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Abstract:

Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Registro:

Documento: Artículo
Título:Involvement of cellular proteins in Junin arenavirus entry
Autor:Martinez, M.G.; Forlenza, M.B.; Candurra, N.A.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Universidad de Buenos Aires, Pabellón II, Piso 4, 1428 Buenos Aires, Argentina
Palabras clave:Arenavirus; Endocytosis; Junin virus; Actin cytoskeleton; Arenavirus; Cellular proteins; Clathrin; Dynamin; Endocytic pathways; Endocytosis; Human pathogens; Junin virus; Late endosomes; Microtubules; PH-dependent; Vero cells; cell protein; chlorpromazine; dynamin II; epidermal growth factor receptor pathway substrate 15; Rab protein; Rab7 protein; virus nucleoprotein; animal cell; article; controlled study; embryo; endocytosis; endosome; genetic transfection; human; human cell; immunofluorescence test; Junin virus; mouse; nonhuman; priority journal; protein analysis; protein function; signal transduction; Vero cell; virus cell interaction; virus entry; virus replication; Animals; Calcium-Binding Proteins; Cercopithecus aethiops; Dynamin II; Endocytosis; Humans; Intracellular Signaling Peptides and Proteins; Junin virus; Mice; Phosphoproteins; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; Vero Cells; Viral Load; Viral Proteins; Virus Internalization; Arenavirus; Junin virus
Año:2009
Volumen:4
Número:6
Página de inicio:866
Página de fin:870
DOI: http://dx.doi.org/10.1002/biot.200800357
Título revista:Biotechnology Journal
Título revista abreviado:Biotechnol. J.
ISSN:18606768
CAS:Rab7 protein, 185229-47-4; chlorpromazine, 50-53-3, 69-09-0; Calcium-Binding Proteins; Dynamin II, 3.6.1.50; Intracellular Signaling Peptides and Proteins; Phosphoproteins; Viral Proteins; rab GTP-Binding Proteins, 3.6.1.-; rab5 GTP-Binding Proteins, 3.6.5.2; rab7 protein, 152989-05-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18606768_v4_n6_p866_Martinez

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Citas:

---------- APA ----------
Martinez, M.G., Forlenza, M.B. & Candurra, N.A. (2009) . Involvement of cellular proteins in Junin arenavirus entry. Biotechnology Journal, 4(6), 866-870.
http://dx.doi.org/10.1002/biot.200800357
---------- CHICAGO ----------
Martinez, M.G., Forlenza, M.B., Candurra, N.A. "Involvement of cellular proteins in Junin arenavirus entry" . Biotechnology Journal 4, no. 6 (2009) : 866-870.
http://dx.doi.org/10.1002/biot.200800357
---------- MLA ----------
Martinez, M.G., Forlenza, M.B., Candurra, N.A. "Involvement of cellular proteins in Junin arenavirus entry" . Biotechnology Journal, vol. 4, no. 6, 2009, pp. 866-870.
http://dx.doi.org/10.1002/biot.200800357
---------- VANCOUVER ----------
Martinez, M.G., Forlenza, M.B., Candurra, N.A. Involvement of cellular proteins in Junin arenavirus entry. Biotechnol. J. 2009;4(6):866-870.
http://dx.doi.org/10.1002/biot.200800357