Conferencia
Abstract:
Electrochemotherapy (ECT), a medical treatment widely used in human tumor treatment, consists in the administration of bleomycin either systemically or locally followed by the application of an electric field. This procedure increases the toxicity of the bleomycin by 1000 fold in the treated area with an objective response rate of around 80%. Despite its success related to efficiency, low cost and minimum side effects, there is still a 20% of cases in which the ECT treatment is not responding. This could be ascribed to the fact that bleomycin, administered in the preferred way, that is, systemically for large tumors, is not properly reaching the whole tumor mass. The main cause is poor tumor vascularization, in which case local administration could cover areas unreachable with systemic administration. To address this problem here we propose the combined administration of bleomycin, systemic and locally, using companion animals as models for ECT tumor treating. Accordingly, we selected 7 canine and 2 feline patients with a single tumor with poor or no response to ECT, and then we repeat the treatment with ECT but now with a combined administration of bleomycin, systemic and local. The results show, according to an evaluation using the WHO criteria of tumor response, that from the 9 cases, 5 achieved a Complete Response, 3 a Partial Response, and 1 a Stable Disease after 30 days from the combined treatment date. In conclusion, the combined administration of bleomycin, systemic and local, in ECT could provide a good response in tumors that previously showed an unsatisfactory response. It is expected that these results could hopefully increase ECT efficiency. © Springer Science+Business Media Singapore 2016.
Registro:
| Documento: | Conferencia |
| Título: | Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local |
| Autor: | Maglietti, F.; Tellado, M.; Olaiz, N.; Michinski, S.; Marshall, G.; Kramar P.; Jarm T. |
| Filiación: | Laboratorio de Sistemas Complejos, Dpto de Computación e Instituto de Física del Plasma, Universidad de Buenos Aires, Buenos Aires, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina Universidad de Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | Bleomycin; Combined; Electrochemotherapy; Local systemic; Efficiency; Electric fields; Environmental technology; Patient treatment; Peptides; Bleomycins; Combined; Combined treatment; Complete response; Electrochemotherapy; Local systemic; Systemic administration; Tumor vascularization; Tumors |
| Año: | 2016 |
| Volumen: | 53 |
| Página de inicio: | 445 |
| Página de fin: | 448 |
| DOI: | http://dx.doi.org/10.1007/978-981-287-817-5_97 |
| Título revista: | 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 |
| Título revista abreviado: | IFMBE Proc. |
| ISSN: | 16800737 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16800737_v53_n_p445_Maglietti |
Referencias:
- Yarmush, M.L., Golberg, A., Sersa, G., Kotnikv, T., Miklavcic, D., Electroporation-based technologies for medicine: Principles, applications, and challenges (2014) Annual Review of Biomedical Engineering, 16, pp. 295-320
- Sersa, G., Garbay, J.R., Gehl, J., Collins, C., Snoj, M., Electrochemotherapy - a simple, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures for Electrochemotherapy) study. 11 (2006) Eur J Cancer Supp, 4, pp. 3-13
- Mali, B., Jarm, T., Snoj, M., Sersa, G., Miklavcic, D., Antitumor effectiveness of electrochemotherapy: A systematic review and metaanalysis (2013) Eur J Sur Oncol, 39, pp. 4-16
- Kumar, V., Abbas, A., Neoplasia, A.J., Robbins Basic Pathology (2013) Philadelphia: Elsevier, 5, pp. 191-192
- Tozon, N., Cemazar, M., Electrochemotherapy in veterinary medicine (2007) IFMBE Proceedings, 16, pp. 586-588
- Spugnini, E.P., Baldi, F., Mellone, P., Feroce, F., D'avino, A., Bonetto, F., Vincenzi, B., Baldi, A., Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: Preclinical data for the standardization of this treatment in pets and humans (2007) Journal of Translational Medicine, 5 (48)
- London, C.A., (2010) Cancer Research, , Spontaneous cancer in dogs: Opportunities for preclinical evaluation of novel therapies. Clinical Cancer Research
- Vail, D.M., Macewen, E.G., Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer. 18 (2000) Cancer Invest, 8, pp. 781-792
- Mir, L., Gehl, J., Sersa, G., Collins, C., Garbay, J.M., Billard, V., Geertsen, P., Marty, M., Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator by means of invasive or non-invasive electrodes (2006) Eur J Cancer Supp, 4, pp. 14-25
- (1979) WHO Handbook for Reporting Results of Cancer Treatment, , Geneva: WHO
- Jaroszeski, M.J., Gilbert, R., Perrott, R., Heller, R., Enhanced effects of multiple treatment electrochemotherapy (1996) Melanoma Research, 6, pp. 427-433A4 - Elea Vertriebs- und Vermarktungsgesellschaft mbH; Electroblate, Inc.; Etal; IGEA S.p.A.; Inovio Pharmaceuticals, Inc.; OncoSec Medical, Inc.
Citas:
---------- APA ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G., Kramar P. & Jarm T. (2016) . Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, 53, 445-448.http://dx.doi.org/10.1007/978-981-287-817-5_97
---------- CHICAGO ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G., Kramar P., et al. "Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 53 (2016) : 445-448.http://dx.doi.org/10.1007/978-981-287-817-5_97
---------- MLA ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G., Kramar P., et al. "Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, vol. 53, 2016, pp. 445-448.http://dx.doi.org/10.1007/978-981-287-817-5_97
---------- VANCOUVER ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G., Kramar P., et al. Electrochemotherapy in non-satisfactory responding tumors in vet patients: Combined administration of bleomycin, systemic and local. IFMBE Proc. 2016;53:445-448.http://dx.doi.org/10.1007/978-981-287-817-5_97
