Abstract:
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal’s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration. © 2015 Brazilian Association of Sleep.
Registro:
Documento: |
Artículo
|
Título: | Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse |
Autor: | Urbano, F.J.; Bisagno, V.; González, B.; Rivero-Echeto, M.C.; MuñIz, J.A.; Luster, B.; D’Onofrio, S.; Mahaffey, S.; Garcia-Rill, E. |
Filiación: | Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States Ifibyne-conicet, Ininfa-conicet, University of Buenos Aires, Argentina
|
Palabras clave: | Amphetamine; Cocaine; Dopamine; Nicotine; P/Q-type calciumchannels T-type calciumchannels; calcium channel; cocaine; nicotine; psychostimulant agent; behavior; human; locomotion; membrane potential; pedunculopontine tegmental nucleus; physiology; Review; sleep arousal disorder; sleep deprivation |
Año: | 2015
|
Volumen: | 8
|
Número: | 3
|
Página de inicio: | 162
|
Página de fin: | 168
|
DOI: |
http://dx.doi.org/10.1016/j.slsci.2015.09.004 |
Título revista: | Sleep Science
|
Título revista abreviado: | Sleep Sci.
|
ISSN: | 19840659
|
CAS: | cocaine, 50-36-2, 53-21-4, 5937-29-1; nicotine, 54-11-5
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n3_p162_Urbano |
Referencias:
- Garcia-Rill, E., The RAS and Drug Abuse in Reticular Activating System in Waking and the Reticular Activating System Health and Disease, pp. 277-290. , Academic Press, Elsevier
- Hallanger, A.E., Levey, A.I., Lee, H.J., Rye, D.B., Wainer, B.H., The origins of cholinergic and other subcortical afferents to the thalamus in the rat (1987) J. Comp. Neurol, 262, pp. 105-124
- Steriade, M., Pare, D., Parent, A., Smith, Y., Projections of cholinergic and noncholinergic neurons of the brainstem core to relay and associational thalamic nuclei in the cat and macaque monkey (1988) Neuroscience, 25, pp. 47-67
- Steriade, M., McCarley, R.W., (2005) Brain Control of Wakefulness and Sleep, , New York: Springer
- Steriade, M., Datta, S., Pare, D., Oakson, G., Curro Dossi, R.C., Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems (1990) J. Neurosci, 10, pp. 2541-2559
- Steriade, M., Jones, E.G., McCormick, D.A., (1997) Thalamus, Volume I: Organization and Function, , Amsterdam: Elsevier
- Deschenes, M., Madariaga-Domich, A., Steriade, M., Dendroden- dritic synapses in cat reticularis thalami nucleus, a structural basis for thalamic spindle synchronization (1985) Brain Res, 334, pp. 169-171
- Landisman, C.E., Long, M.A., Beierlein, M., Electrical synapses in the thalamic reticular nucleus (2002) J. Neurosci, 22, pp. 1002-1009
- Ben-Ari, Y., Dingledine, R., Kanazawa, I., Kelly, J.S., Inhibitory effects of acetylcholine on neurones in the feline nucleus reticularis thalami (1976) J. Physiol. (Lond.), 261, pp. 647-671
- Bista, P., Meuth, S.G., Kanyshkova, T., Cerina, M., Pawlowsk, M., Ehling, P., Landgraf, P., Budde, T., Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons (2012) Pflugers Arch, 463, pp. 89-102
- Llinás, R.R., Ribary, U., Jeanmonod, D., Kronberg, E., Mitra PP Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalo- graphy (1999) Proc. Natl. Acad. Sci. USA, 96, pp. 15222-15227
- Llinás, R.R., Urbano, F.J., Leznik, E., Ramirez, R.R., Van Marle, H.J., Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect (2005) Trends Neurosci, 28, pp. 325-333
- Llinas, R.R., Choi, S., Urbano, F.J., Hee-Sup S. Y-Band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 17819-17824
- Di Chiara, G., Imperato, A., Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl (1988) Acad. Sci. USA, 85, pp. 5274-5278
- Maskos, U., The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: Relevance to the drugs of abuse and pathology (2008) Br. J. Pharmacol, 1, pp. 438-445
- Floresco, S.B., West, A.R., Ash, B., Moore, H., Grace AA. Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission (2003) Nat. Neu- Rosci, 6, pp. 968-973
- Good, C.H., Lupica, C.R., Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulation in vitro (2009) J. Physiol. (Lond.), 587, pp. 1233-1247
- Lammel, S., Lim, B.K., Ran, C., Huang, K.W., Betley, M.J., Tye, K.M., Deisseroth, K., Malenka, R.C., Input-specific control of reward and aversion in the ventral tegmental area (2012) Nature, 491, pp. 212-217
- Circuits, K.G., Drugs, and drug addiction. Adv (1998) Pharmacol, 42, pp. 978-982
- White, F.J., Kalivas, P.W., Neuroadaptations involved in amphetamine and cocaine addiction (1998) Drug Alcohol Depend, 51, pp. 141-153
- Wise, R.A., Drug-activation of brain reward pathways (1998) Drug Alcohol Depend, 51, pp. 13-22
- Luster, B., D’Onofrio, S., Urbano, F., Garcia-Rill, E., High-threshold Ca2+ channels behind gamma band activity in the pedun- culopontine nucleus (PPN) (2015) Physiol. Rep, 3
- Kezunovic, N., Hyde, J., Goitia, B., Bisagno, V., Urbano, F.J., Garcia- Rill, E., Muscarinic modulation of high frequency oscillations in pedunculopontine neurons (2013) Front. Neurol, 4 (176), pp. 1-13
- Hillman, D., Chen, S., Aung, T.T., Cherksey, B., Sugimori, M., Llinas, R.R., Localization of P-type calcium channels in the central nervous system (1991) Proc. Natl. Acad. Sci. USA, 88, pp. 7076-7080
- Uchitel, O.D., Protti, D.A., Sanchez, V., Cherkesey, B.D., Sugimori, M., Llinas, R.R., -type voltage dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 3330-3333
- Kezunovic, N., Urbano, F.J., Simon, C., Hyde, J., Smith, K., Garcia-Rill, E., Mechanism behind gamma band activity in pedunculo- pontine nucleus (PPN) (2011) Eur. J. Neurosci, 34, pp. 404-415
- Garcia-Rill, E., Kezunovic, N., Hyde, J., Beck, P., Urbano, F.J., . Coherence and frequency in the reticular activating system (RAS) (2013) Sleep Med. Rev, 17, pp. 227-238
- Urbano, F.J., Kezunovic, N., Hyde, J., Simon, C., Beck, P., Garcia-Rill, E., Gamma band activity in the reticular activating system (RAS) (2012) Front. Neurol. Sleep Chronobiol, 3 (6), pp. 1-16
- Pedroarena, C., Llinas, R.R., Dendritic calcium conductances generate high-frequency oscillation in thalamocortical neurons (1997) Proc. Natl. Acad. Sci. USA, 94, pp. 724-728
- Seiden, L.S., Sabol, K.E., Ricaurte, G.A., Amphetamine: Effects on catecholamine systems and behavior (1993) Annu. Rev. Pharmacol. Toxicol, 32, pp. 639-677
- Sulzer, D., Chen, T.K., Lau, Y.Y., Kristensen, H., Rayport, S., Ewing A. Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport (1995) J. Neu- Rosci, 15, pp. 4102-4108
- Mlewski, E.C., Krapacher, F.A., Ferreras, S., Paglini G. Transient enhanced expression of Cdk5 activator p25 after acute and chronic d-amphetamine administration (2008) Ann. N. Y. Acad. Sci, 1139, pp. 89-102
- Singer, B.F., Neugebauer, N.M., Forneris, J., Rodvelt, K.R., Li, D., Bubula, N., Vezina, P., Locomotor conditioning byamphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens (2014) Neuropharmacology, 85, pp. 243-252
- Tomizawa, K., Ohta, J., Matsushita, M., Moriwaki, A., Li, S., Takei, K., Matsui, H., Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity (2002) J. Neurosci, 22, pp. 2590-2597
- Karila, L., Weinstein, A., Aubin, H.J., Benyamina, A., Reynaud, M., Batki, S.L., Pharmacological approaches to methamphetamine dependence: A focused review (2010) Br. J. Clin. Pharmacol, 69, pp. 578-592
- González, B., Rivero-Echeto, C., Muniz, J.A., Cadet, J.L., Garcia-Rill, E., Urbano, F.J., Bisagno, V., Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial pre- frontal cortex (2015) Addict. Biol, , in press
- Pierre, P.J., Vezina, P., Predisposition to self-administer amphetamine: The contribution of response to novelty and prior exposure to the drug (1997) Psychopharmacology, 129, pp. 277-284
- Saito, L.P., Fukushiro, D.F., Hollais, A.W., Mari-Kawamoto, E., Costa, J.M., Berro, L.F., Aramini, T.C., Frussa-Filho, R., Acute total sleep deprivation potentiates amphetamine-induced locomotor-stimulant effects and behavioral sensitization in mice (2014) Pharmacol. Biochem. Behav, 117, pp. 7-16
- Alderson, H.L., Faulconbridge, L.F., Gregory, L.P., Latimer, M.P., Winn, P., Behavioural sensitisation to repeated d-amphetamine: Effects of excitotoxic lesions of the pedunculopontine tegmental nucleus (2003) Neuroscience, 118 (2), pp. 311-315
- Lee, R.S., Steffensen, S.C., Henriksen, S.J., Discharge profiles of ventral tegmental area GABA neurons during movement, anesthesia, and the sleep-wake cycle (2001) J. Neurosci, 21, pp. 1757-1766
- Bechara, A., Van Der Kooy, D., The tegmental pedunculopontine nucleus: A brainstem output of the limbic system critical for the conditioned place preferences produced by morphine and amphetamine (1989) J. Neurosci, 9, pp. 3400-3409
- Shannon, H.E., Peters, S.C., A comparison of the effects of cholinergic and dopaminergic agents on scopolamine- induced hyperactivity in mice (1990) J. Pharmacol. Exp. Ther, 255, pp. 549-553
- Hagan, J.J., Tonnaer, J., Rijk, H., Broekkamp, C., Van Delft, A.M.L., Facilitation of amphetamine-induced rotation by muscarinic antagonists is correlated with M2 receptor affinity (1987) Brain Res, 410, pp. 69-73
- Asanuma, C., Distribution of neuromodulatory inputs in the reticular and dorsal thalami nuclei (1997) Experimental and Clinical Aspects, 2, pp. 93-154. , Steriade M, Jones EG, McCormick DA, Thalamus, Amsterdam: Elsevier
- Wilson, M.C., Bedford, J.A., Buelke, J., Kibbe, A.H., Acute pharmacological activity of intravenous cocaine in the rhesus monkey Psychopharmacol (1976) Commun, 2, pp. 251-261
- Wise, R.A., Bozarth, M.A., A psychomotor stimulant theory of addiction (1987) Psychol. Rev, 94, pp. 469-492
- Ross, S.B., Renyi, A.L., Inhibition of the uptake of tritiated 5- hydroxytryptamine in brain tissue (1969) Eur. J. Pharmacol, 7, pp. 270-277
- Grimm, J.W., See, R.E., Cocaine self-administration in ovariec- tomized rats is predicted by response to novelty, attenuated by 17-b estradiol, and associated with abnormal vaginal cytology (1997) Physiol. Behav, 61, pp. 755-761
- Schmidt, H.D., Famous, K.R., Pierce, R.C., The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT (2009) Eur. J. Neurosci, 30, pp. 1358-1369
- Steidl, S., Wang, H., Wise, R.A., Lesions of cholinergic peduncu- lopontine tegmental nucleus neurons fail to affect cocaine or heroin self-administration or conditioned place preference in rats (2014) Plos One, 9
- Goitia, B., Raineri, M., Gonzalez, L.E., Rozas, J.L., Garcia-Rill, E., Bisagno, V., Urbano FJ. Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei (2013) J. Neurochem, 124, pp. 602-612
- Urbano, F.J., Bisagno, V., Wikinski, S.I., Uchitel, O.D., Llin^s RR. Cocaine acute "binge" administration results in altered thalamocortical interactions in mice. Biol (2009) Psychiatry, 66 (8), pp. 769-776
- Bisagno, V., Raineri, M., Peskin, V., Wikinski, S.I., Uchitel, O.D., Llinás, R.R., Urbano, F.J., Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice (2010) Psychopharmacology (Berl.), 212, pp. 205-214
- Berro, L.F., Santos, R., Hollais, A.W., Wuo-Silva, R., Fukushiro, D.F., Mari-Kawamoto, E., Costa, J.M., Frussa-Filho, R., Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice. Neurosci (2014) Lett, 579, pp. 130-133
- Raineri, M., Peskin, V., Goitia, B., Taravini, I.R., Giorgeri, S., Urbano, F.J., Bisagno, V., Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice (2011) Synapse, 65 (10), pp. 1087-1098
- Raineri, M., Gonzalez, B., Goitia, B., Garcia-Rill, E., Krasnova, I.N., Cadet, J.L., Urbano, F.J., Bisagno, V., Modafinil abrogates methamphetamine-induced neuroinflammation and apop- totic effects in the mouse striatum (2012) Plos One, 7 (10)
- Raineri, M., Gonzalez, B., Rivero-Echeto, C., Muniz, J.A., Gutierrez, M.L., Ghanem, C.I., Cadet, J.L., Bisagno, V., Differential effects of environment-induced changes in body temperature on modafinil’s actions against methamphetamine-induced striatal toxicity in mice (2014) Neu- Rotox. Res, 27 (1), pp. 71-83
- Garcia-Rill, E., Heister, D.S., Ye, M., Charlesworth, A., Hayar, A., Electrical coupling: Novel mechanism for sleep-wake control (2007) Sleep, 30, pp. 1405-1414
- Urbano, F.J., Leznik, E., Llinas, R.R., Modafinil enhances thalamocortical activity by increasing neuronal electrotonic coupling (2007) Proc. Natl. Acad. Sci. USA, 104, pp. 12554-12559
- Gonzalez, B., Raineri, M., Cadet, J.L., Garcia-Rill, E., Urbano, F.J., Bisagno, V., Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice (2014) Neuropharmacology, 87, pp. 188-197
- Edgar, C.J., Pace-Schott, E.F., Wesnes, K.A., Approaches to measuring the effects of wake-promoting drugs: A focus on cognitive function. Hum (2009) Psychopharmacol, 24 (5), pp. 371-389
- Jiang, X., Lautermilch, N.J., Watari, H., Westenbroek, R.E., Scheuer, T., Catterall, W.A., Modulation of Cav2.1 channels by Ca+/ calmodulin-dependent kinase II bound to the C-terminal domain (2008) Proc. Nat. Acad. Sci. USA, 105, pp. 341-346
- Good, C.H., Bay, K.D., Buchanan, R., Skinner, R.D., Garcia-Rill, E., Muscarinic and nicotinic responses in the developing ped- unculopontine nucleus (PPN) (2007) Brain Res, 1129, pp. 147-155
- Benowitz, N.L., Pharmacology of nicotine: Addiction and therapeutics (1996) Ann. Rev. Pharmacol. Toxicol, 36, pp. 597-613
- Simosky, J.K., Stevens, K.E., Freedman, R., Nicotinic agonists and psychosis. Curr. Drug Targets— CNS Neurol (2002) Disord, 1, pp. 177-190
- Luck, W., Nau, H., Hansen, R., Steldinger, R., Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers. Dev. Pharmacol (1985) Ther, 8, pp. 384-395
- Eskanazi, B., Prehn, A.W., Cristianson, R.E., Passive and active maternal smoking as measured by serum cotinine: The effect on birthweight (1995) Am. J. Public Health, 85, pp. 395-398
- Kline, J., Stein, Z.A., Susser, M., Warburton, D., Smoking: A risk factor for spontaneous abortion. New Engl (1997) J. Med, 297, pp. 793-796
- Bulterys, M., High incidence of sudden infant death syndrome among northern Indians and Alaska natives compared with southwestern Indians: Possible role of smoking (1990) J. Com. Health, 15, pp. 185-194
- Weissman, M.M., Warner, V., Wickramaratne, P.J., Kandel, D.B., Maternal smoking during pregnancy and psychopathology in offspring followed to adulthood (1999) J. Am. Acad. Child Adolesc. Psychiatry, 38, pp. 892-899
- Fried, P.A., O’Connell, C.M., Watkinson, B., 60 and 72-month follow-up of children prenatally exposed to marijuana, cigarettes and alcohol: Cognitive and language assessments (1992) J. Dev. Behav. Pediatr, 13, pp. 383-391
- Milberger, S., Biederman, J., Farraone, S.V., Chen, L., Jones, J., ADHD is associated with early initiation of cigarette smoking in children and adolescents (1997) J. Am. Acad. Child Adolesc. Psychiatry, 36, pp. 37-44
- Wasserman, G.A., Liu, X., Pine, D.S., Graziano, J.H., Contribution of maternal smoking during pregnancy and lead exposure to early child behavior problems (2001) Neurotoxicol. Teratol, 23 (1), pp. 13-21
- Fergusson, D.M., Woodward, L.J., Horwood, L.J., Maternal smoking during pregnancy and psychiatric adjustment in late adolescence (1998) Arch. Gen. Psychiat, 55, pp. 721-727
- Wakschlag, L.S., Lahey, B.B., Loeber, R., Green, S.M., Gordon, R.A., Leventhal, B.L., Maternal smoking during pregnancy and the risk of conduct disorders in boys (1997) Arch. Gen. Psychiatry, 54, pp. 670-676
- Rasanen, P., Hakko, H., Isohanni, M., Hodgins, S., Jarvelin, M.R., Tiihonen, J., Maternal smoking during pregnancy and risk of criminal behavior among adult male offspring in the Northern Finland 1966 Birth Cohort (1966) Am. J. Psychiatry, 156, pp. 857-862
- Levin, E.D., Briggs, S.J., Christopher, N.C., Rose, J.E., Prenatal nicotine exposure and cognitive performance in rats (1993) Neurotoxicol. Teratol, 15, pp. 251-260
- Sorenson, C.A., Raskin, L.A., Suh, Y., The effects of prenatal nicotine on radial-arm maze performance in rats (1991) Pharma-Icol. Biochem. Behav, 40, pp. 991-993
- Martin, J.C., Becker, R.F.T., The effects of maternal nicotine absorption or hypoxic episodes upon appetitive behavior of rat offspring (1971) Dev. Psychobiol, 4, pp. 133-147
- Garcia-Rill, E., Buchanan, R., McKeon, K., Skinner, R.D., Wallace, T., Smoking during pregnancy: Postnatal effects on arousal andi attentional brain systems (2007) Neurotox, 28, pp. 915-923
- Cadet, J.L., Bisagno, V., Milroy, C.M., Neuropathology of substance r use disorders (2014) Acta Neuropathol, 127 (1), pp. 91-107
- Hasler, B.P., Soehner, A.M., Clark, D.B., Circadian rhythms and risk for substance use disorders in adolescence (2014) Curr. Opin. Psychiatry, 27 (6), pp. 460-466
- Brower, K.J., Perron, B.E., Sleep disturbances as a universal risk factor for relapse in addictions to psychoactive substances (2010) Med. Hypotheses, 74, pp. 928-933
Citas:
---------- APA ----------
Urbano, F.J., Bisagno, V., González, B., Rivero-Echeto, M.C., MuñIz, J.A., Luster, B., D’Onofrio, S.,..., Garcia-Rill, E.
(2015)
. Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse. Sleep Science, 8(3), 162-168.
http://dx.doi.org/10.1016/j.slsci.2015.09.004---------- CHICAGO ----------
Urbano, F.J., Bisagno, V., González, B., Rivero-Echeto, M.C., MuñIz, J.A., Luster, B., et al.
"Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse"
. Sleep Science 8, no. 3
(2015) : 162-168.
http://dx.doi.org/10.1016/j.slsci.2015.09.004---------- MLA ----------
Urbano, F.J., Bisagno, V., González, B., Rivero-Echeto, M.C., MuñIz, J.A., Luster, B., et al.
"Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse"
. Sleep Science, vol. 8, no. 3, 2015, pp. 162-168.
http://dx.doi.org/10.1016/j.slsci.2015.09.004---------- VANCOUVER ----------
Urbano, F.J., Bisagno, V., González, B., Rivero-Echeto, M.C., MuñIz, J.A., Luster, B., et al. Pedunculopontine arousal system(Ft physiology—effects of psychostimulant abuse. Sleep Sci. 2015;8(3):162-168.
http://dx.doi.org/10.1016/j.slsci.2015.09.004