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Abstract:

Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism. © 2015 - IOS Press and the authors. All rights reserved.

Registro:

Documento: Artículo
Título:Role of TGF-β1 in the behavior disorders
Autor:Depino, A.M.
Filiación:Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:Autism; Depression-related behavior; Locomotion; Neurogenesis; Sociability; transforming growth factor beta1; autism; brain function; central nervous system function; circadian rhythm; corpus striatum; depression; hippocampus; human; locomotion; neuromodulation; nonhuman; priority journal; protein binding; protein expression; protein function; protein phosphorylation; Review; schizophrenia; signal transduction; socialization; substantia nigra
Año:2015
Volumen:6
Número:1
Página de inicio:19
Página de fin:23
DOI: http://dx.doi.org/10.3233/NIB-150105
Título revista:Advances in Neuroimmune Biology
Título revista abreviado:Adv. Neuroimmun. Biol.
ISSN:1878948X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1878948X_v6_n1_p19_Depino

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Citas:

---------- APA ----------
(2015) . Role of TGF-β1 in the behavior disorders. Advances in Neuroimmune Biology, 6(1), 19-23.
http://dx.doi.org/10.3233/NIB-150105
---------- CHICAGO ----------
Depino, A.M. "Role of TGF-β1 in the behavior disorders" . Advances in Neuroimmune Biology 6, no. 1 (2015) : 19-23.
http://dx.doi.org/10.3233/NIB-150105
---------- MLA ----------
Depino, A.M. "Role of TGF-β1 in the behavior disorders" . Advances in Neuroimmune Biology, vol. 6, no. 1, 2015, pp. 19-23.
http://dx.doi.org/10.3233/NIB-150105
---------- VANCOUVER ----------
Depino, A.M. Role of TGF-β1 in the behavior disorders. Adv. Neuroimmun. Biol. 2015;6(1):19-23.
http://dx.doi.org/10.3233/NIB-150105