Artículo

Sedeño, L.; Couto, B.; Melloni, M.; Canales-Johnson, A.; Yoris, A.; Baez, S.; Esteves, S.; Velásquez, M.; Barttfeld, P.; Sigman, M.; Kichic, R.; Chialvo, D.; Manes, F.; Bekinschtein, T.A.; Ibanez, A. "How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder" (2014) PLoS ONE. 9(6)
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Abstract:

Depersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception - defined as the cognitive processing of body signals - has been extensively considered as a key processing for body self-awareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient's impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings. © 2014 Sedeño et al.

Registro:

Documento: Artículo
Título:How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder
Autor:Sedeño, L.; Couto, B.; Melloni, M.; Canales-Johnson, A.; Yoris, A.; Baez, S.; Esteves, S.; Velásquez, M.; Barttfeld, P.; Sigman, M.; Kichic, R.; Chialvo, D.; Manes, F.; Bekinschtein, T.A.; Ibanez, A.
Filiación:Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina
UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile
Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
Physics Department, Laboratory of Integrative Neuroscience, FCEyN UBA and IFIBA, Buenos Aires, Argentina
Anxiety Clinic, INECO (Institute of Cognitive Neurology), Buenos Aires, Argentina
National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina
Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France
Universidad Torcuato di Tella, Buenos Aires, Argentina
Departamento de Matemáticas y Ciencias, Universidad de San Andrés, Buenos Aires, Argentina
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States
Universidad Autónoma del Caribe, Barranquilla, Colombia
Australian Research Council (ACR) Centre of Excellence in Cognition and Its Disorders, Macquarie University, Sydney, NSW, Australia
Palabras clave:adult; article; body mass; case report; cognition; controlled study; demography; depersonalization derealization disorder; dissociative disorder; emotion; emotional processing; empathy; functional connectivity; functional magnetic resonance imaging; Heartbeat Detection Task; human; interoception; male; nervous system parameters; neuropsychological test; questionnaire; self report; social aspect; somatosensory disorder; symptom; task performance; young adult; brain; case control study; connectome; depersonalization; heart rate; interoception; pathophysiology; psychology; Brain; Case-Control Studies; Connectome; Depersonalization; Emotions; Empathy; Heart Rate; Humans; Interoception; Male; Young Adult
Año:2014
Volumen:9
Número:6
DOI: http://dx.doi.org/10.1371/journal.pone.0098769
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
CODEN:POLNC
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v9_n6_p_Sedeno

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Citas:

---------- APA ----------
Sedeño, L., Couto, B., Melloni, M., Canales-Johnson, A., Yoris, A., Baez, S., Esteves, S.,..., Ibanez, A. (2014) . How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder. PLoS ONE, 9(6).
http://dx.doi.org/10.1371/journal.pone.0098769
---------- CHICAGO ----------
Sedeño, L., Couto, B., Melloni, M., Canales-Johnson, A., Yoris, A., Baez, S., et al. "How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder" . PLoS ONE 9, no. 6 (2014).
http://dx.doi.org/10.1371/journal.pone.0098769
---------- MLA ----------
Sedeño, L., Couto, B., Melloni, M., Canales-Johnson, A., Yoris, A., Baez, S., et al. "How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder" . PLoS ONE, vol. 9, no. 6, 2014.
http://dx.doi.org/10.1371/journal.pone.0098769
---------- VANCOUVER ----------
Sedeño, L., Couto, B., Melloni, M., Canales-Johnson, A., Yoris, A., Baez, S., et al. How do you feel when you can't feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorder. PLoS ONE. 2014;9(6).
http://dx.doi.org/10.1371/journal.pone.0098769