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Abstract:

Successful implantation requires a functionally normal embryo at the blastocyst stage and a receptive endometrium as well as adequate communication between them throughout the implantation process. This cross-talk is highly regulated by a number of different kinds of molecules. Particularly, chemokines-small polypeptides that attract specific leukocyte subsets by binding to cellsurface receptors- are also required to maintain immuneprivileged sites as the feto-maternal interface. Chemokines expression involves an interdependent network with the absence of a single chemokine affecting the expression of multiple other chemokines, we have chosen to focus on just two representative examples: RANTES (regulated on normal T cell expressed and secreted) and MCP-1 (Monocyte chemo-attractant protein). Here, we present updated information on their expression levels and regulation on three different levels: 1) systemic effects on maternal allogeneic response; 2) local effects on endometrial cells; and 3) during an early stage of the feto-maternal dialogue. For each of the three levels, we analyzed data from both fertile women and patients having experienced recurrent spontaneous abortions as representative of physiological and pathological situations respectively.

Registro:

Documento: Artículo
Título:Immunomodulatory effects of chemokines during the early implantation window
Autor:Fraccaroli, L.; Alfieri, J.; Leiros, C.P.; Ramhorst, R.
Filiación:Laboratory of Immunopharmacology, School of Exact and Natural Sciences, University of Buenos Aires, Int Guiraldes 2160, Ciudad Uni, Pabellon 2 Piso 4, (C1428EHA) Buenos Aires, Argentina
Immunogenetics Laboratory, School of Medicine, University of Buenos Aires, Av. Cordoba 2351, Buenos Aires, Argentina
Palabras clave:Chemokines; Pregnancy; Recurrent spontaneous abortions; Review; Tolerance; chemokine; immunologic factor; RANTES; cytology; drug effect; endometrium; female; fetomaternal transfusion; histocompatibility; human; immunology; metabolism; nidation; pregnancy; recurrent abortion; review; T lymphocyte; Abortion, Habitual; Chemokine CCL5; Chemokines; Embryo Implantation; Endometrium; Female; Histocompatibility, Maternal-Fetal; Humans; Immunologic Factors; Maternal-Fetal Exchange; Pregnancy; T-Lymphocytes
Año:2009
Volumen:1 E
Número:1
Página de inicio:288
Página de fin:298
Título revista:Frontiers in Bioscience - Elite
Título revista abreviado:Front. Biosci. Elite
ISSN:19450494
CAS:Chemokine CCL5; Chemokines; Immunologic Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v1E_n1_p288_Fraccaroli

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Citas:

---------- APA ----------
Fraccaroli, L., Alfieri, J., Leiros, C.P. & Ramhorst, R. (2009) . Immunomodulatory effects of chemokines during the early implantation window. Frontiers in Bioscience - Elite, 1 E(1), 288-298.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v1E_n1_p288_Fraccaroli [ ]
---------- CHICAGO ----------
Fraccaroli, L., Alfieri, J., Leiros, C.P., Ramhorst, R. "Immunomodulatory effects of chemokines during the early implantation window" . Frontiers in Bioscience - Elite 1 E, no. 1 (2009) : 288-298.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v1E_n1_p288_Fraccaroli [ ]
---------- MLA ----------
Fraccaroli, L., Alfieri, J., Leiros, C.P., Ramhorst, R. "Immunomodulatory effects of chemokines during the early implantation window" . Frontiers in Bioscience - Elite, vol. 1 E, no. 1, 2009, pp. 288-298.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v1E_n1_p288_Fraccaroli [ ]
---------- VANCOUVER ----------
Fraccaroli, L., Alfieri, J., Leiros, C.P., Ramhorst, R. Immunomodulatory effects of chemokines during the early implantation window. Front. Biosci. Elite. 2009;1 E(1):288-298.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450494_v1E_n1_p288_Fraccaroli [ ]