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Abstract:

Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be locally regulated upon synapse activity and we have recently shown that the exoribonuclease XRN1 forms dynamic aggregates at the post synapse that respond to specific stimuli.1 These foci were termed SX-bodies and are distinct from stress granules (SGs), processing bodies (PBs) and other RNA granules previously described. Together with Smaug1-foci and FMRP-granules, the SX-bodies contribute to dynamically shape the transcriptome available for translation at the post-synapse. © 2016 María Gabriela Thomas and Graciela Lidia Boccaccio.

Registro:

Documento: Artículo
Título:Novel mRNA-silencing bodies at the synapse: A never-ending story
Autor:Thomas, M.G.; Boccaccio, G.L.
Filiación:Fundación Instituto LeloirBuenos Aires, Argentina
Instituto de Investigaciones Bioquímicas Buenos Aires-Consejo Nacional de Investigaciones Científicas y TecnológicasBuenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, University of Buenos AiresBuenos Aires, Argentina
Palabras clave:DHPG; FMRP; NMDA; Samd4; Smaug; XRN1
Año:2016
Volumen:9
Número:2
Página de inicio:1
Página de fin:5
DOI: http://dx.doi.org/10.1080/19420889.2016.1139251
Título revista:Communicative and Integrative Biology
Título revista abreviado:Commun. Integr. Biol.
ISSN:19420889
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v9_n2_p1_Thomas

Referencias:

  • Luchelli, L., Thomas, M.G., Boccaccio, G.L., Synaptic control of mRNA translation by reversible assembly of XRN1 bodies (2015) J Cell Sci, 128, pp. 1542-1554. , http://dx.doi.org/10.1242/jcs.163295, PMID:25736288
  • Arribas-Layton, M., Wu, D., Lykke-Andersen, J., Song, H., Structural and functional control of the eukaryotic mRNA decapping machinery (2013) Biochim Biophys Acta, 1829, pp. 580-589. , http://dx.doi.org/10.1016/j.bbagrm.2012.12.006, PMID:23287066
  • Thomas, M.G., Loschi, M., Desbats, M.A., Boccaccio, G.L., RNA granules: The good, the bad and the ugly (2011) Cell Signal, 23, pp. 324-334. , http://dx.doi.org/10.1016/j.cellsig.2010.08.011, PMID:20813183
  • Ramaswami, M., Taylor, J.P., Parker, R., Altered ribostasis: RNA-protein granules in degenerative disorders (2013) Cell, 154, pp. 727-736. , http://dx.doi.org/10.1016/j.cell.2013.07.038, PMID:23953108
  • Buchan, J.R., Parker, R., Eukaryotic stress granules: The ins and outsoftranslation (2009) Mol Cell, 36, pp. 932-941. , http://dx.doi.org/10.1016/j.molcel.2009.11.020, PMID:20064460
  • Franks, T.M., Lykke-Andersen, J., The control of mRNA decapping and P-body formation (2008) Mol Cell, 32, pp. 605-615. , http://dx.doi.org/10.1016/j.molcel.2008.11.001, PMID:19061636
  • Tom Dieck, S., Hanus, C., Schuman, E.M., SnapShot: Local protein translation in dendrites (2014) Neuron, 81, p. 958. , http://dx.doi.org/10.1016/j.neuron.2014.02.009, PMID:24559682
  • Schuman, E.M., Dynes, J.L., Steward, O., Synaptic regulation of translation of dendritic mRNAs (2006) J Neurosci, 26, pp. 7143-7146. , http://dx.doi.org/10.1523/JNEUROSCI.1796-06.2006, PMID:16822969
  • Holt, C.E., Schuman, E.M., The central dogma decentralized: New perspectives on RNA function and local translation in neurons (2013) Neuron, 80, pp. 648-657. , http://dx.doi.org/10.1016/j.neuron.2013.10.036, PMID:24183017
  • Pascual, M.L., Luchelli, L., Habif, M., Boccaccio, G.L., Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse (2012) Commun Integr Biol, 5, pp. 388-392. , http://dx.doi.org/10.4161/cib.20257, PMID: 23060966
  • Zhou, M., Bail, S., Plasterer, H.L., Rusche, J., Kiledjian, M., DcpS is a transcript-specific modulator of RNA in mammalian cells (2015) RNA, 21, pp. 1306-1312. , http://dx.doi.org/10.1261/rna.051573.115, PMID:26001796
  • Grousl, T., Opekarova, M., Stradalova, V., Hasek, J., Malinsky, J., Evolutionarily conserved 50-30 exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast (2015) Plos One, 10. , http://dx.doi.org/10.1371/journal.pone.0122770, PMID:25811606
  • Haimovich, G., Medina, D.A., Causse, S.Z., Garber, M., Millan-Zambrano, G., Barkai, O., Chavez, S., Choder, M., Gene expression is circular: Factors for mRNA degradation also foster mRNA synthesis (2013) Cell, 153, pp. 1000-1011. , http://dx.doi.org/10.1016/j.cell.2013.05.012, PMID:23706738
  • Baez, M.V., Luchelli, L., Maschi, D., Habif, M., Pascual, M., Thomas, M.G., Boccaccio, G.L., Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation (2011) J Cell Biol, 195, pp. 1141-1157. , http://dx.doi.org/10.1083/jcb.201108159, PMID:22201125
  • Amadei, G., Zander, M.A., Yang, G., Dumelie, J.G., Vessey, J.P., Lipshitz, H.D., Smibert, C.A., Miller, F.D., A Smaug2-based translational repression complex determines the balance between precursor maintenance versus differentiation during mammalian neurogenesis (2015) J Neurosci, 35, pp. 15666-15681. , http://dx.doi.org/10.1523/JNEUROSCI.2172-15.2015, PMID:26609159
  • Pimentel, J., Boccaccio, G.L., Translation and silencing in RNA granules: A tale of sand grains (2014) Front Mol Neurosci, 7, p. 68. , http://dx.doi.org/10.3389/fnmol.2014.00068, PMID:25100944
  • Thomas, M.G., Pascual, M.L., Maschi, D., Luchelli, L., Boccaccio, G.L., Synaptic control of local translation: The plot thickens with new characters (2014) Cell Mol Life Sci, 71, pp. 2219-2239. , http://dx.doi.org/10.1007/s00018-013-1506-y, PMID:24212248
  • Sosanya, N.M., Cacheaux, L.P., Workman, E.R., Niere, F., Perrone-Bizzozero, N.I., Raab-Graham, K.F., Mammalian target of rapamycin (MTOR) tagging promotes dendritic branch variability through the capture of Ca2C/Calmodulin-dependent protein kinase II alpha (CaMKIIalpha) mRNAs by the RNA-binding Protein HuD (2015) J Biol Chem, 290, pp. 16357-16371. , http://dx.doi.org/10.1074/jbc.M114.599399, PMID:25944900
  • Loschi, M., Leishman, C.C., Berardone, N., Boccaccio, G.L., Dynein and kinesin regulate stress-granule and P-body dynamics (2009) J Cell Sci, 122, pp. 3973-3982. , http://dx.doi.org/10.1242/jcs.051383, PMID:19825938
  • Bullock, S.L., Messengers, motors and mysteries: Sorting of eukaryotic mRNAs by cytoskeletal transport (2011) Biochem Soc Trans, 39, pp. 1161-1165. , http://dx.doi.org/10.1042/BST0391161, PMID:21936782
  • Kato, M., Han, T.W., Xie, S., Shi, K., Du, X., Wu, L.C., Mirzaei, H., Pei, J., Cell-free formation of RNA granules: Low complexity sequence domains form dynamic fibers within hydrogels (2012) Cell, 149, pp. 753-767. , http://dx.doi.org/10.1016/j.cell.2012.04.017, PMID:22579281
  • Jonas, S., Izaurralde, E., The role of disordered protein regions in the assembly of decapping complexes and RNP granules (2013) Genes Dev, 27, pp. 2628-2641. , http://dx.doi.org/10.1101/gad.227843.113, PMID:24352420
  • Molliex, A., Temirov, J., Lee, J., Coughlin, M., Kanagaraj, A.P., Kim, H.J., Mittag, T., Taylor, J.P., Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization (2015) Cell, 163, pp. 123-133. , http://dx.doi.org/10.1016/j.cell.2015.09.015, PMID:26406374
  • Murakami, T., Qamar, S., Lin, J.Q., Schierle, G.S., Rees, E., Miyashita, A., Costa, A.R., Michel, C.H., ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function (2015) Neuron, 88, pp. 678-690. , http://dx.doi.org/10.1016/j.neuron.2015.10.030, PMID:26526393
  • Lin, Y., Protter, D.S., Rosen, M.K., Parker, R., Formation andmaturation of phase-separated liquid droplets by RNA-binding proteins (2015) Mol Cell, 60, pp. 208-219. , http://dx.doi.org/10.1016/j.molcel.2015.08.018, PMID:26412307
  • Elbaum-Garfinkle, S., Brangwynne, C.P., Liquids, fibers, and gels: The many phases of neurodegeneration (2015) Dev Cell, 35, pp. 531-532. , http://dx.doi.org/10.1016/j.devcel.2015.11.014, PMID:26651288
  • Lee, C.D., Tu, B.P., Glucose-regulated phosphorylation of the PUF protein Puf3 regulates the translational fate of its bound mRNAs and association with RNA granules (2015) Cell Rep, 11, pp. 1638-1650. , http://dx.doi.org/10.1016/j.celrep.2015.05.014, PMID:26051939
  • Khan, M.R., Li, L., Perez-Sanchez, C., Saraf, A., Florens, L., Slaughter, B.D., Unruh, J.R., Si, K., Amyloidogenic oligomerization transforms drosophila Orb2 from a translation repressor to an activator (2015) Cell, 163, pp. 1468-1483. , http://dx.doi.org/10.1016/j.cell.2015.11.020, PMID:26638074
  • Schaefer, M.H., Wanker, E.E., Andrade-Navarro, M.A., Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks (2012) Nucleic Acids Res, 40, pp. 4273-4287. , http://dx.doi.org/10.1093/nar/gks011, PMID:22287626
  • Cougot, N., Bhattacharyya, S.N., Tapia-Arancibia, L., Bordonne, R., Filipowicz, W., Bertrand, E., Rage, F., Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation (2008) J Neurosci, 28, pp. 13793-13804. , http://dx.doi.org/10.1523/JNEUROSCI.4155-08.2008, PMID:19091970
  • Beckmann, B.M., Horos, R., Fischer, B., Castello, A., Eichelbaum, K., Alleaume, A.M., Schwarzl, T., Huber, W., The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs (2015) Nat Commun, 6, p. 10127. , http://dx.doi.org/10.1038/ncomms10127, PMID:26632259

Citas:

---------- APA ----------
Thomas, M.G. & Boccaccio, G.L. (2016) . Novel mRNA-silencing bodies at the synapse: A never-ending story. Communicative and Integrative Biology, 9(2), 1-5.
http://dx.doi.org/10.1080/19420889.2016.1139251
---------- CHICAGO ----------
Thomas, M.G., Boccaccio, G.L. "Novel mRNA-silencing bodies at the synapse: A never-ending story" . Communicative and Integrative Biology 9, no. 2 (2016) : 1-5.
http://dx.doi.org/10.1080/19420889.2016.1139251
---------- MLA ----------
Thomas, M.G., Boccaccio, G.L. "Novel mRNA-silencing bodies at the synapse: A never-ending story" . Communicative and Integrative Biology, vol. 9, no. 2, 2016, pp. 1-5.
http://dx.doi.org/10.1080/19420889.2016.1139251
---------- VANCOUVER ----------
Thomas, M.G., Boccaccio, G.L. Novel mRNA-silencing bodies at the synapse: A never-ending story. Commun. Integr. Biol. 2016;9(2):1-5.
http://dx.doi.org/10.1080/19420889.2016.1139251