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Referencias:

• Keren, H., Lev-Maor, G., Ast, G., Alternative splicing and evolution: diversification, exon definition and function. (2010) Nat Rev Genet, 11, pp. 345-355
• Nilsen, T.W., Graveley, B.R., Expansion of the eukaryotic proteome by alternative splicing. (2010) Nature, 463, pp. 457-463
• Wang, Z., Burge, C.B., Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. (2008) RNA, 14, pp. 802-813
• Saltzman, A.L., Kim, Y.K., Pan, Q., Fagnani, M.M., Maquat, L.E., Blencowe, B.J., Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. (2008) Mol Cell Biol, 28, pp. 4320-4330
• Pan, Q., Shai, O., Lee, L.J., Frey, B.J., Blencowe, B.J., Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. (2008) Nat Genet, 40, pp. 1413-1415
• Wang, E.T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S.F., Burge, C.B., Alternative isoform regulation in human tissue transcriptomes. (2008) Nature, 456, pp. 470-476
• Srebrow, A., Kornblihtt, A.R., The connection between splicing and cancer. (2006) J Cell Sci, 119 (PART 13), pp. 2635-2641
• Hoskins, A.A., Friedman, L.J., Gallagher, S.S., Crawford, D.J., Anderson, E.G., Wombacher, R., Ramirez, N., Moore, M.J., Ordered and dynamic assembly of single spliceosomes. (2011) Science, 331, pp. 1289-1295
• Wahl, M.C., Will, C.L., Luhrmann, R., The spliceosome: design principles of a dynamic RNP machine. (2009) Cell, 136, pp. 701-718
• Hegele, A., Kamburov, A., Grossmann, A., Sourlis, C., Wowro, S., Weimann, M., Will, C.L., Stelzl, U., Dynamic protein-protein interaction wiring of the human spliceosome. (2012) Mol Cell, 45, pp. 567-580
• Beckmann, J.S., Trifonov, E.N., Splice junctions follow a 205-base ladder. (1991) Proc Natl Acad Sci U S A, 88, pp. 2380-2383
• Hawkins, J.D., A survey on intron and exon lengths. (1988) Nucleic Acids Res, 16, pp. 9893-9908
• Berget, S.M., Exon recognition in vertebrate splicing. (1995) J Biol Chem, 270, pp. 2411-2414
• Fox-Walsh, K.L., Dou, Y., Lam, B.J., Hung, S.P., Baldi, P.F., Hertel, K.J., The architecture of pre-mRNAs affects mechanisms of splice-site pairing. (2005) Proc Natl Acad Sci U S A, 102, pp. 16176-16181
• Fox-Walsh, K.L., Hertel, K.J., Splice-site pairing is an intrinsically high fidelity process. (2009) Proc Natl Acad Sci U S A, 106, pp. 1766-1771
• Witten, J.T., Ule, J., Understanding splicing regulation through RNA splicing maps. (2011) Trends Genet, 27, pp. 89-97
• Barash, Y., Calarco, J.A., Gao, W., Pan, Q., Wang, X., Shai, O., Blencowe, B.J., Frey, B.J., Deciphering the splicing code. (2010) Nature, 465, pp. 53-59
• Licatalosi, D.D., Mele, A., Fak, J.J., Ule, J., Kayikci, M., Chi, S.W., Clark, T.A., Wang, X., HITS-CLIP yields genome-wide insights into brain alternative RNA processing. (2008) Nature, 456, pp. 464-469
• Schones, D.E., Cui, K., Cuddapah, S., Roh, T.Y., Barski, A., Wang, Z., Wei, G., Zhao, K., Dynamic regulation of nucleosome positioning in the human genome. (2008) Cell, 132, pp. 887-898
• Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Zhao, K., High-resolution profiling of histone methylations in the human genome. (2007) Cell, 129, pp. 823-837
• Chodavarapu, R.K., Feng, S., Bernatavichute, Y.V., Chen, P.Y., Stroud, H., Yu, Y., Hetzel, J.A., Cokus, S.J., Relationship between nucleosome positioning and DNA methylation. (2010) Nature, 466, pp. 388-392
• Beyer, A.L., Osheim, Y.N., Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. (1988) Genes Dev, 2, pp. 754-765
• Pandya-Jones, A., Black, D.L., Co-transcriptional splicing of constitutive and alternative exons. (2009) RNA, 15, pp. 1896-1908
• Bauren, G., Wieslander, L., Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription. (1994) Cell, 76, pp. 183-192
• de la Mata, M., Lafaille, C., Kornblihtt, A.R., First come, first served revisited: factors affecting the same alternative splicing event have different effects on the relative rates of intron removal. (2010) RNA, 16, pp. 904-912
• Tardiff, D.F., Lacadie, S.A., Rosbash, M., A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. (2006) Mol Cell, 24, pp. 917-929
• Gornemann, J., Kotovic, K.M., Hujer, K., Neugebauer, K.M., Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. (2005) Mol Cell, 19, pp. 53-63
• Kotovic, K.M., Lockshon, D., Boric, L., Neugebauer, K.M., Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast. (2003) Mol Cell Biol, 23, pp. 5768-5779
• Lacadie, S.A., Rosbash, M., Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. (2005) Mol Cell, 19, pp. 65-75
• Roberts, G.C., Gooding, C., Mak, H.Y., Proudfoot, N.J., Smith, C.W., Co-transcriptional commitment to alternative splice site selection. (1998) Nucleic Acids Res, 26, pp. 5568-5572
• Listerman, I., Sapra, A.K., Neugebauer, K.M., Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells. (2006) Nat Struct Mol Biol, 13, pp. 815-822
• Vargas, D.Y., Shah, K., Batish, M., Levandoski, M., Sinha, S., Marras, S.A., Schedl, P., Tyagi, S., Single-molecule imaging of transcriptionally coupled and uncoupled splicing. (2011) Cell, 147, pp. 1054-1065
• Kornblihtt, A.R., de la Mata, M., Fededa, J.P., Munoz, M.J., Nogues, G., Multiple links between transcription and splicing. (2004) RNA, 10, pp. 1489-1498
• Moore, M.J., Proudfoot, N.J., Pre-mRNA processing reaches back to transcription and ahead to translation. (2009) Cell, 136, pp. 688-700
• Perales, R., Bentley, D., "Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions. (2009) Mol Cell, 36, pp. 178-191
• Munoz, M.J., de la Mata, M., Kornblihtt, A.R., The carboxy terminal domain of RNA polymerase II and alternative splicing. (2010) Trends Biochem Sci, 35, pp. 497-504
• Cramer, P., Caceres, J.F., Cazalla, D., Kadener, S., Muro, A.F., Baralle, F.E., Kornblihtt, A.R., Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. (1999) Mol Cell, 4, pp. 251-258
• de la Mata, M., Kornblihtt, A.R., RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. (2006) Nat Struct Mol Biol, 13, pp. 973-980
• Misteli, T., Spector, D.L., RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. (1999) Mol Cell, 3, pp. 697-705
• Das, R., Yu, J., Zhang, Z., Gygi, M.P., Krainer, A.R., Gygi, S.P., Reed, R., SR proteins function in coupling RNAP II transcription to pre-mRNA splicing. (2007) Mol Cell, 26, pp. 867-881
• Huang, Y., Li, W., Yao, X., Lin, Q.J., Yin, J.W., Liang, Y., Heiner, M., Wang, G., Mediator complex regulates alternative mRNA processing via the MED23 subunit. (2012) Mol Cell, 45, pp. 459-469
• Auboeuf, D., Honig, A., Berget, S.M., O'Malley, B.W., Coordinate regulation of transcription and splicing by steroid receptor coregulators. (2002) Science, 298, pp. 416-419
• Auboeuf, D., Dowhan, D.H., Kang, Y.K., Larkin, K., Lee, J.W., Berget, S.M., O'Malley, B.W., Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes. (2004) Proc Natl Acad Sci U S A, 101, pp. 2270-2274
• Fong, Y.W., Zhou, Q., Stimulatory effect of splicing factors on transcriptional elongation. (2001) Nature, 414, pp. 929-933
• Lin, S., Coutinho-Mansfield, G., Wang, D., Pandit, S., Fu, X.D., The splicing factor SC35 has an active role in transcriptional elongation. (2008) Nat Struct Mol Biol, 15, pp. 819-826
• Alexander, R.D., Innocente, S.A., Barrass, J.D., Beggs, J.D., Splicing-dependent RNA polymerase pausing in yeast. (2010) Mol Cell, 40, pp. 582-593
• Carrillo Oesterreich, F., Preibisch, S., Neugebauer, K.M., Global analysis of nascent RNA reveals transcriptional pausing in terminal exons. (2010) Mol Cell, 40, pp. 571-581
• Martins, S.B., Rino, J., Carvalho, T., Carvalho, C., Yoshida, M., Klose, J.M., de Almeida, S.F., Carmo-Fonseca, M., Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes. (2011) Nat Struct Mol Biol, 18, pp. 1115-1123
• Ip, J.Y., Schmidt, D., Pan, Q., Ramani, A.K., Fraser, A.G., Odom, D.T., Blencowe, B.J., Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation. (2011) Genome Res, 21, pp. 390-401
• Nogues, G., Kadener, S., Cramer, P., Bentley, D., Kornblihtt, A.R., Transcriptional activators differ in their abilities to control alternative splicing. (2002) J Biol Chem, 277, pp. 43110-43114
• Kadener, S., Cramer, P., Nogues, G., Cazalla, D., de la Mata, M., Fededa, J.P., Werbajh, S.E., Kornblihtt, A.R., Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing. (2001) EMBO J, 20, pp. 5759-5768
• de la Mata, M., Alonso, C.R., Kadener, S., Fededa, J.P., Blaustein, M., Pelisch, F., Cramer, P., Kornblihtt, A.R., A slow RNA polymerase II affects alternative splicing in vivo. (2003) Mol Cell, 12, pp. 525-532
• Muñoz, M.J., Perez Santangelo, M.S., Paronetto, M.P., de la Mata, M., Pelisch, F., Boireau, S., Glover-Cutter, K., Lozano, J.J., DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. (2009) Cell, 137, pp. 708-720
• Berger, S.L., The complex language of chromatin regulation during transcription. (2007) Nature, 447, pp. 407-412
• Li, B., Carey, M., Workman, J.L., The role of chromatin during transcription. (2007) Cell, 128, pp. 707-719
• Hodges, C., Bintu, L., Lubkowska, L., Kashlev, M., Bustamante, C., Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II. (2009) Science, 325, pp. 626-628
• Petesch, S.J., Lis, J.T., Overcoming the nucleosome barrier during transcript elongation. (2012) Trends Genet, 28, pp. 285-294
• Kouzarides, T., Chromatin modifications and their function. (2007) Cell, 128, pp. 693-705
• Smallwood, A., Esteve, P.O., Pradhan, S., Carey, M., Functional cooperation between HP1 and DNMT1 mediates gene silencing. (2007) Genes Dev, 21, pp. 1169-1178
• Ernst, J., Kellis, M., Discovery and characterization of chromatin states for systematic annotation of the human genome. (2010) Nat Biotechnol, 28, pp. 817-825
• Schor, I.E., Rascovan, N., Pelisch, F., Allo, M., Kornblihtt, A.R., Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. (2009) Proc Natl Acad Sci U S A, 106, pp. 4325-4330
• Zhou, H.L., Hinman, M.N., Barron, V.A., Geng, C., Zhou, G., Luo, G., Siegel, R.E., Lou, H., Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. (2011) Proc Natl Acad Sci U S A, 108, pp. E627-E635
• Allo, M., Buggiano, V., Fededa, J.P., Petrillo, E., Schor, I., de la Mata, M., Agirre, E., Elela, S.A., Control of alternative splicing through siRNA-mediated transcriptional gene silencing. (2009) Nat Struct Mol Biol, 16, pp. 717-724
• Saint-Andre, V., Batsche, E., Rachez, C., Muchardt, C., Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons. (2011) Nat Struct Mol Biol, 18, pp. 337-344
• Sims, R.J., Millhouse, S., Chen, C.F., Lewis, B.A., Erdjument-Bromage, H., Tempst, P., Manley, J.L., Reinberg, D., Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007) Mol Cell, 28, pp. 665-676
• Luco, R.F., Pan, Q., Tominaga, K., Blencowe, B.J., Pereira-Smith, O.M., Misteli, T., Regulation of alternative splicing by histone modifications. (2010) Science, 327, pp. 996-1000
• Hodges, E., Smith, A.D., Kendall, J., Xuan, Z., Ravi, K., Rooks, M., Zhang, M.Q., Brizuela, L., High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. (2009) Genome Res, 19, pp. 1593-1605
• Fernandes de Almeida, S., Grosso, A.R., Koch, F., Fenouil, R., Carvalho, S., Andrade, J., Levezinho, H., Gut, I., Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36. (2011) Nat Struct Mol Biol, 18, pp. 977-983
• Kim, S., Kim, H., Fong, N., Erickson, B., Bentley, D.L., Pre-mRNA splicing is a determinant of histone H3K36 methylation. (2011) Proc Natl Acad Sci U S A, 108, pp. 13564-13569
• Andersson, R., Enroth, S., Rada-Iglesias, A., Wadelius, C., Komorowski, J., Nucleosomes are well positioned in exons and carry characteristic histone modifications. (2009) Genome Res, 19, pp. 1732-1741
• Schwartz, S., Meshorer, E., Ast, G., Chromatin organization marks exon-intron structure. (2009) Nat Struct Mol Biol, 16, pp. 990-995
• Spies, N., Nielsen, C.B., Padgett, R.A., Burge, C.B., Biased chromatin signatures around polyadenylation sites and exons. (2009) Mol Cell, 36, pp. 245-254
• Tilgner, H., Nikolaou, C., Althammer, S., Sammeth, M., Beato, M., Valcarcel, J., Guigo, R., Nucleosome positioning as a determinant of exon recognition. (2009) Nat Struct Mol Biol, 16, pp. 996-1001
• Kornblihtt, A.R., Schor, I.E., Allo, M., Blencowe, B.J., When chromatin meets splicing. (2009) Nat Struct Mol Biol, 16, pp. 902-903
• Kaplan, N., Moore, I.K., Fondufe-Mittendorf, Y., Gossett, A.J., Tillo, D., Field, Y., LeProust, E.M., Widom, J., The DNA-encoded nucleosome organization of a eukaryotic genome. (2009) Nature, 458, pp. 362-366
• Peckham, H.E., Thurman, R.E., Fu, Y., Stamatoyannopoulos, J.A., Noble, W.S., Struhl, K., Weng, Z., Nucleosome positioning signals in genomic DNA. (2007) Genome Res, 17, pp. 1170-1177
• Schwartz, S., Ast, G., Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing. (2010) EMBO J, 29, pp. 1629-1636
• Kolasinska-Zwierz, P., Down, T., Latorre, I., Liu, T., Liu, X.S., Ahringer, J., Differential chromatin marking of introns and expressed exons by H3K36me3. (2009) Nat Genet, 41, pp. 376-381
• Yoh, S.M., Lucas, J.S., Jones, K.A., The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. (2008) Genes Dev, 22, pp. 3422-3434
• Tong, W., Kulaeva, O.I., Clark, D.J., Lutter, L.C., Topological analysis of plasmid chromatin from yeast and mammalian cells. (2006) J Mol Biol, 361, pp. 813-822
• Zhu, H., Hasman, R.A., Barron, V.A., Luo, G., Lou, H., A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. (2006) Mol Biol Cell, 17, pp. 5105-5114
• Morris, K.V., Chan, S.W., Jacobsen, S.E., Looney, D.J., Small interfering RNA-induced transcriptional gene silencing in human cells. (2004) Science, 305, pp. 1289-1292
• Janowski, B.A., Huffman, K.E., Schwartz, J.C., Ram, R., Nordsell, R., Shames, D.S., Minna, J.D., Corey, D.R., Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. (2006) Nat Struct Mol Biol, 13, pp. 787-792
• Jacquier, A., The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. (2009) Nat Rev Genet, 10, pp. 833-844
• Muchardt, C., Guilleme, M., Seeler, J.S., Trouche, D., Dejean, A., Yaniv, M., Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α (2002) EMBO Rep, 3, pp. 975-981
• Shukla, S., Kavak, E., Gregory, M., Imashimizu, M., Shutinoski, B., Kashlev, M., Oberdoerffer, P., Oberdoerffer, S., CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011) Nature, 479, pp. 74-79
• Phillips, J.E., Corces, V.G., CTCF: master weaver of the genome. (2009) Cell, 137, pp. 1194-1211
• Batsche, E., Yaniv, M., Muchardt, C., The human SWI/SNF subunit Brm is a regulator of alternative splicing. (2006) Nat Struct Mol Biol, 13, pp. 22-29
• Martinez, E., Palhan, V.B., Tjernberg, A., Lymar, E.S., Gamper, A.M., Kundu, T.K., Chait, B.T., Roeder, R.G., Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (2001) Mol Cell Biol, 21, pp. 6782-6795
• Loomis, R.J., Naoe, Y., Parker, J.B., Savic, V., Bozovsky, M.R., Macfarlan, T., Manley, J.L., Chakravarti, D., Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. (2009) Mol Cell, 33, pp. 450-461
• Margueron, R., Reinberg, D., Chromatin structure and the inheritance of epigenetic information. (2010) Nat Rev Genet, 11, pp. 285-296

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