Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia. © 2015 Brazilian Association of Sleep.

Registro:

Documento: Artículo
Título:Pedunculopontine arousal system physiology - Implications for insomnia
Autor:Garcia-Rilla, E.; Lustera, B.; Mahaffeya, S.; Bisagnoh, V.; Urhanob, F.J.
Filiación:Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States
IFIBYNE-CONICET and ININFA-CONICET, University of Buenos, Aires, Argentina
Palabras clave:Calcium channels; Gamma band activity; N-type calcium channel; Neuronal calcium sensor protein; P/Q-type calcium channel; benzodiazepine derivative; calcium calmodulin dependent protein kinase II; calcium channel N type; calcium channel P type; calcium channel Q type; cyclic AMP dependent protein kinase; hypnotic agent; kainic acid; lithium; n methyl dextro aspartic acid; n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide; neuronal calcium sensor; omega agatoxin IVA; omega conotoxin GVIA; protein kinase C; unclassified drug; arousal; Article; bipolar disorder; cognitive therapy; daytime somnolence; electroencephalography; habituation; hallucination; hippocampus; human; insomnia; nightmare; pedunculopontine tegmental nucleus; REM sleep; reticular formation; schizophrenia; sleep waking cycle; substantia nigra pars compacta; wakefulness
Año:2015
Volumen:8
Número:2
Página de inicio:92
Página de fin:99
DOI: http://dx.doi.org/10.1016/j.slsci.2015.06.002
Título revista:Sleep Science
Título revista abreviado:Sleep Sci.
ISSN:19840659
CAS:calcium calmodulin dependent protein kinase II, 141467-21-2; cyclic AMP dependent protein kinase; kainic acid, 487-79-6; lithium, 7439-93-2; n methyl dextro aspartic acid, 6384-92-5; omega conotoxin GVIA, 107407-86-3; protein kinase C, 141436-78-4; protein kinase C theta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p92_GarciaRilla

Referencias:

  • International classification of sleep disorders (2014) 3Rd Ed.: Diagnostic and Coding Manual, , American Academy of Sleep Medicine: Westchester, Illinois
  • Garcia-Rill, E., Waking and the Reticular Activating System In, 330. , New York: Academic Press
  • Kripke, D.F., Garfinkel, L., Wingard, D.L., Klauber, M.R., Marler, M.R., Mortality associated with sleep duration and insomnia (2002) Arch Gen Psychiatry, 59, p. 131
  • Dauvilliers, Y., Morin, C., Cervena, K., Carlander, B., Touchon, J., Besset, A., Family studies in insomnia (2005) J Psychosom Res, 58, p. 271
  • Bonnet, M.H., Arand, D.L., Hyperarousal and insomnia: State of the science (2010) Sleep Med Rev, 14, p. 9
  • Riemann, D., Spiegelhalder, K., Feige, B., Vodeholzer, U., Berger, M., Perils, M., The hyperarousal model of insomnia: A review of the concept and its evidence (2010) Sleep Med Rev, 14, p. 19
  • Cervena, K., Espa, F., Perogamvros, L., Perrig, S., Merica, H., Ibanez, V., Spectral analysis of the sleep onset period in primary insomnia (2014) Clin Neurophysiol, 125, p. 979
  • Baglioni, C., Regen, W., Teghen, A., Spiegelhalder, K., Feige, B., Nissen, C., Sleep changes in the disorder of insomnia: A meta-analysis of polysomnographic studies (2014) Sleep Med Rev, 18, p. 195
  • Feige, B., Baglioni, C., Spiegelhalder, K., Hirscher, V., Nissen, C., Riemann, D., The microstructure of sleep in primary insomnia: An overview and extension (2013) Int J Psychophysiol, 89, pp. 171-180
  • Perlis, M.L., Smith, M.T., Rews, P.J., Orff, H., Giles, D.E., Beta/ gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls (2001) Sleep, 24, pp. 110-117
  • Spiegelhalder, K., Regen, W., Feige, B., Holz, J., Piosczyk, H., Baglioni, C., Increased EEG sigma and beta power during NREM sleep in primary insomnia (2012) Biol Psychol, 91, pp. 329-333
  • Garcia-Rill, E., Heister, D.S., Ye, M., Charlesworth, A., Hayar, A., Electrical coupling: Novel mechanism for sleep-wake control (2007) Sleep, 30, pp. 1405-1414
  • Garcia-Rill, E., Kezunovic, N., Hyde, J., Beck, P., Urbano, F.J., Coherence and frequency in the reticular activating system (RAS) (2013) Sleep Med Rev, 17, pp. 227-238
  • Steriade, M., McCarley, R.W., (1990) Brainstem Control of Wakefulness and Sleep, , New York, NY: Plenum Press
  • Wang, H.L., Morales, M., Pedunculopontine and laterodorsal tegmental nuclei contan distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat (2009) Eur J Neurosci, 29, pp. 340-358
  • Leonard, C.S., Llinas, R.R., Electrophysiology of mammalian pedunculopontine and laterodorsal tegmental neurons in vitro: Implications for the control of REM sleep (1990) Brain Cholinergic Systems, pp. 205-223. , Steriade M, Biesold D, Oxford: Oxford Science
  • Kamondi, A., Williams, J., Hutcheon, B., Reiner, P., Membrane properties of mesopontine cholinergic neurons studied with the whole-cell patch-clamp technique: Implications for behavioral state control (1992) J Neurophysiol, 68, pp. 1359-1372
  • Takakusaki, K., Kitai, S.T., Ionic mechanisms involved in the spontaneous firing of tegmental pedunculopontine nucleus neurons of the rat (1997) Neuroscience, 78, pp. 771-794
  • Steriade, M., Paré, D., Datta, S., Oakson, G., Dossi, R., Curro. Different cellular types in mesopontine cholinergic nuclei related to ponto-geniculo-occipital waves (1990) J Neurosci, 10, pp. 2560-2579
  • Sakai, K., El Mansari, M., Jouvet, M., Inhibition by carbachol microinjections of presumptive cholinergic PGO-on neurons in freely moving cats (1990) Brain Res, 527, pp. 213-223
  • Steriade, M., Datta, S., Paré, D., Oakson, G., Dossi, R., Curro. Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems (1990) J Neurosci, 10, pp. 2541-2559
  • Datta, S., Siwek, D.F., Single cell activity patterns of pedunculopontine tegmentum neurons across the sleep- wake cycle in the freely moving rats (2002) J Neurosci Res, 70, pp. 79-82
  • Steriade, M., Curro Dossi, R., Pare, D., Oakson, D.G., Fast oscillations (20-40 Hz) in thalamocortical systems and their potentiation by mesopontine cholinergic nuclei in the cat (1991) Proc Nat Acad Sci, 88, pp. 4396-4400
  • Simon, C., Kezunovic, N., Ye, M., Hyde, J., Hayar, A., Williams, D.K., Gamma band unit and population responses in the pedunculopontine nucleus (2010) J Neurophysiol, 104, pp. 463-474
  • Kezunovic, N., Urbano, F.J., Simon, C., Hyde, J., Smith, K., Garcia-Rill, E., Mechanism behind gamma band activity in the pedunculopontine nucleus (PPN) (2011) Eur J Neurosci, 34, pp. 404-415
  • Pedroarena, C., Llinás, R.R., Dendritic calcium conductances generate high-frequency oscillation in thalamocortical neurons (1997) Proc Nat Acad Sci, 94, pp. 724-728
  • Hyde, J., Kezunovic, N., Urbano, F.J., Garcia-Rill, E., Spatiotemporal properties of high speed calcium oscillations in the pedunculopontine nucleus (2013) J Appl Physiol, 115, pp. 1402-1414
  • Datta, S., Evidence That, R., Sleep is controlled by the activation of brain stem pedunculopontine tegmental kainate receptor (2002) J Neurophysiol, 87, pp. 1790-1798
  • Datta, S., Siwek, D.F., Excitation of the brain stem pedunculopontine tegmentum cholinergic cells induce wakefulness and REM sleep (1997) J Neurophysiol, 77, pp. 2975-2988
  • Datta, S., Spoley, E.E., Patterson, E.H., Microinjection of glutamate into the pedunculopontine tegmentum induces REM sleep and wakefulness in the rat (2001) Am J Physiol Regul Integr Comp Physiol, 280, pp. R752-R759
  • Datta, S., Patterson, E.H., Spoley, E.E., Excitation of pedunculopontine tegmental NMDA receptors induces wakefulness and cortical activation in the rat (2001) J Neurosci Res, 66, p. 109
  • Data, S., O’Malley, M.W., Patterson, E.H., Calcium/calmodulin kinase II in the pedunculopontine tegmental nucleus modulates the initiation and maintenance of wakefulness (2010) J Neurosci, 31, pp. 1700-1716
  • Desarnaud, F., Macone, B.W., Datta, S., Activation of extracellular signal-regulated kinase signaling in the pedunculopontine tegmental cells is involved in the maintenance of sleep in rats (2011) J Neurochem, 116, pp. 577-587
  • Datta, S., Desarnaud, F., Protein kinase A in the pedunculopontine tegmental nucleus of rat contributes to regulation of rapid eye movement sleep (2010) J Neurosci, 30, pp. 12263-12273
  • Datta, S., Siwek, D.F., Stack, E.C., Identification of cholinergic and non-cholinergic neurons in the pons expressing phosphorylated cyclic adenosine monophosphate response element-binding protein as a function of rapid eye movement sleep (2009) Neuroscience, 163, pp. 397-414
  • Luster, B., Hyde, J., Donofrio, S., Urbano, F.J., Garcia-Rill, E., Mechanisms behind gamma band activity in the pedunculopontine nucleus (PPN) (2014) Neurosci Abstr, 38, p. 257
  • Luster, B., D’Onofrio, S., Urbano, F.J., Garcia-Rill, E., High-threshold Ca2+ channels behind gamma band activity in the pedunculopontine nucleus (PPN) (2015) Physiol Rep, 3
  • Ishikawa, T., Kaneko, M., Shin, H.S., Takahashi, T., Presynaptic N- type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of held of mice (2005) J Physiol, 568, pp. 199-209
  • Reid, C.A., Bekker, J.M., Clement, J.D., Presynaptic Ca2+ channels: A functional patchwork (2003) Trends Neurosci, 26, pp. 683-687
  • Pietrobon, D., Function and dysfunction of synaptic Ca2+ channels: Insights from mouse models (2005) Curr Opin Neurobiol, 15, pp. 257-265
  • Jun, K., Piedras-Renteria, E.S., Smith, S.M., Wheeler, D.B., Lee, S.B., Lee, T.G., Ablation of P/Q-type Ca2+ channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the a1A-subunit (1999) Proc Natl Acad Sci, 96, pp. 15245-15250
  • Llinas, R.R., Choi, S., Urbano, F.J., Shin, H.S., Gamma band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice (2007) Proc Natl Acad Sci, 104, pp. 17819-17824
  • Agler, H.L., Evans, J., Colecraft, H.M., Yue, D.T., Custom distinctions in the interaction of G-protein b subunits with N-type (Cav2.2) versus P/Q-type (Cav2. 1) Ca2+ channels (2003) J Gen Physiol, 121, pp. 495-510
  • Stea, A., Soomg, T.W., Snutch, T.P., Determinants of PKC- dependent modulation of a family of neuronal Ca2+ channels (1995) Neuron, 15, pp. 929-940
  • Jiang, X., Lautermilch, N.J., Watari, H., Westenbroek, R.E., Scheuer, T., Catterall, W.A., Modulation of Cav2.1 channels by Ca+/ calmodulin-dependent kinase II bound to the C-terminal domain (2008) Proc Natl Acad Sci, 105, pp. 341-346
  • D’Onofrio, S., Kezunovic, N., Hyde, J., Luster, B., Messias, E., Urbano, F.J., Modulation of gamma oscillations in the pedunculopontine nucleus (PPN) by neuronal calcium sensor protein-1 (NCS-1): Relevance to schizophrenia and bipolar disorder (2015) J Neurophysiol, 113, pp. 709-719
  • Garcia-Rill, E., Kezunovic, N., D’Onofrio, S., Luster, B., Hyde, J., Bisagno, V., Gamma band activity in the RAS- intracellular mechanisms (2014) Exp Brain Res, 232, pp. 1509-1522
  • Koh, P.O., Undie, A.S., Kabbani, N., Levenson, R., Goldman-Rakic, P., Lidow, M.S., Up-regulation of neuronal calcium sensor-1 (NCS- 1) in the prefrontal cortex of schizophrenic and bipolar patients (2003) Proc Natl Acad Sci, 100, pp. 313-317
  • D’Onofrio, S., Urbano, F.J., Garcia-Rill, E., Liithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons (2015) Neurosci Abstr, 39 (257). , 19
  • Muldoon, A.F., Soltesz, I., Cossart, R.R., Spatially clustered neuronal assemblies comprise the microstructure of synchrony in chronically epileptic networks (2013) Proc Nat Acad Sci, 110, pp. 3567-3572
  • Buzsaki, G., Neural syntax: Cell assemblies, synapsembles, and readers (2010) Neuron, 68, pp. 362-385

Citas:

---------- APA ----------
Garcia-Rilla, E., Lustera, B., Mahaffeya, S., Bisagnoh, V. & Urhanob, F.J. (2015) . Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Science, 8(2), 92-99.
http://dx.doi.org/10.1016/j.slsci.2015.06.002
---------- CHICAGO ----------
Garcia-Rilla, E., Lustera, B., Mahaffeya, S., Bisagnoh, V., Urhanob, F.J. "Pedunculopontine arousal system physiology - Implications for insomnia" . Sleep Science 8, no. 2 (2015) : 92-99.
http://dx.doi.org/10.1016/j.slsci.2015.06.002
---------- MLA ----------
Garcia-Rilla, E., Lustera, B., Mahaffeya, S., Bisagnoh, V., Urhanob, F.J. "Pedunculopontine arousal system physiology - Implications for insomnia" . Sleep Science, vol. 8, no. 2, 2015, pp. 92-99.
http://dx.doi.org/10.1016/j.slsci.2015.06.002
---------- VANCOUVER ----------
Garcia-Rilla, E., Lustera, B., Mahaffeya, S., Bisagnoh, V., Urhanob, F.J. Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Sci. 2015;8(2):92-99.
http://dx.doi.org/10.1016/j.slsci.2015.06.002