Artículo

Dujardin, G.; Lafaille, C.; Petrillo, E.; Buggiano, V.; Gómez Acuña, L.I.; Fiszbein, A.; Godoy Herz, M.A.; Nieto Moreno, N.; Muñoz, M.J.; Alló, M.; Schor, I.E.; Kornblihtt, A.R. "Transcriptional elongation and alternative splicing" (2013) Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1829(1):134-140
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Abstract:

Alternative splicing has emerged as a key contributor to proteome diversity, highlighting the importance of understanding its regulation. In recent years it became apparent that splicing is predominantly cotranscriptional, allowing for crosstalk between these two nuclear processes. We discuss some of the links between transcription and splicing, with special emphasis on the role played by transcription elongation in the regulation of alternative splicing events and in particular the kinetic model of alternative splicing regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation. © 2012 Elsevier B.V.

Registro:

Documento: Artículo
Título:Transcriptional elongation and alternative splicing
Autor:Dujardin, G.; Lafaille, C.; Petrillo, E.; Buggiano, V.; Gómez Acuña, L.I.; Fiszbein, A.; Godoy Herz, M.A.; Nieto Moreno, N.; Muñoz, M.J.; Alló, M.; Schor, I.E.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, (C1428EHA) Buenos Aires, Argentina
Palabras clave:Alternative splicing; Pol II elongation; Transcription; alpha tropomyosin; caspase 9; DNA; dystrophin; fibronectin; histone deacetylase 1; histone deacetylase 2; histone H2A; histone H3; histone H4; MED23 protein; mediator complex; messenger RNA; protein bcl x; protein tyrosine kinase; RNA; RNA polymerase II; serine; small nuclear ribonucleoprotein; transactivator protein; unclassified drug; 3' untranslated region; 5' untranslated region; alternative RNA splicing; carboxy terminal sequence; chromatin assembly and disassembly; chromatin structure; exon; gene control; gene expression; genomic instability; histone methylation; human; in vitro study; in vivo study; intron; kinetics; nonhuman; nucleosome; priority journal; protein phosphorylation; protein synthesis; proteomics; reverse transcription polymerase chain reaction; review; RNA sequence; RNA synthesis; transcription elongation; transcription regulation; Xenopus; yeast; Alternative Splicing; Animals; Chromatin; Humans; Kinetics; Models, Biological; Protein Binding; RNA Polymerase II; Transcription Elongation, Genetic
Año:2013
Volumen:1829
Número:1
Página de inicio:134
Página de fin:140
DOI: http://dx.doi.org/10.1016/j.bbagrm.2012.08.005
Título revista:Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Título revista abreviado:Biochim. Biophys. Acta Gene Regul. Mech.
ISSN:18749399
CAS:DNA, 9007-49-2; RNA, 63231-63-0; caspase 9, 180189-96-2; dystrophin, 116978-02-0; fibronectin, 86088-83-7; protein tyrosine kinase, 80449-02-1; serine, 56-45-1, 6898-95-9; Chromatin; RNA Polymerase II, 2.7.7.-
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18749399_v1829_n1_p134_Dujardin

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Citas:

---------- APA ----------
Dujardin, G., Lafaille, C., Petrillo, E., Buggiano, V., Gómez Acuña, L.I., Fiszbein, A., Godoy Herz, M.A.,..., Kornblihtt, A.R. (2013) . Transcriptional elongation and alternative splicing. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1829(1), 134-140.
http://dx.doi.org/10.1016/j.bbagrm.2012.08.005
---------- CHICAGO ----------
Dujardin, G., Lafaille, C., Petrillo, E., Buggiano, V., Gómez Acuña, L.I., Fiszbein, A., et al. "Transcriptional elongation and alternative splicing" . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1829, no. 1 (2013) : 134-140.
http://dx.doi.org/10.1016/j.bbagrm.2012.08.005
---------- MLA ----------
Dujardin, G., Lafaille, C., Petrillo, E., Buggiano, V., Gómez Acuña, L.I., Fiszbein, A., et al. "Transcriptional elongation and alternative splicing" . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1829, no. 1, 2013, pp. 134-140.
http://dx.doi.org/10.1016/j.bbagrm.2012.08.005
---------- VANCOUVER ----------
Dujardin, G., Lafaille, C., Petrillo, E., Buggiano, V., Gómez Acuña, L.I., Fiszbein, A., et al. Transcriptional elongation and alternative splicing. Biochim. Biophys. Acta Gene Regul. Mech. 2013;1829(1):134-140.
http://dx.doi.org/10.1016/j.bbagrm.2012.08.005