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Abstract:

Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Most of the drugs diminished cytosolic activity. Instead, isoflurane, enflurane and ethanol increased mitochondrial activity. NOS expression also depended on the drug tested. A comparative study was performed in liver. Our present and previous results indicate the widespread action of porphyrinogenic agents in brain, which could be the reason why it is difficult to establish the onset of acute porphyria neurological manifestations. © 2011 Bentham Science Publishers Ltd.

Registro:

Documento: Artículo
Título:Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
Autor:Lavandera, J.; Batlle, A.; Buzaleh, A.M.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina
Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina
Palabras clave:Anaesthetics; Brain; Nitric oxide synthase; Porphyric neuropathy; Porphyrinogenic agent; alcohol; allylisopropylacetamide; barbital; enflurane; griseofulvin; inducible nitric oxide synthase; isoflurane; neuronal nitric oxide synthase; nitric oxide synthase; porphyrinogen; animal experiment; animal tissue; article; brain function; cell fractionation; comparative study; controlled study; enzyme activity; liver metabolism; male; mouse; nonhuman; outcome assessment; priority journal; protein expression; single drug dose; starvation; Western blotting; Anesthetics; Animals; Brain; Cell Fractionation; Cytosol; Enzyme Induction; Liver; Male; Mice; Mitochondria; Nitric Oxide Synthase; Porphyrias; Mus
Año:2011
Volumen:5
Número:1
Página de inicio:25
Página de fin:29
DOI: http://dx.doi.org/10.2174/187231211794455271
Título revista:Drug Metabolism Letters
Título revista abreviado:Drug Metab. Lett.
ISSN:18723128
CAS:alcohol, 64-17-5; allylisopropylacetamide, 299-78-5; barbital, 144-02-5, 57-44-3; enflurane, 13838-16-9; griseofulvin, 126-07-8; inducible nitric oxide synthase, 501433-35-8; isoflurane, 26675-46-7; neuronal nitric oxide synthase, 506430-87-1; nitric oxide synthase, 125978-95-2; porphyrinogen, 4396-11-6; Anesthetics; Nitric Oxide Synthase, 1.14.13.39
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18723128_v5_n1_p25_Lavandera

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Citas:

---------- APA ----------
Lavandera, J., Batlle, A. & Buzaleh, A.M. (2011) . Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs. Drug Metabolism Letters, 5(1), 25-29.
http://dx.doi.org/10.2174/187231211794455271
---------- CHICAGO ----------
Lavandera, J., Batlle, A., Buzaleh, A.M. "Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs" . Drug Metabolism Letters 5, no. 1 (2011) : 25-29.
http://dx.doi.org/10.2174/187231211794455271
---------- MLA ----------
Lavandera, J., Batlle, A., Buzaleh, A.M. "Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs" . Drug Metabolism Letters, vol. 5, no. 1, 2011, pp. 25-29.
http://dx.doi.org/10.2174/187231211794455271
---------- VANCOUVER ----------
Lavandera, J., Batlle, A., Buzaleh, A.M. Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs. Drug Metab. Lett. 2011;5(1):25-29.
http://dx.doi.org/10.2174/187231211794455271