Abstract:
Pioneering work showed that serotonin (5-HT) neurons have the unique capacity to engage in different and opposed aspects of motivated behaviors such as reward and punishment responses. These findings provided strong evidence about the functional heterogeneity of 5-HT neurons, and their possible engagement in multiple and behaviorally distinct neural subsystems. A recent study provides further compelling evidence supporting this notion, in which two ascending 5-HT circuits modulate opposed aspects of motivated behaviors. © 2018 American Chemical Society.
Registro:
Documento: |
Artículo
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Título: | Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions |
Autor: | Garcia-Garcia, A.L.; Soiza-Reilly, M. |
Filiación: | Department of Psychiatry, Division of Systems Neuroscience, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr. Box 87, New York, NY 10032, United States Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | 5-HT; Amygdala; Chemogenetics; Frontal Cortex; Optogenetics; Punishment; Reward |
Año: | 2018
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DOI: |
http://dx.doi.org/10.1021/acschemneuro.8b00534 |
Título revista: | ACS Chemical Neuroscience
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Título revista abreviado: | ACS Chem. Neurosci.
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ISSN: | 19487193
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CODEN: | ACNCD
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19487193_v_n_p_GarciaGarcia |
Referencias:
- Ren, J., Friedmann, D., Xiong, J., Liu, C.D., Ferguson, B.R., Weerakkody, T., Deloach, K.E., Luo, L., Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems (2018) Cell, 175, p. 472
- Cohen, J.Y., Amoroso, M.W., Uchida, N., Serotonergic neurons signal reward and punishment on multiple timescales (2015) ELife, 4, p. e06346
- Li, Y., Zhong, W., Wang, D., Feng, Q., Liu, Z., Zhou, J., Jia, C., Luo, M., Serotonin neurons in the dorsal raphe nucleus encode reward signals (2016) Nat. Commun., 7, p. 10503
- Garcia-Garcia, A.L., Canetta, S., Stujenske, J.M., Burghardt, N.S., Ansorge, M.S., Dranovsky, A., Leonardo, E.D., Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner (2017) Mol. Psychiatry
- Marcinkiewcz, C.A., Mazzone, C.M., D'Agostino, G., Halladay, L.R., Hardaway, J.A., Diberto, J.F., Navarro, M., Kash, T.L., Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala (2016) Nature, 537, pp. 97-101
Citas:
---------- APA ----------
Garcia-Garcia, A.L. & Soiza-Reilly, M.
(2018)
. Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions. ACS Chemical Neuroscience.
http://dx.doi.org/10.1021/acschemneuro.8b00534---------- CHICAGO ----------
Garcia-Garcia, A.L., Soiza-Reilly, M.
"Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions"
. ACS Chemical Neuroscience
(2018).
http://dx.doi.org/10.1021/acschemneuro.8b00534---------- MLA ----------
Garcia-Garcia, A.L., Soiza-Reilly, M.
"Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions"
. ACS Chemical Neuroscience, 2018.
http://dx.doi.org/10.1021/acschemneuro.8b00534---------- VANCOUVER ----------
Garcia-Garcia, A.L., Soiza-Reilly, M. Serotonin Subsystems Modulate Diverse and Opposite Behavioral Functions. ACS Chem. Neurosci. 2018.
http://dx.doi.org/10.1021/acschemneuro.8b00534