thin Solid Films, 495, pp. 51-63
- Hutter, J.L., Bechhoefer, J., (1993) Rev. Sci. Instrum., 64, pp. 1868-1873
- Lin, D.C., Dimitriadis, E.K., Horkay, F., (2007) J. Biomech. Eng., 129, pp. 904-912
- Oliver, W.C., Pharr, G.M., (1992) J. Mater. Res., 7, pp. 1564-1580
- Plodinec, M., Loparic, M., Monnier, C.A., Obermann, E.C., Zanetti-Dallenbach, R., Oertle, P., Hyotyla, J.T., Schoenenberger, C.-A., (2012) Nat. Nanotechnol., 7, pp. 757-765
- Castaneda, L., Valle, J., Yang, N., Pluskat, S., Slowinska, K., Castaneda, L., Valle, J., Slowinska, K., (2008) Biomacromolecules, 9, pp. 3383-3388
- Cheng, X., Canavan, H.E., Stein, M.J., Hull, J.R., Kweskin, S.J., Wagner, M.S., Somorjai, G.A., Ratner, B.D., (2005) Langmuir, 21, pp. 7833-7841
- Schmidt, S., Zeiser, M., Hellweg, T., Duschl, C., Fery, A., Möhwald, H., (2010) Adv. Funct. Mater., 20, pp. 3235-3243
- Burmistrova, A., Richter, M., Eisele, M., Üzüm, C., Von Klitzing, R., (2011) Polymers, 3, pp. 1575-1590
- Koppolu, B., Bhavsar, Z., Wadajkar, A.S., Nattama, S., Rahimi, M., Nwariaku, F., Nguyen, K.T., (2012) J. Biomed. Nanotechnol., 8, pp. 983-990
Citas:
---------- APA ----------
Giussi, J.M., Von Bilderling, C., Alarcón, E., Pietrasanta, L.I., Hernandez, R., Del Real, R.P., Vázquez, M.,..., Azzaroni, O.
(2018)
. Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles. Nanoscale, 10(3), 1189-1195.
http://dx.doi.org/10.1039/c7nr06209e---------- CHICAGO ----------
Giussi, J.M., Von Bilderling, C., Alarcón, E., Pietrasanta, L.I., Hernandez, R., Del Real, R.P., et al.
"Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles"
. Nanoscale 10, no. 3
(2018) : 1189-1195.
http://dx.doi.org/10.1039/c7nr06209e---------- MLA ----------
Giussi, J.M., Von Bilderling, C., Alarcón, E., Pietrasanta, L.I., Hernandez, R., Del Real, R.P., et al.
"Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles"
. Nanoscale, vol. 10, no. 3, 2018, pp. 1189-1195.
http://dx.doi.org/10.1039/c7nr06209e---------- VANCOUVER ----------
Giussi, J.M., Von Bilderling, C., Alarcón, E., Pietrasanta, L.I., Hernandez, R., Del Real, R.P., et al. Thermo-responsive PNIPAm nanopillars displaying amplified responsiveness through the incorporation of nanoparticles. Nanoscale. 2018;10(3):1189-1195.
http://dx.doi.org/10.1039/c7nr06209e