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Radusky, L.; Defelipe, L.A.; Lanzarotti, E.; Luque, J.; Barril, X.; Marti, M.A.; Turjanski, A.G. "TuberQ: A Mycobacterium tuberculosis protein druggability database" (2014) Database. 2014
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Abstract:

In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320 000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multi-drug-resistant strains of Mycobacterium tuberculosis (Mtb), the negative drug-drug interactions with certain HIV (or other disease) treatments and the ineffectiveness against dormant Mtb. In this context we present here the TuberQ database, a novel resource for all researchers working in the field of drug development in TB. The main feature of TuberQ is to provide a druggability analysis of Mtb proteins in a consistent and effective manner, contributing to a better selection of potential drug targets for screening campaigns and the analysis of targets for structure-based drug design projects. The structural druggability analysis is combined with features related to the characteristics of putative inhibitor binding pockets and with functional and biological data of proteins. The structural analysis is performed on all available unique Mtb structures and high-quality structural homology-based models. This information is shown in an interactive manner, depicting the protein structure, the pockets and the associated characteristics for each protein. TuberQ also provides information about gene essentiality information, as determined from whole cell-based knockout experiments, and expression information obtained from microarray experiments done in different stress-related conditions. We hope that TuberQ will be a powerful tool for researchers working in TB and eventually will lead to the identification of novel putative targets and progresses in therapeutic activities. © The Author(s) 2014.

Registro:

Documento: Artículo
Título:TuberQ: A Mycobacterium tuberculosis protein druggability database
Autor:Radusky, L.; Defelipe, L.A.; Lanzarotti, E.; Luque, J.; Barril, X.; Marti, M.A.; Turjanski, A.G.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Buenos Aires, C1428EHA, Argentina
INQUIMAE/UBA-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Buenos Aires, C1428EHA, Argentina
Department of Physical Chemistry, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Campus de l'Alimentació Torribera, Avgda. Prat de la Riba 171, Santa Coloma de Gramenet, 08921, Spain
Department of Physical Chemistry, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Avgda. Diagonal 643, Barcelona, 08028, Spain
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, Barcelona, 08010, Spain
Palabras clave:bacterial protein; tuberculostatic agent; article; chemistry; data base; Internet; metabolism; Mycobacterium tuberculosis; protein database; protein tertiary structure; Antitubercular Agents; Bacterial Proteins; Database Management Systems; Databases, Protein; Internet; Mycobacterium tuberculosis; Protein Structure, Tertiary
Año:2014
Volumen:2014
DOI: http://dx.doi.org/10.1093/database/bau035
Título revista:Database
Título revista abreviado:Database
ISSN:17580463
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17580463_v2014_n_p_Radusky

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Citas:

---------- APA ----------
Radusky, L., Defelipe, L.A., Lanzarotti, E., Luque, J., Barril, X., Marti, M.A. & Turjanski, A.G. (2014) . TuberQ: A Mycobacterium tuberculosis protein druggability database. Database, 2014.
http://dx.doi.org/10.1093/database/bau035
---------- CHICAGO ----------
Radusky, L., Defelipe, L.A., Lanzarotti, E., Luque, J., Barril, X., Marti, M.A., et al. "TuberQ: A Mycobacterium tuberculosis protein druggability database" . Database 2014 (2014).
http://dx.doi.org/10.1093/database/bau035
---------- MLA ----------
Radusky, L., Defelipe, L.A., Lanzarotti, E., Luque, J., Barril, X., Marti, M.A., et al. "TuberQ: A Mycobacterium tuberculosis protein druggability database" . Database, vol. 2014, 2014.
http://dx.doi.org/10.1093/database/bau035
---------- VANCOUVER ----------
Radusky, L., Defelipe, L.A., Lanzarotti, E., Luque, J., Barril, X., Marti, M.A., et al. TuberQ: A Mycobacterium tuberculosis protein druggability database. Database. 2014;2014.
http://dx.doi.org/10.1093/database/bau035