Artículo
Sánchez, M.; Kramer, F.; Bargardi, S.; Palermo, J.A. "Melampolides from Argentinean Acanthospermum australe" (2009) Phytochemistry Letters. 2(3):93-95
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Abstract:
The investigation of the ethanol extract of Acanthospermum australe, collected in the province of Misiones, Argentina, yielded eight melampolides (1-8) of the acanthospermal type. Two of them, 8β-hydroxy-9α-(2-methylbutyryloxy)-14-oxo-acanthospermolide (3) and 9α-hydroxy-8β-(2-methylbutyryloxy)-14-oxo-acanthospermolide (7) are new compounds. Two other compounds (4 and 8) have been previously reported, and the NMR data of 4 are corrected. Compounds 1, 2, 5 and 6 have not been previously reported, but are probably artifacts formed during extraction. Compounds 3, 6 and 7 showed slight antibiotic activity against Gram-positive bacteria. © 2009 Phytochemical Society of Europe.
Registro:
| Documento: | Artículo |
| Título: | Melampolides from Argentinean Acanthospermum australe |
| Autor: | Sánchez, M.; Kramer, F.; Bargardi, S.; Palermo, J.A. |
| Filiación: | UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina Departamentos de Farmacia y Microbiología, Facultad de Ciencias Exactas, Químicas y Naturales, Univ. Nacional de Misiones, Av. Mariano Moreno 1375, 3300 Posadas, Misiones, Argentina |
| Palabras clave: | Acanthospermolides; Acanthospermum australe; Melampolides; Sesquiterpene lactones; 8beta hydroxy 9alpha (2 methylbutyryloxy) 14 oxo acanthospermolide; 9alpha hydroxy 8beta (2 methylbutyryloxy) 14 oxo acanthospermolide; acanthospermum australe extract; melampolide; plant extract; unclassified drug; Acanthospermum australe; antimicrobial activity; Argentina; article; artifact; drug isolation; drug structure; Gram positive bacterium; nuclear magnetic resonance; priority journal; shrub; Acanthospermum australe; Posibacteria |
| Año: | 2009 |
| Volumen: | 2 |
| Número: | 3 |
| Página de inicio: | 93 |
| Página de fin: | 95 |
| DOI: | http://dx.doi.org/10.1016/j.phytol.2008.12.007 |
| Título revista: | Phytochemistry Letters |
| Título revista abreviado: | Phytochem. Lett. |
| ISSN: | 18743900 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18743900_v2_n3_p93_Sanchez |
Referencias:
- Bohlmann, F., Jakupovic, J., Zdero, C., King, R.M., Robinson, H., Neue Melampolide und cis,cis-Germacranolide aus Vertretern der Subtribus Melampodiinae (1979) Phytochemistry, 18, pp. 625-630
- Bohlmann, F., Jakupovic, J., Dhar, A.K., King, R.M., Robinson, H., Two sesquiterpene and three diterpene lactones from Acanthospermum australe (1981) Phytochemistry, 20, pp. 1081-1083
- Bohlmann, F., Schmeda-Hirschmann, G., Jakupovic, J., New melampolides from Acanthospermum australe (1984) Planta Med., 50, pp. 37-39
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- Herz, W., Kalyanaraman, P.S., Acanthospermal A and Acanthospermal B, two new melampolides from Acanthospermum species (1975) J. Org. Chem., 40, pp. 3486-3491
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- Saleh, A.A., Cordell, G.A., Farnsworth, N.R., Potential anticancer agents. Part 13. Cytotoxic constituents of Acanthospermum glabratum (Asteraceae) (1980) J. Chem. Soc. Perkin Trans., 1 (5), pp. 1090-1097
- Seaman, F.C., Fischer, N.H., Stuessy, T.F., Systematic implications of sesquiterpene lactones in the subtribe melampodiinae (1980) Biochem. Syst. Ecol., 8, pp. 263-271
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Citas:
---------- APA ----------
Sánchez, M., Kramer, F., Bargardi, S. & Palermo, J.A. (2009) . Melampolides from Argentinean Acanthospermum australe. Phytochemistry Letters, 2(3), 93-95.http://dx.doi.org/10.1016/j.phytol.2008.12.007
---------- CHICAGO ----------
Sánchez, M., Kramer, F., Bargardi, S., Palermo, J.A. "Melampolides from Argentinean Acanthospermum australe" . Phytochemistry Letters 2, no. 3 (2009) : 93-95.http://dx.doi.org/10.1016/j.phytol.2008.12.007
---------- MLA ----------
Sánchez, M., Kramer, F., Bargardi, S., Palermo, J.A. "Melampolides from Argentinean Acanthospermum australe" . Phytochemistry Letters, vol. 2, no. 3, 2009, pp. 93-95.http://dx.doi.org/10.1016/j.phytol.2008.12.007
---------- VANCOUVER ----------
Sánchez, M., Kramer, F., Bargardi, S., Palermo, J.A. Melampolides from Argentinean Acanthospermum australe. Phytochem. Lett. 2009;2(3):93-95.http://dx.doi.org/10.1016/j.phytol.2008.12.007
