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Abstract:

Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation.We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. © 2016 Forcato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Registro:

Documento: Artículo
Título:Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
Autor:Forcato, C.; Bavassi, L.; De Pino, G.; Fernández, R.S.; Villarreal, M.F.; Pedreira, M.E.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Instituto de Fisiología, Biología Molecular y Neurociencias-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, CONICET, Buenos Aires, Argentina
Centro Universitario de Imágenes Médicas, Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, Buenos Aires, Argentina
Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:comparative effectiveness; controlled study; functional magnetic resonance imaging; hippocampus; human; information retrieval; memory; adolescent; adult; association; female; hippocampus; learning; male; non-therapeutic research; nuclear magnetic resonance imaging; physiology; recall; reminder system; young adult; Adolescent; Adult; Association Learning; Cues; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory; Mental Recall; Nontherapeutic Human Experimentation; Reminder Systems; Young Adult
Año:2016
Volumen:11
Número:3
DOI: http://dx.doi.org/10.1371/journal.pone.0151381
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
CODEN:POLNC
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v11_n3_p_Forcato

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Citas:

---------- APA ----------
Forcato, C., Bavassi, L., De Pino, G., Fernández, R.S., Villarreal, M.F. & Pedreira, M.E. (2016) . Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process. PLoS ONE, 11(3).
http://dx.doi.org/10.1371/journal.pone.0151381
---------- CHICAGO ----------
Forcato, C., Bavassi, L., De Pino, G., Fernández, R.S., Villarreal, M.F., Pedreira, M.E. "Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process" . PLoS ONE 11, no. 3 (2016).
http://dx.doi.org/10.1371/journal.pone.0151381
---------- MLA ----------
Forcato, C., Bavassi, L., De Pino, G., Fernández, R.S., Villarreal, M.F., Pedreira, M.E. "Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process" . PLoS ONE, vol. 11, no. 3, 2016.
http://dx.doi.org/10.1371/journal.pone.0151381
---------- VANCOUVER ----------
Forcato, C., Bavassi, L., De Pino, G., Fernández, R.S., Villarreal, M.F., Pedreira, M.E. Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process. PLoS ONE. 2016;11(3).
http://dx.doi.org/10.1371/journal.pone.0151381