Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes India.
Documento: | Artículo |
Título: | Adiponectin and waist circumference as predictors of insulin-resistance in women |
Autor: | Bonneau, G.A.; Pedrozo, W.R.; Berg, G. |
Filiación: | Ministerio de Salud Pública de la Provincia de Misiones, Argentina Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones, Argentina Lipids and Lipoproteins Laboratory, Faculty of Pharmacy and Biochemistry, INFIBIOC, University of Buenos Aires, Argentina |
Idioma: | Inglés |
Palabras clave: | Abdominal obesity; Adiponectin; Female gender; Insulin-resistance; Post-menopause |
Año: | 2013 |
DOI: | http://dx.doi.org/10.1016/j.dsx.2013.10.005 |
Título revista: | Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Título revista abreviado: | Diabetes Metab. Syndr. Clin. Res. Rev. |
ISSN: | 18714021 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18714021_v_n_p_Bonneau |