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Medina, V.A.; Brenzoni, P.G.; Lamas, D.J.M.; Massari, N.; Mondillo, C.; Nunez, M.A.; Pignataro, O.; Rivera, E.S. "Role of histamine H4 receptor in breast cancer cell proliferation" (2011) Frontiers in Bioscience - Elite. 3 E(3):1042-1060
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Abstract:

In order to better understand the role of histamine H4 (H4R) receptor in breast cancer, we studied the receptor expression pattern, associated signal transduction pathway and biological responses, in breast cancer cell lines with different malignant characteristics. A different pattern of protein expression was observed in MDA-MB-231 compared to MCF-7 cells determined by western blot, exhibiting the presence of a diverse range of molecular weight species of the H4R. H4R agonist reduced cyclic adenosine monophosphate (cAMP) formation induced by forskolin only in MCF-7 cells. In MDA-MB-231 cells, H4R agonists significantly decreased cell roliferation, augmented the Annexin-V and TdT-mediated UTP-biotin Nick End labelling (TUNEL) positive cells and produced a 2.5-fold increase in cell senescence. In MCF-7 cells, H4R agonists inhibited proliferation by 50%, increasing the exponential doubling time. This effect was associated to an augment in Annexin-V and TUNEL positive cells, and a 2-fold increase in cell senescence. We conclude that H4R is functionally expressed in human breast cancer cell lines, exhibiting a key role in histaminemediated biological processes such as cell proliferation, senescence and apoptosis.

Registro:

Documento: Artículo
Título:Role of histamine H4 receptor in breast cancer cell proliferation
Autor:Medina, V.A.; Brenzoni, P.G.; Lamas, D.J.M.; Massari, N.; Mondillo, C.; Nunez, M.A.; Pignataro, O.; Rivera, E.S.
Filiación:Laboratory of Radioisotopes, School of Pharmacy and Biochemistry, University of Buenos Aires, Junin 956, Buenos Aires, 1113, Argentina
National Scientific and Technical Research Council (Conicet), Buenos Aires, Argentina
Laboratory of Molecular Endocrinology and Signal Transduction, Institute of Biology and Experimental Medicine-Conicet, Buenos Aires, 1428, Argentina
Palabras clave:Apoptosis; Cell Senescence; Histamine H4 Receptor; Human Breast Cancer; Proliferation; 1 (5 chloro 2 indolylcarbonyl) 4 methylpiperazine; 1 [2 (amidinothio)ethyl]guanidine; clobenpropit; cyclic AMP; histamine; histamine H3 receptor antagonist; histamine H4 receptor; lipocortin 5; unclassified drug; G protein coupled receptor; histamine receptor; HRH4 protein, human; primer DNA; apoptosis; article; breast cancer; cancer cell culture; cell aging; cell proliferation; controlled study; human; human cell; nick end labeling; protein expression; signal transduction; breast tumor; female; nucleotide sequence; pathology; physiology; reverse transcription polymerase chain reaction; tumor cell line; Western blotting; Apoptosis; Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Primers; Female; Humans; In Situ Nick-End Labeling; Receptors, G-Protein-Coupled; Receptors, Histamine; Reverse Transcriptase Polymerase Chain Reaction
Año:2011
Volumen:3 E
Número:3
Página de inicio:1042
Página de fin:1060
Título revista:Frontiers in Bioscience - Elite
Título revista abreviado:Front. Biosci. Elite
ISSN:19450494
CAS:clobenpropit, 145231-45-4; cyclic AMP, 60-92-4; histamine, 51-45-6, 56-92-8, 93443-21-1; histamine H4 receptor, 272100-58-0; lipocortin 5, 111237-10-6; DNA Primers; HRH4 protein, human; Receptors, G-Protein-Coupled; Receptors, Histamine
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v3E_n3_p1042_Medina

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Citas:

---------- APA ----------
Medina, V.A., Brenzoni, P.G., Lamas, D.J.M., Massari, N., Mondillo, C., Nunez, M.A., Pignataro, O.,..., Rivera, E.S. (2011) . Role of histamine H4 receptor in breast cancer cell proliferation. Frontiers in Bioscience - Elite, 3 E(3), 1042-1060.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v3E_n3_p1042_Medina [ ]
---------- CHICAGO ----------
Medina, V.A., Brenzoni, P.G., Lamas, D.J.M., Massari, N., Mondillo, C., Nunez, M.A., et al. "Role of histamine H4 receptor in breast cancer cell proliferation" . Frontiers in Bioscience - Elite 3 E, no. 3 (2011) : 1042-1060.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v3E_n3_p1042_Medina [ ]
---------- MLA ----------
Medina, V.A., Brenzoni, P.G., Lamas, D.J.M., Massari, N., Mondillo, C., Nunez, M.A., et al. "Role of histamine H4 receptor in breast cancer cell proliferation" . Frontiers in Bioscience - Elite, vol. 3 E, no. 3, 2011, pp. 1042-1060.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v3E_n3_p1042_Medina [ ]
---------- VANCOUVER ----------
Medina, V.A., Brenzoni, P.G., Lamas, D.J.M., Massari, N., Mondillo, C., Nunez, M.A., et al. Role of histamine H4 receptor in breast cancer cell proliferation. Front. Biosci. Elite. 2011;3 E(3):1042-1060.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v3E_n3_p1042_Medina [ ]