Artículo
García, C.C.; Acosta, E.G.; Carro, A.C.; Belmonte, M.C.F.; Bomben, R.; Duschatzky, C.B.; Perotti, M.; Schuff, C.; Damonte, E.B. "Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina" (2010) Natural Product Communications. 5(8):1307-1310
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Abstract:
The essential oils of seven aromatic plants from central west Argentina were isolated by steam distillation and analyzed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV). The oils showed a variable virucidal action according to the virus. JUNV was the least susceptible virus in comparison with HSV-1 and DENV-2. The better relationship between cytotoxicity and inhibitory activity was observed for the essential oil of Lantana grisebachiii (Seckt.) var. grisebachii against DENV-2 and HSV-1 with IC50 (inhibitory concentration 50%) values of 21.1 and 26.1 ppm, respectively. This effect was specific since the selectivity indices (ratio cytotoxicity/virucidal activity) were > 23.7 and > 19.1 for DENV-2 and HSV-1, respectively. Furthermore, the oil from L. grisebachii was also an effective inhibitor of HSV-2 and acyclovir resistant variants of herpes virus. This study demonstrates the effective and selective inhibitory activity of the essential oil from Lantana grisebachii against HSV and DENV by direct virus inactivation.
Registro:
| Documento: | Artículo |
| Título: | Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| Autor: | García, C.C.; Acosta, E.G.; Carro, A.C.; Belmonte, M.C.F.; Bomben, R.; Duschatzky, C.B.; Perotti, M.; Schuff, C.; Damonte, E.B. |
| Filiación: | Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina FICES, Universidad Nacional de San Luis, 25 de Mayo 384, 5730 Villa Mercedes, Argentina Facultad de Bioquímica, Química Y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, 4000 San Miguel de Tucumán, Argentina |
| Palabras clave: | Dengue virus; Essential oil; Herpes simplex virus; Junin virus; Virucidal activity; essential oil; Lantana grisebachii essential oil; unclassified drug; antivirus agent; essential oil; animal cell; antiviral activity; article; chemical composition; controlled study; Dengue virus 2; distillation; drug cytotoxicity; drug isolation; Herpes simplex virus 1; IC 50; Junin virus; Lantana; Lantana grisebachii; nonhuman; virus inactivation; virus strain; Argentina; chemistry; Dengue virus; drug effects; isolation and purification; medicinal plant; Dengue virus; Dengue virus type 2; Herpesviridae; Human herpesvirus 1; Human herpesvirus 2; Junin virus; Lantana; Simplexvirus; Antiviral Agents; Argentina; Dengue Virus; Herpesvirus 1, Human; Junin virus; Lantana; Oils, Volatile; Plants, Medicinal |
| Año: | 2010 |
| Volumen: | 5 |
| Número: | 8 |
| Página de inicio: | 1307 |
| Página de fin: | 1310 |
| Título revista: | Natural Product Communications |
| Título revista abreviado: | Nat. Pro. Comm. |
| ISSN: | 1934578X |
| CAS: | Antiviral Agents; Oils, Volatile |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1934578X_v5_n8_p1307_Garcia |
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Citas:
---------- APA ----------
García, C.C., Acosta, E.G., Carro, A.C., Belmonte, M.C.F., Bomben, R., Duschatzky, C.B., Perotti, M.,..., Damonte, E.B. (2010) . Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina. Natural Product Communications, 5(8), 1307-1310.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1934578X_v5_n8_p1307_Garcia [ ]
---------- CHICAGO ----------
García, C.C., Acosta, E.G., Carro, A.C., Belmonte, M.C.F., Bomben, R., Duschatzky, C.B., et al. "Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina" . Natural Product Communications 5, no. 8 (2010) : 1307-1310.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1934578X_v5_n8_p1307_Garcia [ ]
---------- MLA ----------
García, C.C., Acosta, E.G., Carro, A.C., Belmonte, M.C.F., Bomben, R., Duschatzky, C.B., et al. "Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina" . Natural Product Communications, vol. 5, no. 8, 2010, pp. 1307-1310.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1934578X_v5_n8_p1307_Garcia [ ]
---------- VANCOUVER ----------
García, C.C., Acosta, E.G., Carro, A.C., Belmonte, M.C.F., Bomben, R., Duschatzky, C.B., et al. Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina. Nat. Pro. Comm. 2010;5(8):1307-1310.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1934578X_v5_n8_p1307_Garcia [ ]
