Artículo

Chaves-Ferreira, M.; Krenn, G.; Vasseur, F.; Barinov, A.; Gonçalves, P.; Azogui, O.; Cumano, A.; Li, Z.; Pellegrini, S.; Rocha, B.; Laderach, D. "The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells" (2016) Biology Direct. 11(1)
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Abstract:

Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis. © 2016 Chaves-Ferreira et al.

Registro:

Documento: Artículo
Título:The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
Autor:Chaves-Ferreira, M.; Krenn, G.; Vasseur, F.; Barinov, A.; Gonçalves, P.; Azogui, O.; Cumano, A.; Li, Z.; Pellegrini, S.; Rocha, B.; Laderach, D.
Filiación:INSERM, U 1020, U1151 - CNRS, UMR 8253, Institut Necker Enfants Malades, Faculté de Médecine Paris Descartes, 25, Rue du Dr Roux, Paris, Cedex 15, France
Institut Pasteur, 25, Rue du Dr Roux, Paris, Cedex 15, France
Instituto de Medicina Molecular, Avenida Prof. Egas Moniz, Lisbon, 1649-028, Portugal
Universidad de Buenos Aires, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Intendente Guiraldes 2160, Buenos Aires, C1428EGA, Argentina
Palabras clave:Cell cycle; D cyclins; Hematopoiesis; Ccnd1 protein, mouse; Ccnd2 protein, mouse; Ccnd3 protein, mouse; cyclin D1; cyclin D2; cyclin D3; animal; cell differentiation; cell division; genetics; hematopoiesis; metabolism; mouse; transgenic mouse; Animals; Cell Differentiation; Cell Division; Cyclin D1; Cyclin D2; Cyclin D3; Hematopoiesis; Mice; Mice, Transgenic
Año:2016
Volumen:11
Número:1
DOI: http://dx.doi.org/10.1186/s13062-016-0122-9
Título revista:Biology Direct
Título revista abreviado:Biol. Direct
ISSN:17456150
CAS:Ccnd1 protein, mouse; Ccnd2 protein, mouse; Ccnd3 protein, mouse; Cyclin D1; Cyclin D2; Cyclin D3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17456150_v11_n1_p_ChavesFerreira

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Citas:

---------- APA ----------
Chaves-Ferreira, M., Krenn, G., Vasseur, F., Barinov, A., Gonçalves, P., Azogui, O., Cumano, A.,..., Laderach, D. (2016) . The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells. Biology Direct, 11(1).
http://dx.doi.org/10.1186/s13062-016-0122-9
---------- CHICAGO ----------
Chaves-Ferreira, M., Krenn, G., Vasseur, F., Barinov, A., Gonçalves, P., Azogui, O., et al. "The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells" . Biology Direct 11, no. 1 (2016).
http://dx.doi.org/10.1186/s13062-016-0122-9
---------- MLA ----------
Chaves-Ferreira, M., Krenn, G., Vasseur, F., Barinov, A., Gonçalves, P., Azogui, O., et al. "The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells" . Biology Direct, vol. 11, no. 1, 2016.
http://dx.doi.org/10.1186/s13062-016-0122-9
---------- VANCOUVER ----------
Chaves-Ferreira, M., Krenn, G., Vasseur, F., Barinov, A., Gonçalves, P., Azogui, O., et al. The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells. Biol. Direct. 2016;11(1).
http://dx.doi.org/10.1186/s13062-016-0122-9