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Oliveira, S.Q.D.; Almeida, M.T.R.D.; Maraslis, F.; Silva, I.T.; Sincero, T.C.M.; Palermo, J.A.; Cabrera, G.M.; Caro, M.S.B.; Simões, C.M.O.; Schenkel, E.P. "Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity" (2012) Phytochemistry Letters. 5(3):500-505
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Abstract:

Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1-3). The structures were established on the basis of their ESI-MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were evaluated for in vitro antiviral activity against Herpes Simplex Virus type 1 (HSV-1). The crude extract showed promising antiherpes activity expressed by a selectivity index of 6.2. © 2012 Phytochemical Society of Europe.

Registro:

Documento: Artículo
Título:Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
Autor:Oliveira, S.Q.D.; Almeida, M.T.R.D.; Maraslis, F.; Silva, I.T.; Sincero, T.C.M.; Palermo, J.A.; Cabrera, G.M.; Caro, M.S.B.; Simões, C.M.O.; Schenkel, E.P.
Filiación:Laboratório de Química Farmacêutica, Departamento de Ciências Farmacêuticas, Programa de Pós-Graduação em Farmácia, CEP 88.040-900, Florianópolis, SC, Brazil
Laboratório de Virologia Aplicada, Departamento de Ciências Farmacêuticas, Programa de Pós-Graduação em Farmácia, Florianópolis, Brazil
Departamento de Química, Programa de Pós-Graduação em Química, Universidade Federal de Santa Catarina, CEP 88.040-900, Florianópolis, SC, Brazil
UMYMFOR-Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria Pab.2, C1428EGA, Buenos Aires, Argentina
Palabras clave:Antiherpes; Diterpenes; Dodonaea viscosa; ent-Labdanes; HSV-1; Sapindaceae; 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol; antivirus agent; diterpene; ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide; ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide; plant extract; unclassified drug; antiviral activity; article; carbon nuclear magnetic resonance; Dodonaea viscosa; drug mechanism; drug structure; electrospray mass spectrometry; Herpes simplex virus 1; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; IC 50; infrared spectroscopy; nonhuman; nuclear Overhauser effect; priority journal; proton nuclear magnetic resonance; ultraviolet spectroscopy; Dodonaea viscosa; Human herpesvirus 1; Sapindaceae
Año:2012
Volumen:5
Número:3
Página de inicio:500
Página de fin:505
DOI: http://dx.doi.org/10.1016/j.phytol.2012.05.001
Título revista:Phytochemistry Letters
Título revista abreviado:Phytochem. Lett.
ISSN:18743900
CODEN:PLHEB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18743900_v5_n3_p500_Oliveira

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Citas:

---------- APA ----------
Oliveira, S.Q.D., Almeida, M.T.R.D., Maraslis, F., Silva, I.T., Sincero, T.C.M., Palermo, J.A., Cabrera, G.M.,..., Schenkel, E.P. (2012) . Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity. Phytochemistry Letters, 5(3), 500-505.
http://dx.doi.org/10.1016/j.phytol.2012.05.001
---------- CHICAGO ----------
Oliveira, S.Q.D., Almeida, M.T.R.D., Maraslis, F., Silva, I.T., Sincero, T.C.M., Palermo, J.A., et al. "Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity" . Phytochemistry Letters 5, no. 3 (2012) : 500-505.
http://dx.doi.org/10.1016/j.phytol.2012.05.001
---------- MLA ----------
Oliveira, S.Q.D., Almeida, M.T.R.D., Maraslis, F., Silva, I.T., Sincero, T.C.M., Palermo, J.A., et al. "Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity" . Phytochemistry Letters, vol. 5, no. 3, 2012, pp. 500-505.
http://dx.doi.org/10.1016/j.phytol.2012.05.001
---------- VANCOUVER ----------
Oliveira, S.Q.D., Almeida, M.T.R.D., Maraslis, F., Silva, I.T., Sincero, T.C.M., Palermo, J.A., et al. Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity. Phytochem. Lett. 2012;5(3):500-505.
http://dx.doi.org/10.1016/j.phytol.2012.05.001