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Jiang, P.; Ventura, A.C.; Sontag, E.D.; Merajver, S.D.; Ninfa, A.J.; Del Vecchio, D. "Load-induced modulation of signal transduction networks" (2011) Science Signaling. 4(194)
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Abstract:

Biological signal transduction networks are commonly viewed as circuits that pass along information - in the process amplifying signals, enhancing sensitivity, or performing other signal-processing tasks - to transcriptional and other components. Here, we report on a "reverse-causality" phenomenon, which we call load-induced modulation. Through a combination of analytical and experimental tools, we discovered that signaling was modulated, in a surprising way, by downstream targets that receive the signal and, in doing so, apply what in physics is called a load. Specifically, we found that non-intuitivechanges in response dynamics occurred for a covalent modification cycle when load was present.Loading altered the response time of a system, depending on whether the activity of one of the enzymeswas maximal and the other was operating at its minimal rate or whether both enzymes were operating atsubmaximal rates. These two conditions, which we call "limit regime" and "intermediate regime," wereassociated with increased or decreased response times, respectively. The bandwidth, the range of frequencyin which the system can process information, decreased in the presence of load, suggesting thatdownstream targets participate in establishing a balance between noise-filtering capabilities and a circuit'sability to process high-frequency stimulation. Nodes in a signaling network are not independentrelay devices, but rather are modulated by their downstream targets.

Registro:

Documento: Artículo
Título:Load-induced modulation of signal transduction networks
Autor:Jiang, P.; Ventura, A.C.; Sontag, E.D.; Merajver, S.D.; Ninfa, A.J.; Del Vecchio, D.
Filiación:Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, United States
Institute for Physiology, Molecular Biology, and Neuroscience, Department of Biology, Universidad de Buenos Aires, Pabellón 2, Buenos Aires C1428EHA, Argentina
Department of Mathematics, Rutgers University, New Brunswick, NJ 08854-8019, United States
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, United States
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Palabras clave:article; enzyme activity; information processing; mathematical model; modulation; priority journal; signal processing; signal transduction; allosterism; biological model; Escherichia coli; feedback system; metabolism; physiology; systems biology; time; enzyme; nitrogen regulatory protein; nucleotidyltransferase; regulatory protein uridylyltransferase; Allosteric Regulation; Enzymes; Escherichia coli; Feedback, Physiological; Models, Biological; Nucleotidyltransferases; PII Nitrogen Regulatory Proteins; Signal Transduction; Systems Biology; Time Factors
Año:2011
Volumen:4
Número:194
DOI: http://dx.doi.org/10.1126/scisignal.2002152
Título revista:Science Signaling
Título revista abreviado:Sci. Signal.
ISSN:19450877
CAS:nucleotidyltransferase, 9031-50-9; Enzymes; Nucleotidyltransferases, 2.7.7.-; PII Nitrogen Regulatory Proteins; regulatory protein uridylyltransferase, 2.7.7.59
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450877_v4_n194_p_Jiang

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Citas:

---------- APA ----------
Jiang, P., Ventura, A.C., Sontag, E.D., Merajver, S.D., Ninfa, A.J. & Del Vecchio, D. (2011) . Load-induced modulation of signal transduction networks. Science Signaling, 4(194).
http://dx.doi.org/10.1126/scisignal.2002152
---------- CHICAGO ----------
Jiang, P., Ventura, A.C., Sontag, E.D., Merajver, S.D., Ninfa, A.J., Del Vecchio, D. "Load-induced modulation of signal transduction networks" . Science Signaling 4, no. 194 (2011).
http://dx.doi.org/10.1126/scisignal.2002152
---------- MLA ----------
Jiang, P., Ventura, A.C., Sontag, E.D., Merajver, S.D., Ninfa, A.J., Del Vecchio, D. "Load-induced modulation of signal transduction networks" . Science Signaling, vol. 4, no. 194, 2011.
http://dx.doi.org/10.1126/scisignal.2002152
---------- VANCOUVER ----------
Jiang, P., Ventura, A.C., Sontag, E.D., Merajver, S.D., Ninfa, A.J., Del Vecchio, D. Load-induced modulation of signal transduction networks. Sci. Signal. 2011;4(194).
http://dx.doi.org/10.1126/scisignal.2002152