Artículo

Ibanez, A.; Cetkovich, M.; Petroni, A.; Urquina, H.; Baez, S.; Gonzalez-Gadea, M.L.; Kamienkowski, J.E.; Torralva, T.; Torrente, F.; Strejilevich, S.; Teitelbaum, J.; Hurtado, E.; Guex, R.; Melloni, M.; Lischinsky, A.; Sigman, M.; Manes, F. "The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)" (2012) PLoS ONE. 7(5)
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Abstract:

Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems. © 2012 Ibanez et al.

Registro:

Documento: Artículo
Título:The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
Autor:Ibanez, A.; Cetkovich, M.; Petroni, A.; Urquina, H.; Baez, S.; Gonzalez-Gadea, M.L.; Kamienkowski, J.E.; Torralva, T.; Torrente, F.; Strejilevich, S.; Teitelbaum, J.; Hurtado, E.; Guex, R.; Melloni, M.; Lischinsky, A.; Sigman, M.; Manes, F.
Filiación:Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina
National Scientific and Technical Research Council, Buenos Aires, Argentina
Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales, Santiago, Chile
Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Buenos Aires, Argentina
Pontificia Universidad Católica de Chile, Santiago, Chile
Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
Neurored, Universidad Surcolombiana, Neiva, Colombia
Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland
Palabras clave:adult; anterior cingulate; article; attention deficit disorder; behavior; bipolar disorder; clinical article; controlled study; decision making; event related potential; executive function; feedback system; female; human; hyperactivity; impulsiveness; Iowa Gambling Task; learning disorder; male; mood disorder; motivation; neurobiology; neurophysiology; neuropsychological test; rapid decision gambling task; response time; reward; working memory; analysis of variance; biological model; cingulate gyrus; learning; pathological gambling; pathophysiology; physiology; reinforcement; reward; risk; Filicophyta; Adult; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Decision Making; Gambling; Gyrus Cinguli; Humans; Learning; Models, Neurological; Neuropsychological Tests; Reinforcement (Psychology); Reward; Risk
Año:2012
Volumen:7
Número:5
DOI: http://dx.doi.org/10.1371/journal.pone.0037306
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n5_p_Ibanez

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Citas:

---------- APA ----------
Ibanez, A., Cetkovich, M., Petroni, A., Urquina, H., Baez, S., Gonzalez-Gadea, M.L., Kamienkowski, J.E.,..., Manes, F. (2012) . The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD). PLoS ONE, 7(5).
http://dx.doi.org/10.1371/journal.pone.0037306
---------- CHICAGO ----------
Ibanez, A., Cetkovich, M., Petroni, A., Urquina, H., Baez, S., Gonzalez-Gadea, M.L., et al. "The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)" . PLoS ONE 7, no. 5 (2012).
http://dx.doi.org/10.1371/journal.pone.0037306
---------- MLA ----------
Ibanez, A., Cetkovich, M., Petroni, A., Urquina, H., Baez, S., Gonzalez-Gadea, M.L., et al. "The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)" . PLoS ONE, vol. 7, no. 5, 2012.
http://dx.doi.org/10.1371/journal.pone.0037306
---------- VANCOUVER ----------
Ibanez, A., Cetkovich, M., Petroni, A., Urquina, H., Baez, S., Gonzalez-Gadea, M.L., et al. The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD). PLoS ONE. 2012;7(5).
http://dx.doi.org/10.1371/journal.pone.0037306