Cabrera, R.; Filevich, O.; García-Acosta, B.; Athilingam, J.; Bender, K.J.; Poskanzer, K.E.; Etchenique, R."A Visible-Light-Sensitive Caged Serotonin" (2017) ACS Chemical Neuroscience. 8(5):1036-1042
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Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. © 2017 American Chemical Society.


Documento: Artículo
Título:A Visible-Light-Sensitive Caged Serotonin
Autor:Cabrera, R.; Filevich, O.; García-Acosta, B.; Athilingam, J.; Bender, K.J.; Poskanzer, K.E.; Etchenique, R.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CONICET, Ciudad Universitaria Pabellón 2, EHA Buenos Aires, AR1428, Argentina
Ciclo Básico Común, Universidad de Buenos Aires, Buenos Aires, 1053, Argentina
Laboratorio de Neurobiología Molecular, BIOMED, Pontificia Universidad Católica Argentina, CONICET, Buenos Aires, C1107AFB, Argentina
Kavli Institute for Fundamental Neuroscience, UCSF Weill Institute for Neuroscience, San Francisco, CA, United States
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, United States
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, United States
Palabras clave:neurophysiology; phototriggers; Ruthenium complex; serotonin; serotonin; ruthenium; serotonin; animal cell; Article; light absorption; mouse; nerve cell excitability; nonhuman; pH; photochemistry; photolysis; photosensitivity; priority journal; proton nuclear magnetic resonance; pyramidal nerve cell; quantum yield; animal; chemistry; drug effects; light; metabolism; nerve cell; prefrontal cortex; Animals; Light; Mice; Neurons; Prefrontal Cortex; Ruthenium; Serotonin
Página de inicio:1036
Página de fin:1042
Título revista:ACS Chemical Neuroscience
Título revista abreviado:ACS Chem. Neurosci.
CAS:serotonin, 50-67-9; ruthenium, 7440-18-8; Ruthenium; Serotonin


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---------- APA ----------
Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E. & Etchenique, R. (2017) . A Visible-Light-Sensitive Caged Serotonin. ACS Chemical Neuroscience, 8(5), 1036-1042.
---------- CHICAGO ----------
Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E., et al. "A Visible-Light-Sensitive Caged Serotonin" . ACS Chemical Neuroscience 8, no. 5 (2017) : 1036-1042.
---------- MLA ----------
Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E., et al. "A Visible-Light-Sensitive Caged Serotonin" . ACS Chemical Neuroscience, vol. 8, no. 5, 2017, pp. 1036-1042.
---------- VANCOUVER ----------
Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E., et al. A Visible-Light-Sensitive Caged Serotonin. ACS Chem. Neurosci. 2017;8(5):1036-1042.