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Abstract:

Schizophrenia is characterized by major sleep/wake disturbances including increased vigi­lance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal- related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of distur­bances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia. © 2015 Brazilian Association of Sleep.

Registro:

Documento: Artículo
Título:Pedunculopontine arousal system physiology—implications for schizophrenia
Autor:Garcia-Rilla, E.; D’onofrioa, S.; Mahaffeya, S.; Bisagnob, V.; Urbanob, F.J.
Filiación:Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States
IFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:Calcium channels; Gamma band activity; Neuronal calcium sensor protein; P50 potential; 4 aminobutyric acid; calcium channel N type; calcium channel P type; calcium channel Q type; chlorpromazine; clozapine; dopamine; haloperidol; lithium; modafinil; muscarinic receptor; n methyl dextro aspartic acid; n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide; neuronal calcium sensor; olanzapine; serotonin receptor; tetrodotoxin; unclassified drug; arousal; Article; bipolar disorder; dyskinesia; human; Parkinson disease; pedunculopontine tegmental nucleus; physiology; REM sleep; reticular formation; schizophrenia; substantia nigra; thalamus; wakefulness
Año:2015
Volumen:8
Número:2
Página de inicio:82
Página de fin:91
DOI: http://dx.doi.org/10.1016/j.slsci.2015.04.003
Título revista:Sleep Science
Título revista abreviado:Sleep Sci.
ISSN:19840659
CAS:4 aminobutyric acid, 28805-76-7, 56-12-2; chlorpromazine, 50-53-3, 69-09-0; clozapine, 5786-21-0; dopamine, 51-61-6, 62-31-7; haloperidol, 52-86-8, 1511-16-6; lithium, 7439-93-2; modafinil, 68693-11-8; n methyl dextro aspartic acid, 6384-92-5; olanzapine, 132539-06-1; tetrodotoxin, 4368-28-9, 4664-41-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p82_GarciaRilla

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Citas:

---------- APA ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V. & Urbanob, F.J. (2015) . Pedunculopontine arousal system physiology—implications for schizophrenia. Sleep Science, 8(2), 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003
---------- CHICAGO ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V., Urbanob, F.J. "Pedunculopontine arousal system physiology—implications for schizophrenia" . Sleep Science 8, no. 2 (2015) : 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003
---------- MLA ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V., Urbanob, F.J. "Pedunculopontine arousal system physiology—implications for schizophrenia" . Sleep Science, vol. 8, no. 2, 2015, pp. 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003
---------- VANCOUVER ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V., Urbanob, F.J. Pedunculopontine arousal system physiology—implications for schizophrenia. Sleep Sci. 2015;8(2):82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003