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Abstract:

Several reports have shown that after specific reminders are presented, consolidated memories pass from a stable state to one in which the memory is reactivated. This reactivation implies that memories are labile and susceptible to amnesic agents. This susceptibility decreases over time and leads to a re-stabilization phase usually known as reconsolidation. With respect to the biological role of reconsolidation, two functions have been proposed. First, the reconsolidation process allows new information to be integrated into the background of the original memory; second, it strengthens the original memory. We have previously demonstrated that both of these functions occur in the reconsolidation of human declarative memories. Our paradigm consisted of learning verbal material (lists of five pairs of nonsense syllables) acquired by a training process (L1-training) on Day 1 of our experiment. After this declarative memory is consolidated, it can be made labile by presenting a specific reminder. After this, the memory passes through a subsequent stabilization process. Strengthening creates a new scenario for the reconsolidation process; this function represents a new factor that may transform the dynamic of memories. First, we analyzed whether the repeated labilization-reconsolidation processes maintained the memory for longer periods of time. We showed that at least one labilization-reconsolidation process strengthens a memory via evaluation 5 days after its re-stabilization. We also demonstrated that this effect is not triggered by retrieval only. We then analyzed the way strengthening modified the effect of an amnesic agent that was presented immediately after repeated labilizations. The repeated labilization-reconsolidation processes made the memory more resistant to interference during re-stabilization. Finally, we evaluated whether the effect of strengthening may depend on the age of the memory. We found that the effect of strengthening did depend on the age of the memory. Forgetting may represent a process that weakens the effect of strengthening. © 2013 Forcato et al.

Registro:

Documento: Artículo
Título:The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?
Autor:Forcato, C.; Fernandez, R.S.; Pedreira, M.E.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Buenos Aires, Argentina
Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany
Palabras clave:adult; article; association; declarative memory; human; learning; memory consolidation; task performance; training; verbal behavior; Adolescent; Adult; Cues; Female; Humans; Male; Memory, Long-Term; Memory, Short-Term; Time Factors; Verbal Learning
Año:2013
Volumen:8
Número:4
DOI: http://dx.doi.org/10.1371/journal.pone.0061688
Handle:http://hdl.handle.net/20.500.12110/paper_19326203_v8_n4_p_Forcato
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_19326203_v8_n4_p_Forcato.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v8_n4_p_Forcato

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Citas:

---------- APA ----------
Forcato, C., Fernandez, R.S. & Pedreira, M.E. (2013) . The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?. PLoS ONE, 8(4).
http://dx.doi.org/10.1371/journal.pone.0061688
---------- CHICAGO ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?" . PLoS ONE 8, no. 4 (2013).
http://dx.doi.org/10.1371/journal.pone.0061688
---------- MLA ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. "The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?" . PLoS ONE, vol. 8, no. 4, 2013.
http://dx.doi.org/10.1371/journal.pone.0061688
---------- VANCOUVER ----------
Forcato, C., Fernandez, R.S., Pedreira, M.E. The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?. PLoS ONE. 2013;8(4).
http://dx.doi.org/10.1371/journal.pone.0061688