Artículo

Lobo Maza, F.; Méndez De Leo, L.; Rubert, A.A.; Carro, P.; Salvarezza, R.C.; Vericat, C. "New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)" (2016) Journal of Physical Chemistry C. 120(27):14597-14607
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Abstract:

In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and X-ray photoelectron spectroscopy. Results from polarization modulation infrared reflection-absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6-mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface. © 2016 American Chemical Society.

Registro:

Documento: Artículo
Título:New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)
Autor:Lobo Maza, F.; Méndez De Leo, L.; Rubert, A.A.; Carro, P.; Salvarezza, R.C.; Vericat, C.
Filiación:Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de la Plata - CONICET Sucursal 4, Casilla de Correo 16, La Plata, 1900, Argentina
DQIAyQF, INQUIMAE-CONICET, Facultad Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Buenos Aires, C1428EHA, Argentina
Área de Química Física, Departamento de Química, Facultad de Ciencias, Universidad de la Laguna, Instituto de Materiales y Nanotecnología, Avenida Francisco Sánchez, s/n, La Laguna, Tenerife, 38071, Spain
Palabras clave:Absorption spectroscopy; Cyclic voltammetry; Gold; Medical applications; Monolayers; Peptides; Photodegradation; X ray photoelectron spectroscopy; 6-mercaptopurine (6MP); Biomedical applications; Drug delivery applications; Interface chemistry; Phosphate buffers; Polarization modulation infrared reflection absorption spectroscopy; Triggered release; Vibrational bands; Self assembled monolayers
Año:2016
Volumen:120
Número:27
Página de inicio:14597
Página de fin:14607
DOI: http://dx.doi.org/10.1021/acs.jpcc.5b12643
Título revista:Journal of Physical Chemistry C
Título revista abreviado:J. Phys. Chem. C
ISSN:19327447
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19327447_v120_n27_p14597_LoboMaza

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Citas:

---------- APA ----------
Lobo Maza, F., Méndez De Leo, L., Rubert, A.A., Carro, P., Salvarezza, R.C. & Vericat, C. (2016) . New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111). Journal of Physical Chemistry C, 120(27), 14597-14607.
http://dx.doi.org/10.1021/acs.jpcc.5b12643
---------- CHICAGO ----------
Lobo Maza, F., Méndez De Leo, L., Rubert, A.A., Carro, P., Salvarezza, R.C., Vericat, C. "New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)" . Journal of Physical Chemistry C 120, no. 27 (2016) : 14597-14607.
http://dx.doi.org/10.1021/acs.jpcc.5b12643
---------- MLA ----------
Lobo Maza, F., Méndez De Leo, L., Rubert, A.A., Carro, P., Salvarezza, R.C., Vericat, C. "New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111)" . Journal of Physical Chemistry C, vol. 120, no. 27, 2016, pp. 14597-14607.
http://dx.doi.org/10.1021/acs.jpcc.5b12643
---------- VANCOUVER ----------
Lobo Maza, F., Méndez De Leo, L., Rubert, A.A., Carro, P., Salvarezza, R.C., Vericat, C. New insight into the interface chemistry and stability of glutathione self-assembled monolayers on Au(111). J. Phys. Chem. C. 2016;120(27):14597-14607.
http://dx.doi.org/10.1021/acs.jpcc.5b12643