Abstract:
Summary: The complex dynamics of Trypanosoma cruzi infection (Chagas disease) involves different actors and multiple transmission routes. Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathematical deterministic model was formulated considering: (i) the three clinical forms in humans: acute, chronic indeterminate and chronic with determinate pathology, (ii) the three main modes of transmission in the human population: vector-borne, congenital and transfusional, (iii) populations of triatomines and dogs as the main domestic reservoirs of T. cruzi and (iv) open populations. A numerical simulation was also performed to estimate the initial spread of the infection in a typical rural household in the endemic zone of the Argentine Gran Chaco. We also analysed the incidence of infected individuals corresponding to each of the three species (humans/triatomines/dogs) over times until the appearance of the first case in the other species. The model predicts that, in the absence of control measures, a few infected individuals are sufficient for the establishment and dispersion of the infection in all the inhabitants of the household. The model proposed and the results obtained allow describing the consequences of the presence of infected individuals in any of the three species considered in the dynamics and the output of the infection. © 2014 Blackwell Verlag GmbH.
Registro:
Documento: |
Artículo
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Título: | Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
Autor: | Fabrizio, M.C.; Schweigmann, N.J.; Bartoloni, N.J. |
Filiación: | Departamento de Métodos Cuantitativos y Sistemas de Información, Facultad de Agronomía, Universidad de Buenos Aires, Buenos Aires, Argentina Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | Dogs; Household infection; Mathematical model; Triatomines; Trypanosoma cruzi infection; Argentina; Article; birth rate; disease model; disease transmission; feeding behavior; fertility; household; human; mathematical analysis; mathematical model; nonhuman; prediction; seroprevalence; simulation; trypanosomiasis; validation process; animal; Chagas disease; computer simulation; disease carrier; dog; Dog Diseases; incidence; parasitology; physiology; rural population; theoretical model; transmission; Triatominae; Trypanosoma cruzi; zoonosis; Canis familiaris; Trypanosoma cruzi; Animals; Argentina; Chagas Disease; Computer Simulation; Dog Diseases; Dogs; Humans; Incidence; Insect Vectors; Models, Theoretical; Rural Population; Triatominae; Trypanosoma cruzi; Zoonoses |
Año: | 2014
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Volumen: | 61
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Número: | 8
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Página de inicio: | 545
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Página de fin: | 559
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DOI: |
http://dx.doi.org/10.1111/zph.12104 |
Título revista: | Zoonoses and Public Health
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Título revista abreviado: | Zoonoses Public Health
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ISSN: | 18631959
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18631959_v61_n8_p545_Fabrizio |
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Citas:
---------- APA ----------
Fabrizio, M.C., Schweigmann, N.J. & Bartoloni, N.J.
(2014)
. Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco. Zoonoses and Public Health, 61(8), 545-559.
http://dx.doi.org/10.1111/zph.12104---------- CHICAGO ----------
Fabrizio, M.C., Schweigmann, N.J., Bartoloni, N.J.
"Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco"
. Zoonoses and Public Health 61, no. 8
(2014) : 545-559.
http://dx.doi.org/10.1111/zph.12104---------- MLA ----------
Fabrizio, M.C., Schweigmann, N.J., Bartoloni, N.J.
"Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco"
. Zoonoses and Public Health, vol. 61, no. 8, 2014, pp. 545-559.
http://dx.doi.org/10.1111/zph.12104---------- VANCOUVER ----------
Fabrizio, M.C., Schweigmann, N.J., Bartoloni, N.J. Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco. Zoonoses Public Health. 2014;61(8):545-559.
http://dx.doi.org/10.1111/zph.12104