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Abstract:

Pulmonary arterial hypertension (PAH) is a consequence of acute or chronic disorder of the pulmonary vasculature, which is characterized by increased pulmonary artery pressure as a result of increased pulmonary vascular resistance. The pathophysiology of PAH is characterized by pulmonary vascular vasoconstriction, smooth muscle cell proliferation, and thrombosis. These changes are a result of an imbalance between vasodilators (prostacyclin, nitric oxide, vasoactive intestinal peptide) and vasoconstrictors (thromboxane A2, endothelin, serotonin), growth inhibitors and mitogenic factors, and antithrombotic and prothrombotic factors. Recent advances in treatment are directed at restoring the balance between these systems. Endothelin receptor antagonists (bosentan, ambrisentan), phosphodiesterase type 5 inhibitors (sildenafil, tadalafil), and prostacylin (epoprostenol, iloprost, treprostinil, beraprost) represent the different classes of medications that are currently used in monotherapy and in combination to treat PAH. The purpose of this review is to provide the reader with an update on the treatment of PAH with antagonists of endothelin receptors. © 2013 Silver Horse.

Registro:

Documento: Artículo
Título:Endothelin receptor antagonists for pulmonary arterial hypertension
Autor:Bevacqua, R.J.; Bortman, G.; Perrone, S.V.
Filiación:División Cardiología, Pabellón Inchauspe, Hospital General de Agudos 'Dr. José María Ramos Mejía', GCBA, Ciudad de Buenos Aires, Argentina
Insuficiencia cardíaca, Hipertensión pulmonar, Trasplante cardíaco, Sanatorio de la Trinidad-Mitre, Ciudad de Buenos Aires, Argentina
Insuficiencia cardíaca, Hipertensión pulmonar, Trasplante cardíaco, Instituto FLENI, Ciudad de Buenos Aires, Argentina
Hospital de Alta Complejidad 'Pte. Juan Domingo Perón', Formosa, Formosa, Argentina
Instituto Argentino de Diagnóstico y Tratamiento, Ciudad de Buenos Aires, Argentina
Hospital Alta Complejidad en Red El Cruce 'Dr. Néstor Carlos Kirchner', Florencio Varela, Buenos Aires, Argentina
Instituto Cardiovascular Lezica, San Isidro, Buenos Aires, Argentina
Hospital Italiano de Mendoza, Mendoza, Argentina
Palabras clave:Ambrisentan; Bosentan; Combination therapy; Endothelin receptor antagonist; Pathophysiological pathways; Pulmonary arterial hypertension
Año:2013
Volumen:8
Número:2
Página de inicio:77
Página de fin:94
Título revista:Insuficiencia Cardiaca
Título revista abreviado:Insuficiencia Cardiaca
ISSN:18501044
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18501044_v8_n2_p77_Bevacqua

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Citas:

---------- APA ----------
Bevacqua, R.J., Bortman, G. & Perrone, S.V. (2013) . Endothelin receptor antagonists for pulmonary arterial hypertension . Insuficiencia Cardiaca, 8(2), 77-94.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18501044_v8_n2_p77_Bevacqua [ ]
---------- CHICAGO ----------
Bevacqua, R.J., Bortman, G., Perrone, S.V. "Endothelin receptor antagonists for pulmonary arterial hypertension " . Insuficiencia Cardiaca 8, no. 2 (2013) : 77-94.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18501044_v8_n2_p77_Bevacqua [ ]
---------- MLA ----------
Bevacqua, R.J., Bortman, G., Perrone, S.V. "Endothelin receptor antagonists for pulmonary arterial hypertension " . Insuficiencia Cardiaca, vol. 8, no. 2, 2013, pp. 77-94.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18501044_v8_n2_p77_Bevacqua [ ]
---------- VANCOUVER ----------
Bevacqua, R.J., Bortman, G., Perrone, S.V. Endothelin receptor antagonists for pulmonary arterial hypertension . Insuficiencia Cardiaca. 2013;8(2):77-94.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18501044_v8_n2_p77_Bevacqua [ ]