Artículo

Bonneau, G.A.; Pedrozo, W.R.; Berg, G. "Adiponectin and waist circumference as predictors of insulin-resistance in women" (2014) Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 8(1):3-7
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Abstract:

Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes. Published by Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Adiponectin and waist circumference as predictors of insulin-resistance in women
Autor:Bonneau, G.A.; Pedrozo, W.R.; Berg, G.
Filiación:Ministerio de Salud Pública de la Provincia de Misiones, Argentina
Facultad de Ciencias Exactas, Químicas Y Naturales, Universidad Nacional de Misiones, Argentina
Lipids and Lipoproteins Laboratory, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Palabras clave:Abdominal obesity; Adiponectin; Female gender; Insulin-resistance; Post-menopause; adiponectin; antihypertensive agent; C reactive protein; glucose; high density lipoprotein cholesterol; insulin; triacylglycerol; adult; aged; article; blood pressure; body mass; cardiovascular risk; cholesterol blood level; diastolic blood pressure; female; glucose blood level; human; hypertension; insulin blood level; insulin resistance; major clinical study; male; middle aged; obesity; postmenopause; premenopause; priority journal; protein blood level; systolic blood pressure; triacylglycerol blood level; waist circumference; Abdominal obesity; Adiponectin; Female gender; Insulin-resistance; Post-menopause; Adiponectin; Adult; Age Factors; Aged; Argentina; Biological Markers; Blood Glucose; Blood Pressure; C-Reactive Protein; Cholesterol; Female; Humans; Insulin; Insulin Resistance; Luminescent Measurements; Male; Middle Aged; Prevalence; Risk Factors; Statistics, Nonparametric; Waist Circumference
Año:2014
Volumen:8
Número:1
Página de inicio:3
Página de fin:7
DOI: http://dx.doi.org/10.1016/j.dsx.2013.10.005
Título revista:Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Título revista abreviado:Diabetes Metab. Syndr. Clin. Res. Rev.
ISSN:18714021
CAS:adiponectin, 283182-39-8; C reactive protein, 9007-41-4; glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18714021_v8_n1_p3_Bonneau

Referencias:

  • Alwan, A., (2011) Global Status Report on Non Communicable Diseases 2010, , World Health Organization. Geneva: World Health Organization
  • Libby, P., Inflammation in atherosclerosis (2012) Arterioscler Thromb Vasc Biol, 32, pp. 2045-2051
  • (2008) Global Strategy on Diet, Physical Activity and Health, , http://www.who.int/dietphysicalactivity/publications/facts/obesity/en/[, World Health Organization; accessed 15.05.08
  • Nieves, D.J., Cnop, M., Retzlaff, B., Walden, C.E., Brunzell, J.D., Knopp, R.H., Kahn, S.E., The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat (2003) Diabetes, 52 (1), pp. 172-179. , DOI 10.2337/diabetes.52.1.172
  • Abate, N., Garg, A., Heterogeneity in adipose tissue metabolism: Causes, implications and management of regional adiposity (1995) Prog Lipid Res, 34, pp. 53-70
  • Frayn, K.N., Subcutaneous and visceral adipose tissue their relation to metabolic syndrome (2000) Endocr Rev, 21, pp. 697-738
  • Neeland, I.J., Turer, A.T., Ayers, C.R., Powell-Wiley, T.M., Vega, G.L., Farzaneh-Far, R., Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults (2012) J Am Med Assoc, 308, pp. 1150-1159
  • Reaven, G.M., The insulin resistance syndrome (2003) Current Atherosclerosis Reports, 5 (5), pp. 364-371
  • Despres, J.-P., Couillard, C., Gagnon, J., Bergeron, J., Leon, A.S., Rao, D.C., Skinner, J.S., Bouchard, C., Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: The health, risk factors, exercise training, and genetics (HERITAGE) family study (2000) Arteriosclerosis, Thrombosis, and Vascular Biology, 20 (8), pp. 1932-1938
  • Berg, G., Mesch, V., Boero, L., Sayegh, F., Prada, M., Royer, M., Muzzio, M.L., Benencia, H., Lipid and lipoprotein profile in menopausal transition. Effects of hormones, age and fat distribution (2004) Hormone and Metabolic Research, 36 (4), pp. 215-220. , DOI 10.1055/s-2004-814450
  • Mesch, V.R., Boero, L.E., Siseles, N.O., Royer, M., Prada, M., Sayegh, F., Schreier, L., Berg, G.A., Metabolic syndrome throughout the menopausal transition: Influence of age and menopausal status (2006) Climacteric, 9 (1), pp. 40-48. , DOI 10.1080/13697130500487331, PII X605V246J6658P14
  • Ohash, K., Ouchi, N., Matsuzawa, Y., Anti-inflammatory and anti-atherogenic properties of adiponectina (2012) Biochimie, 94, pp. 2137-2142
  • Shibata, R., Ouchi, N., Murohara, T., Adiponectin cardiovascular disease (2009) Circ J, 73, pp. 608-614
  • Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R.E., Tataranni, P.A., Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia (2001) Journal of Clinical Endocrinology and Metabolism, 86 (5), pp. 1930-1935. , DOI 10.1210/jc.86.5.1930
  • Wolfson, N., Gavish, D., Matas, Z., Boaz, M., Shargorodsky, M., Relation of adiponectin to glucose tolerance status, adiposity, and cardiovascular risk factor load (2012) Exp Diabet Res, pp. 1-5
  • Lilja, M., Rolandsson, O., Norberg, M., Söderberg, S., The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance (2012) Metab Syndr Relat Disord, 10, pp. 143-151
  • Hao, G., Li, W., Guo, R., Yang, J.G., Wang, Y., Tian, Y., Serum total adiponectin level and the risk of cardiovascular disease in general population: A meta-analysis of 17 prospective studies (2013) Atherosclerosis, 228, pp. 29-35
  • Sattar, N., Wannamethee, G., Sarwar, N., Tchernova, J., Cherry, L., Wallace, A.M., Danesh, J., Whincup, P.H., Adiponectin and coronary heart disease: A prospective study and meta-analysis (2006) Circulation, 114 (7), pp. 623-629. , DOI 10.1161/CIRCULATIONAHA.106.618918, PII 0000301720060815000005
  • Lim, S., Koo, B.K., Cho, S.W., Tchernova, J., Cherry, L., Wallace, A.M., Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: The Korean atherosclerosis study (KAS): A 42-month prospective study (2008) Atherosclerosis, 196, pp. 398-404
  • Lindberg, S., Mogelvang, R., Pedersen, S.H., Bjerre, M., Frystyk, J., Flyvbjerg, A., Relation of serum adiponectin levels to number of traditional atherosclerotic risk factors and all-cause mortality and major adverse cardiovascular events (from the Copenhagen City Heart Study) (2013) Am J Cardiol
  • Matsubara, M., Namioka, K., Katayose, S., Decreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevation (2003) European Journal of Endocrinology, 148 (6), pp. 657-662. , DOI 10.1530/eje.0.1480657
  • Bonneau, G.A., Castillo Rascón, M.S., Pedrozo, W.R., Ceballos, B., Leiva, R., Blanco, N., Presencia de insulinorresistencia en Síndrome metabólico (2006) Rev Argent Endocrinol Metab, 43, pp. 215-223
  • Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Final Report (2002) Circulation, 106, pp. 3143-3421
  • Physical status: The use and interpretation of anthropometry. Report of a WHO Expert Committee (1995) WHO Technical Report Series 854, , WHO. Geneva: World Health Organization
  • Pickering, T.G., Hall, J.E., Appel, L.J., Falkner, B.E., Graves, J., Hill, M.N., Jones, D.W., Roccella, E.J., Recommendations for blood pressure measurement in humans and experimental animals. Part 1: Blood pressure measurement in humans: A statement for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research (2005) Hypertension, 45 (1), pp. 142-161. , DOI 10.1161/01.HYP.0000150859.47929.8e
  • McLaughlin, T., Reaven, G., Abbasi, F., Lamendola, C., Saad, M., Waters, D., Simon, J., Krauss, R.M., Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease? (2005) American Journal of Cardiology, 96 (3), pp. 399-404. , DOI 10.1016/j.amjcard.2005.03.085, PII S0002914905007411
  • Matthews, D.R., Hosker, J.P., Rudenski, A.S., Homeostasis model assessment: Insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man (1985) Diabetologia, 28 (7), pp. 412-419. , DOI 10.1007/BF00280883
  • Coniglio, R., Pino, M., Cailotto, M., Colombo, O., Selles, J., Framarini, S., Índice de insulinorresistencia y síndrome metabólico en un grupo poblacional del sur argentino (2000) Revista Argentina de Cardiología, 68 (5), pp. 671-681
  • Santi, M.J., Carrozas, M.A., Barba, A., Astola, A., Jimenez, A., Mangas, A., Waist circumference as a predictor of insulin resistance in young men (2005) Medicina Clinica, 125 (2), pp. 46-50. , DOI 10.1157/13076462, 77.353
  • Ascaso, J.F., Romero, P., Real, J., Lorente, R., Martinez Valls, J., Carmena, R., Obesidad abdominal, resistencia a la insulina y síndrome metabólico en una población del sur de Europa (2003) Eur J Med, 14, pp. 101-106
  • Hocking, S., Samocha-Bonet, D., Milner, K.L., Greenfield, J.R., Chisholm, D.J., Adiposity and insulin resistance in humans: The role of the different tissue and cellular lipid depots (2013) Endocr Rev
  • Cook, J.R., Semple, R.K., Hypoadiponectinemia-cause or consequence of human "insulin resistance"? (2010) J Clin Endocrinol Metab, 95, pp. 1554-1654
  • Hivert, M.F., Sullivan, L.M., Shrader, P., Fox, C.S., Nathan, D.M., D'Agostino, R.B., Insulin resistance influences the association of adiponectin levels with diabetes incidence in two population-based cohorts: The Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 study and the Framingham Offspring Study (2011) Diabetologia, 54, pp. 1019-1024
  • Turer, A.T., Scherer, P.E., Adiponectin: Mechanistic insights and clinical implications (2012) Diabetologia, 55, pp. 2319-2326
  • Ridker, P.M., C-reactive protein. A simple test to help predict risk of heart attack and stroke (2003) Circulation, 108, pp. 81-85
  • Kassi, E., Dalamaga, M., Hroussalas, G., Kazanis, K., Merantzi, G., Zachari, A., Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT (2010) Maturitas, 67, pp. 72-77
  • Matsushita, Y., Nakagawa, T., Yamamoto, S., Kato, T., Ouchi, T., Kikuchi, N., Adiponectin and visceral fat associate with cardiovascular risk factors (2013) Obesity (Silver Spring)
  • Rathmann, W., Haastert, B., Herder, C., Hauner, H., Koenig, W., Meisinger, C., Holle, R., Giani, G., Differential association of adiponectin with cardiovascular risk markers in men and women? The KORA survey 2000 (2007) International Journal of Obesity, 31 (5), pp. 770-776. , DOI 10.1038/sj.ijo.0803471, PII 0803471
  • Matsui, S., Yasui, T., Tani, A., Kato, T., Kunimi, K., Uemura, H., Association of circulating adiponectin with testosterone in women during the menopausal transition (2012) Maturitas, 73, pp. 255-260
  • Sieminska, L., Wojciechowska, C., Niedziolka, D., Marek, B., Kos-Kudla, B., Kajdaniuk, D., Nowak, M., Effect of postmenopause and hormone replacement therapy on serum adiponectin levels (2005) Metabolism: Clinical and Experimental, 54 (12), pp. 1610-1614. , DOI 10.1016/j.metabol.2005.06.008, PII S002604950500257X
  • Laughlin, G.A., Barrett-Connor, E., May, S., Sex-specific determinants of serum adiponectin in older adults: The role of endogenous sex hormones (2007) Int J Obes, 31, pp. 457-465

Citas:

---------- APA ----------
Bonneau, G.A., Pedrozo, W.R. & Berg, G. (2014) . Adiponectin and waist circumference as predictors of insulin-resistance in women. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 8(1), 3-7.
http://dx.doi.org/10.1016/j.dsx.2013.10.005
---------- CHICAGO ----------
Bonneau, G.A., Pedrozo, W.R., Berg, G. "Adiponectin and waist circumference as predictors of insulin-resistance in women" . Diabetes and Metabolic Syndrome: Clinical Research and Reviews 8, no. 1 (2014) : 3-7.
http://dx.doi.org/10.1016/j.dsx.2013.10.005
---------- MLA ----------
Bonneau, G.A., Pedrozo, W.R., Berg, G. "Adiponectin and waist circumference as predictors of insulin-resistance in women" . Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 8, no. 1, 2014, pp. 3-7.
http://dx.doi.org/10.1016/j.dsx.2013.10.005
---------- VANCOUVER ----------
Bonneau, G.A., Pedrozo, W.R., Berg, G. Adiponectin and waist circumference as predictors of insulin-resistance in women. Diabetes Metab. Syndr. Clin. Res. Rev. 2014;8(1):3-7.
http://dx.doi.org/10.1016/j.dsx.2013.10.005