Artículo

Este artículo es de Acceso Abierto y puede ser descargado en su versión final desde nuestro repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The idea that memories are immutable after consolidation has been challenged. Several reports have shown that after the presentation of a specific reminder, reactivated old memories become labile and again susceptible to amnesic agents. Such vulnerability diminishes with the progress of time and implies a re-stabilization phase, usually referred to as reconsolidation. To date, the main findings describe the mechanisms associated with the labilization-reconsolidation process, but little is known about its functionality from a biological standpoint. Indeed, two functions have been proposed. One suggests that destabilization of the original memory after the reminder allows the integration of new information into the background of the original memory (memory updating), and the other suggests that the labilization-reconsolidation process strengthens the original memory (memory strengthening). We have previously reported the reconsolidation of human declarative memories, demonstrating memory updating in the framework of reconsolidation. Here we deal with the strengthening function attributed to the reconsolidation process. We triggered labilization-reconsolidation processes successively by repeated presentations of the proper reminder. Participants learned an association between five cue-syllables and their respective response-syllables. Twenty-four hours later, the paired-associate verbal memory was labilized by exposing the subjects to one, two or four reminders. The List-memory was evaluated on Day 3 showing that the memory was improved when at least a second reminder was presented in the time window of the first labilization-reconsolidation process prompted by the earlier reminder. However, the improvement effect was revealed on Day 3, only when at least two reminders were presented on Day2 and not as a consequence of only retrieval. Therefore, we propose central concepts for the reconsolidation process, emphasizing its biological role and the parametrical constrains for this function to be operative. © 2011 Forcato et al.

Registro:

Documento: Artículo
Título:Repeated labilization-reconsolidation processes strengthen declarative memory in humans
Autor:Forcato, C.; Rodríguez, M.L.C.; Pedreira, M.E.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE - CONICET, Buenos Aires, Argentina
Palabras clave:adult; analysis of variance; article; association; brain function; controlled study; declarative memory; human; human experiment; information processing; learning; memory consolidation; mental performance; normal human; verbal memory; working memory; clinical trial; controlled clinical trial; female; long term memory; male; memory; physiology; randomized controlled trial; recall; Adult; Female; Humans; Male; Memory; Mental Recall; Retention (Psychology); Young Adult
Año:2011
Volumen:6
Número:8
DOI: http://dx.doi.org/10.1371/journal.pone.0023305
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_19326203_v6_n8_p_Forcato.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v6_n8_p_Forcato

Referencias:

  • Barlett, F., Remembering: A study in Experimental and social Psychology (1932), Mc Millan; Schacter, D.L., Norman, K.A., Koutstaal, W., The cognitive neuroscience of constructive memory (1998) Annu Rev Psychol, 149, pp. 289-318
  • Brown, R., Kulik, J., Flashbulb memories (1977) Cognition, 5, pp. 73-79
  • Loftus, E.F., Miller, D.G., Burns, H.J., Semantic integration of verbal information into a visual memory (1978) J Exp Psychol Hum Learn Mem, 4, pp. 19-31
  • Müller, G.E., Pilzecker, A., Experimentelle beitrage zur lerhe Vom gedachtnis (1900) Z Psychol., (SUPPL. 1)
  • Squire, L.R., Alvarez, P., Retrograde amnesia and memory consolidation: a neurobiological perspective (1995) Curr Opin Neurobiol, 5, pp. 169-177
  • Bailey, C.H., Bartsch, D., Kandel, E.R., Toward a molecular definition of long-term memory storage (1996) Proc Natl Acad Sci USA, 93, pp. 13445-13452
  • McGaugh, J.L., Memory--a century of consolidation (2000) Science, 287, pp. 248-251
  • Dudai, Y., Memory from A to Z. Keywords, Concepts and Beyond (2002), Oxford., UK, Oxford UP; McGaugh, J., Time-dependent processes in memory storage (1966) Science, 153, pp. 1351-1358
  • Kandel, E.R., The molecular biology of memory storage: a dialog between genes and synapses (2001) Biosci Rep, 21, pp. 565-611
  • Davis, H.P., Squire, L.R., Protein synthesis and memory: a review (1984) Psychol Bull, 96, pp. 518-559
  • Misanin, J.R., Miller, R.R., Lewis, D.J., Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace (1968) Science, 160, pp. 554-555
  • Alberini, C.M., Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? (2005) Trends Neurosci, 28, pp. 51-56
  • Alberini, C.M., Reconsolidation: the samsara of memory consolidation (2007) Deb Neurosci, 1, pp. 17-24
  • Lewis, D.J., Psychobiology of active and inactive memory (1979) Psychol Bull, 86, pp. 1054-1083
  • Dudai, Y., The neurobiology of consolidations, or, how stable is the engram? (2004) Ann Rev Psychol, 55, pp. 51-86
  • Sara, S.J., Retrieval and reconsolidation: toward a neurobiology of remembering (2000) Learn Mem, 7, pp. 73-84
  • Milekic, M.H., Alberini, C.M., Temporally graded requirement for protein synthesis following memory reactivation (2002) Neuron, 236, pp. 521-525
  • Pedreira, M.E., Maldonado, H., Protein synthesis subserves reconsolidation or extinction depending on reminder duration (2003) Neuron, 38, pp. 863-869
  • Pedreira, M.E., Perez-Cuesta, L.M., Maldonado, H., Mismatch between what is expected and what actually occurs triggers memory reconsolidation or extinction (2004) Learn Mem, 11, pp. 579-585
  • Suzuki, A., Josselyn, S.A., Frankland, P.W., Masushige, S., Silva, A.J., Memory reconsolidation and extinction have distinct temporal and biochemical signatures (2004) J Neurosci, 24, pp. 4787-4795
  • Morris, R.G., Inglis, J., Ainge, J.A., Olverman, H.J., Tulloch, J., Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval (2006) Neuron, 50, pp. 479-489
  • Rodriguez-Ortiz, C.J., de la Cruz, V., Gutierrez, R., Bermudez-Rattoni, F., Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained (2005) Learn Mem, 12, pp. 533-537
  • Lee, J.L., Memory reconsolidation mediates the updating of hippocampal memory content (2010) Front Behav Neurosci, 4, p. 168
  • Lee, J.L., Memory reconsolidation mediates the strengthening of memories by additional learning (2008) Nat Neurosci, 11 (11), pp. 1264-1266
  • Hupbach, A., Gomez, R., Hardt, O., Nadel, L., Reconsolidation of episodic memories: a subtle reminder triggers integration of new information (2007) Learn Mem, 14, pp. 47-53
  • Inda, M.C., Muravieva, E.V., Alberini, C.M., Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction (2011) J Neurosci, 31, pp. 1635-1643
  • Forcato, C., Burgos, V.L., Argibay, P.F., Molina, V.A., Pedreira, M.E., Reconsolidation of declarative memory in humans (2007) Learn Mem, 14, pp. 295-303
  • Tulving, E., Episodic and semantic memory (1972), In: Tulving E, Donaldson W, Organization of memory, editors, New York, Academic Press; Schacter, D.L., Tulving, E., Memory, amnesia, and the episodic/semantic distinction (1982) Expression of Knowledge, pp. 33-65. , In: Isaacson RL, Spear NE, editors, New York, Plenum
  • Forcato, C., Argibay, P.F., Pedreira, M.E., Maldonado, H., Human reconsolidation does not always occur when a memory is retrieved: the relevance of the reminder structure (2009) Neurobiol Learn Mem, 91, pp. 50-57
  • Forcato, C., Rodríguez, M.L., Pedreira, M.E., Maldonado, H., Reconsolidation in humans opens up declarative memory to the entrance of new information (2010) Neurobiol Learn Mem, 93, pp. 77-84
  • Nader, K., Schafe, G.E., LeDoux, J.E., Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval (2000) Nature, 406, pp. 722-726
  • Coccoz, V., Maldonado, H., Delorenzi, A., The enhancement of reconsolidation with a naturalistic mild stressor improves the expression of a declarative memory in humans (2011) Neurosci, 185, pp. 61-72
  • Bustos, S.G., Maldonado, H., Molina, V.A., Midazolam disrupts fear memory reconsolidation (2006) Neurosci, 139, pp. 831-842
  • Duvarci, S., Nader, K., Characterization of fear memory reconsolidation (2004) J Neurosci, 24, pp. 9269-9275
  • Lee, J.L., Reconsolidation: maintaining memory relevance (2009) Trends Neurosci, 32, pp. 413-420
  • Myers, K.M., Davis, M., Behavioral and neural analysis of extinction (2002) Neuron, 36, pp. 567-584
  • Eisenberg, M., Kobilo, T., Berman, D.E., Dudai, Y., Stability of retrieved memory: inverse correlation with trace dominance (2003) Science, 301, pp. 1102-1104
  • Schiller, D., Monfils, M.H., Raio, C.M., Johnson, D.C., Ledoux, J.E., Preventing the return of fear in humans using reconsolidation update mechanisms (2010) Nature, 463, pp. 49-53
  • Kindt, M., Soeter, M., Vervliet, B., Beyond extinction: erasing human fear responses and preventing the return of fear (2009) Nature Neurosci, 12, pp. 256-258
  • Rasch, B., Born, J., Maintaining memories by reactivation (2007) Current Op Neurobiol, 17, pp. 698-703
  • Marr, D., Simple memory: a theory for archicortex (1971) PhiloTransac R Soc B: Biol Sci, 26, pp. 23-81
  • Frankland, P.W., Bontempi, B., The organization of recent and remote memories (2005) Nat Rev Neurosci, 6, pp. 119-130
  • Squire, L.R., Bayley, P.J., The neuroscience of remote memory (2007) Curr Op Neurobiol, 17, pp. 185-196
  • Peigneux, P., Laureys, S., Fuchs, S., Destrebecqz, A., Collette, F., Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep (2003) Neuroimage, 20, pp. 125-134
  • Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Are spatial memories strengthened in the human hippocampus during slow wave sleep? (2004) Neuron, 44, pp. 535-545
  • Rasch, B., Büchel, C., Gais, S., Born, J., Odor cues during slow-wave sleep prompt declarative memory consolidation (2007) Science, 315, pp. 1426-1429
  • Diekelmann, S., Büchel, C., Born, J., Rasch, B., Labile or stable: opposing consequences for memory when reactivated during waking and sleep (2011) Nat Neurosci, 14 (3), pp. 381-386
  • Kudrimoti, H.S., Barnes, C.A., McNaughton, B.L., Reactivation of hippocampal cell assemblies: effects of behavioral state, experience, and EEG dynamics (1999) J Neurosci, 19, pp. 4090-4101
  • Hoffman, K.L., McNaughton, B.L., Coordinated reactivation of distributed memory traces in primate neocortex (2002) Science, 297, pp. 2070-2073
  • Peigneux, P., Orban, P., Balteau, E., Degueldre, C., Luxen, A., Offline persistence of memory-related cerebral activity during active wakefulness (2006) PLoS Biol, 4, pp. e100
  • Dudai, Y., Reconsolidation: the advantage of being refocused (2006) Curr Op Neurobiol, 16, pp. 174-178
  • Taubenfeld, S.M., Milekic, M.H., Monti, B., Alberini, C.M., The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta (2001) Nat Neurosci, 4, pp. 813-818
  • Kida, S., Josselyn, S.A., Peña de Ortiz, S., Kogan, J.H., Chevere, I., CREB required for the stability of new and reactivated fear memories (2002) Nat Neurosci, 5, pp. 348-355
  • Lee, J.L., Everitt, B.J., Thomas, K.L., Independent cellular processes for hippocampal memory consolidation and reconsolidation (2004) Science, 304, pp. 839-843
  • Tronson, N.C., Schrick, C., Fischer, A., Sananbenesi, F., Pagès, G., Regulatory mechanisms of fear extinction and depression-like behavior (2008) Neuropsychopharmacol, 33, pp. 1570-1583
  • Merlo, E., Romano, A., Memory extinction entails the inhibition of the transcription factor NF-kappaB (2008) PLoS One, 3, pp. e3687
  • Ben Mamou, C., Gamache, K., Nader, K., NMDA receptors are critical for unleashing consolidated auditory fear memories (2006) Nat Neurosci, 9, pp. 1237-1239
  • Alberini, C.M., Milekic, M.H., Tronel, S., Mechanisms of memory stabilization and de-stabilization (2006) Cell Mol Life Sci, 63, pp. 999-1008
  • Suzuki, A., Mukawa, T., Tsukagoshi, A., Frankland, P.W., Kida, S., Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories (2008) Learn Mem, 15, pp. 426-433
  • Lee, S.H., Choi, J.H., Lee, N., Lee, H.R., Kim, J.I., Synaptic protein degradation underlies destabilization of retrieved fear memory (2008) Science, 319, pp. 1253-1256
  • Nader, K., Einarsson, E.O., Memory reconsolidation: an update (2010) Ann N Y Acad Sci, 1191, pp. 27-41
  • Hardt, O., Einarsson, E.O., Nader, K., A bridge over troubled water: reconsolidation as a link between cognitive and neuroscientific memory research traditions (2010) Ann Rev Psychol, 61, pp. 141-167

Citas:

---------- APA ----------
Forcato, C., Rodríguez, M.L.C. & Pedreira, M.E. (2011) . Repeated labilization-reconsolidation processes strengthen declarative memory in humans. PLoS ONE, 6(8).
http://dx.doi.org/10.1371/journal.pone.0023305
---------- CHICAGO ----------
Forcato, C., Rodríguez, M.L.C., Pedreira, M.E. "Repeated labilization-reconsolidation processes strengthen declarative memory in humans" . PLoS ONE 6, no. 8 (2011).
http://dx.doi.org/10.1371/journal.pone.0023305
---------- MLA ----------
Forcato, C., Rodríguez, M.L.C., Pedreira, M.E. "Repeated labilization-reconsolidation processes strengthen declarative memory in humans" . PLoS ONE, vol. 6, no. 8, 2011.
http://dx.doi.org/10.1371/journal.pone.0023305
---------- VANCOUVER ----------
Forcato, C., Rodríguez, M.L.C., Pedreira, M.E. Repeated labilization-reconsolidation processes strengthen declarative memory in humans. PLoS ONE. 2011;6(8).
http://dx.doi.org/10.1371/journal.pone.0023305