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Abstract:

Regulation of alternative splicing is coupled to transcription quality, the polymerase elongation rate being an important factor in modulating splicing choices. In a recently published work, we provide evidence that intragenic histone acetylation patterns can be affected by neural cell excitation in order to regulate alternative splicing of the neural cell adhesion molecule (NCAM) mRNA. This example illustrates how an extracellular stimulus can influence transcription-coupled alternative splicing, strengthening the link between chromatin structure, transcriptional elongation and mRNA processing. ©2009 Landes Bioscience.

Registro:

Documento: Artículo
Título:Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation
Autor:Schor, I.E.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología y Biología Molecular; Departamento de Fisiología, Biología Molecular y Celular; IFIBYNE-UBA-CONICET; Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires; Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Alternative splicing; Chromatin; Histone acetylation; NCAM; Neuronal excitation; Structure; Transcriptional elongation
Año:2009
Volumen:2
Número:4
Página de inicio:341
Página de fin:343
DOI: http://dx.doi.org/10.4161/cib.2.4.8550
Título revista:Communicative and Integrative Biology
Título revista abreviado:Commun. Integr. Biol.
ISSN:19420889
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_19420889_v2_n4_p341_Schor.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19420889_v2_n4_p341_Schor

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Citas:

---------- APA ----------
Schor, I.E. & Kornblihtt, A.R. (2009) . Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation. Communicative and Integrative Biology, 2(4), 341-343.
http://dx.doi.org/10.4161/cib.2.4.8550
---------- CHICAGO ----------
Schor, I.E., Kornblihtt, A.R. "Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation" . Communicative and Integrative Biology 2, no. 4 (2009) : 341-343.
http://dx.doi.org/10.4161/cib.2.4.8550
---------- MLA ----------
Schor, I.E., Kornblihtt, A.R. "Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation" . Communicative and Integrative Biology, vol. 2, no. 4, 2009, pp. 341-343.
http://dx.doi.org/10.4161/cib.2.4.8550
---------- VANCOUVER ----------
Schor, I.E., Kornblihtt, A.R. Playing inside the genes: Intragenic histone acetylation after membrane depolarization of neural cells opens a path for alternative splicing regulation. Commun. Integr. Biol. 2009;2(4):341-343.
http://dx.doi.org/10.4161/cib.2.4.8550