Artículo

Barttfeld, P.; Amoruso, L.; Ais, J.; Cukier, S.; Bavassi, L.; Tomio, A.; Manes, F.; Ibanez, A.; Sigman, M. "Organization of brain networks governed by long-range connections index autistic traits in the general population" (2013) Journal of Neurodevelopmental Disorders. 5(1)
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Abstract:

Background: The dimensional approach to autism spectrum disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We explored the potential utility of electroencephalography (EEG) functional connectivity as a biomarker. We hypothesized that individual differences in autistic traits of typical subjects would involve a long-range connectivity diminution within the delta band. Methods: Resting-state EEG functional connectivity was measured for 74 neurotypical subjects. All participants also provided a questionnaire (Social Responsiveness Scale, SRS) that was completed by an informant who knows the participant in social settings. We conducted multivariate regression between the SRS score and functional connectivity in all EEG frequency bands. We explored modulations of network graph metrics characterizing the optimality of a network using the SRS score. Results: Our results show a decay in functional connectivity mainly within the delta and theta bands (the lower part of the EEG spectrum) associated with an increasing number of autistic traits. When inspecting the impact of autistic traits on the global organization of the functional network, we found that the optimal properties of the network are inversely related to the number of autistic traits, suggesting that the autistic dimension, throughout the entire population, modulates the efficiency of functional brain networks. Conclusions: EEG functional connectivity at low frequencies and its associated network properties may be associated with some autistic traits in the general population. © 2013 Barttfeld et al.; licensee BioMed Central Ltd.

Registro:

Documento: Artículo
Título:Organization of brain networks governed by long-range connections index autistic traits in the general population
Autor:Barttfeld, P.; Amoruso, L.; Ais, J.; Cukier, S.; Bavassi, L.; Tomio, A.; Manes, F.; Ibanez, A.; Sigman, M.
Filiación:Physics Department, Laboratory of Integrative Neuroscience, FCEyN, UBA, IFIBA, Ciudad Universitaria, Conicet, Pabellón 1, Buenos Aires, 1428, Argentina
Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale (INSERM), Gif sur Yvette, 91191, France
Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina
Programa Argentino para Niños, Adolescentes y Adultos con Condiciones del Espectro Autista (PANAACEA), Buenos Aires, Argentina
UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile
Universidad Torcuato Di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires, C1428BIJ, Argentina
Palabras clave:Autism spectrum disorders; Autistic traits; Electroencephalography; Long-range connections; Small world; Synchronization likelihood; adult; alpha rhythm; Article; autism; beta rhythm; corpus callosum; data analysis software; delta rhythm; electroencephalography; female; functional connectivity; gamma rhythm; human; male; priority journal; resting state network; sleep spindle; social adaptation; theta rhythm
Año:2013
Volumen:5
Número:1
DOI: http://dx.doi.org/10.1186/1866-1955-5-16
Título revista:Journal of Neurodevelopmental Disorders
Título revista abreviado:J. Neurodevelopmental Disord.
ISSN:18661947
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18661947_v5_n1_p_Barttfeld

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Citas:

---------- APA ----------
Barttfeld, P., Amoruso, L., Ais, J., Cukier, S., Bavassi, L., Tomio, A., Manes, F.,..., Sigman, M. (2013) . Organization of brain networks governed by long-range connections index autistic traits in the general population. Journal of Neurodevelopmental Disorders, 5(1).
http://dx.doi.org/10.1186/1866-1955-5-16
---------- CHICAGO ----------
Barttfeld, P., Amoruso, L., Ais, J., Cukier, S., Bavassi, L., Tomio, A., et al. "Organization of brain networks governed by long-range connections index autistic traits in the general population" . Journal of Neurodevelopmental Disorders 5, no. 1 (2013).
http://dx.doi.org/10.1186/1866-1955-5-16
---------- MLA ----------
Barttfeld, P., Amoruso, L., Ais, J., Cukier, S., Bavassi, L., Tomio, A., et al. "Organization of brain networks governed by long-range connections index autistic traits in the general population" . Journal of Neurodevelopmental Disorders, vol. 5, no. 1, 2013.
http://dx.doi.org/10.1186/1866-1955-5-16
---------- VANCOUVER ----------
Barttfeld, P., Amoruso, L., Ais, J., Cukier, S., Bavassi, L., Tomio, A., et al. Organization of brain networks governed by long-range connections index autistic traits in the general population. J. Neurodevelopmental Disord. 2013;5(1).
http://dx.doi.org/10.1186/1866-1955-5-16