Abstract:
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal- related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia. © 2015 Brazilian Association of Sleep.
Registro:
Documento: |
Artículo
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Título: | Pedunculopontine arousal system physiology—implications for schizophrenia |
Autor: | Garcia-Rilla, E.; D’onofrioa, S.; Mahaffeya, S.; Bisagnob, V.; Urbanob, F.J. |
Filiación: | Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States IFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | Calcium channels; Gamma band activity; Neuronal calcium sensor protein; P50 potential; 4 aminobutyric acid; calcium channel N type; calcium channel P type; calcium channel Q type; chlorpromazine; clozapine; dopamine; haloperidol; lithium; modafinil; muscarinic receptor; n methyl dextro aspartic acid; n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide; neuronal calcium sensor; olanzapine; serotonin receptor; tetrodotoxin; unclassified drug; arousal; Article; bipolar disorder; dyskinesia; human; Parkinson disease; pedunculopontine tegmental nucleus; physiology; REM sleep; reticular formation; schizophrenia; substantia nigra; thalamus; wakefulness |
Año: | 2015
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Volumen: | 8
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Número: | 2
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Página de inicio: | 82
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Página de fin: | 91
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DOI: |
http://dx.doi.org/10.1016/j.slsci.2015.04.003 |
Título revista: | Sleep Science
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Título revista abreviado: | Sleep Sci.
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ISSN: | 19840659
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CAS: | 4 aminobutyric acid, 28805-76-7, 56-12-2; chlorpromazine, 50-53-3, 69-09-0; clozapine, 5786-21-0; dopamine, 51-61-6, 62-31-7; haloperidol, 52-86-8, 1511-16-6; lithium, 7439-93-2; modafinil, 68693-11-8; n methyl dextro aspartic acid, 6384-92-5; olanzapine, 132539-06-1; tetrodotoxin, 4368-28-9, 4664-41-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p82_GarciaRilla |
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Citas:
---------- APA ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V. & Urbanob, F.J.
(2015)
. Pedunculopontine arousal system physiology—implications for schizophrenia. Sleep Science, 8(2), 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003---------- CHICAGO ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V., Urbanob, F.J.
"Pedunculopontine arousal system physiology—implications for schizophrenia"
. Sleep Science 8, no. 2
(2015) : 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003---------- MLA ----------
Garcia-Rilla, E., D’onofrioa, S., Mahaffeya, S., Bisagnob, V., Urbanob, F.J.
"Pedunculopontine arousal system physiology—implications for schizophrenia"
. Sleep Science, vol. 8, no. 2, 2015, pp. 82-91.
http://dx.doi.org/10.1016/j.slsci.2015.04.003---------- VANCOUVER ----------
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