Artículo

Lillo, C.R.; Natalia Calienni, M.; Gorojod, R.M.; Rivas Aiello, M.B.; Rodriguez Sartori, D.; Prieto, M.J.; Alonso, S.D.V.; Kotler, M.L.; Gonzalez, M.C.; Montanari, J. "Toward biomedical application of amino-functionalized silicon nanoparticles" (2018) Nanomedicine. 13(11):1349-1370
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Abstract:

Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs. © 2018 Future Medicine Ltd.

Registro:

Documento: Artículo
Título:Toward biomedical application of amino-functionalized silicon nanoparticles
Autor:Lillo, C.R.; Natalia Calienni, M.; Gorojod, R.M.; Rivas Aiello, M.B.; Rodriguez Sartori, D.; Prieto, M.J.; Alonso, S.D.V.; Kotler, M.L.; Gonzalez, M.C.; Montanari, J.
Filiación:Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CCT-La Plata-CONICET, Universidad Nacional de la Plata, La Plata, 1900, Argentina
Instituto de Nanosistemas (INS), Universidad Nacional de San Martin, San-Martín, 1650, Argentina
Laboratorio de Biomembranas-GBEyB (IMBICE, CCT-La Plata, CONICET), Departamento de Ciencia y Tecnologiá, Universidad Nacional de Quilmes, Bernal, 1876, Argentina
CONICET-Universidad de Buenos Aires. Instituto de Quimica Biologica Ciencias Exactas y Naturales, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina, Ciudad Autónoma de Buenos Aires, 1428, Argentina
Palabras clave:PDT; radiotherapy; silicon nanoparticles; skin penetration; ultradeformable liposomes; zebrafish; amino functionalized silicon nanoparticle; liposome; nanoparticle; photosensitizing agent; reactive oxygen metabolite; unclassified drug; liposome; nanoparticle; photosensitizing agent; silicon; adult; animal cell; Article; cell viability; controlled study; cytotoxicity; drug delivery system; embryo; epidermis; female; human; human cell; human tissue; in vitro study; in vivo study; incubation time; nanoencapsulation; nonhuman; particle size; photodynamic therapy; priority journal; radiotherapy; rat; skin penetration; tumor cell line; zebra fish; animal; cell survival; chemistry; drug delivery system; drug effect; growth, development and aging; metabolism; photochemotherapy; Animals; Cell Survival; Drug Delivery Systems; Humans; Liposomes; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Silicon; Zebrafish
Año:2018
Volumen:13
Número:11
Página de inicio:1349
Página de fin:1370
DOI: http://dx.doi.org/10.2217/nnm-2018-0010
Título revista:Nanomedicine
Título revista abreviado:Nanomedicine
ISSN:17435889
CAS:silicon, 7440-21-3; Liposomes; Photosensitizing Agents; Reactive Oxygen Species; Silicon
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17435889_v13_n11_p1349_Lillo

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Citas:

---------- APA ----------
Lillo, C.R., Natalia Calienni, M., Gorojod, R.M., Rivas Aiello, M.B., Rodriguez Sartori, D., Prieto, M.J., Alonso, S.D.V.,..., Montanari, J. (2018) . Toward biomedical application of amino-functionalized silicon nanoparticles. Nanomedicine, 13(11), 1349-1370.
http://dx.doi.org/10.2217/nnm-2018-0010
---------- CHICAGO ----------
Lillo, C.R., Natalia Calienni, M., Gorojod, R.M., Rivas Aiello, M.B., Rodriguez Sartori, D., Prieto, M.J., et al. "Toward biomedical application of amino-functionalized silicon nanoparticles" . Nanomedicine 13, no. 11 (2018) : 1349-1370.
http://dx.doi.org/10.2217/nnm-2018-0010
---------- MLA ----------
Lillo, C.R., Natalia Calienni, M., Gorojod, R.M., Rivas Aiello, M.B., Rodriguez Sartori, D., Prieto, M.J., et al. "Toward biomedical application of amino-functionalized silicon nanoparticles" . Nanomedicine, vol. 13, no. 11, 2018, pp. 1349-1370.
http://dx.doi.org/10.2217/nnm-2018-0010
---------- VANCOUVER ----------
Lillo, C.R., Natalia Calienni, M., Gorojod, R.M., Rivas Aiello, M.B., Rodriguez Sartori, D., Prieto, M.J., et al. Toward biomedical application of amino-functionalized silicon nanoparticles. Nanomedicine. 2018;13(11):1349-1370.
http://dx.doi.org/10.2217/nnm-2018-0010