Conferencia
Abstract:
The electrochemical treatment (ECT) of solid tumors is an electropermeabilization technique firmly established and widely used. In ECT protocols, pulse intensity as well as tissue electric conductivity are of utmost importance for assessing the final electropermeabilized area. Present ECT mathematical modeling based on the solution of the nonlinear Laplace equation for the electric field with a conductivity coefficient depending on the electric field and the temperature have greatly contributed to ECT protocol optimization. However, experimental results from literature report that a succession of pulses may increase tissue electric conductivity and the extent of tissue permeabilization, a phenomenon that present models fail to describe. Here we present new insights of a recently introduced ECT theoretical model that takes into account the effect of pulse addition on tissue electric conductivity. The model describes the electric field with the nonlinear Laplace equation with a conductivity coefficient depending on the electric field, the temperature and the quantity of pulses applied. ECT theoretical predictions show that the rise in the electric current density during the addition of pulses is due solely to an increment in the tissue electric conductivity with no significant changes in the electric field. A potential consequence of these results is that, under certain conditions, it would be possible to obtain larger electropermeabilized areas with the same pulse amplitude simply by increasing the number of pulses. The theoretical implications of this new model lead to a more realistic description of the EP phenomenon, hopefully providing more accurate predictions of ECT treatment outcomes. © Springer Science+Business Media Singapore 2016.
Registro:
| Documento: | Conferencia |
| Título: | Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity |
| Autor: | Suárez, C.A.; Soba, A.; Maglietti, F.; Olaiz, N.; Marshall, G.; Kramar P.; Jarm T. |
| Filiación: | Laboratorio de Sistemas Complejos (LSC), Departamento de Computación (DC) and Instituto de Física del Plasma (INFIP), CONICET, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina Centro de Simulación Computacional, CONICET y Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina |
| Palabras clave: | Electric conductivity; Electropermeabilization; Electroporation; Mathematical modeling; Pulse addition; Electric conductivity; Electric conductivity measurement; Electric fields; Environmental technology; Integrodifferential equations; Laplace equation; Laplace transforms; Mathematical models; Nonlinear equations; Conductivity coefficient; Electrochemical treatments; Electropermeabilization; Electroporation; Protocol optimization; Pulse addition; Theoretical modeling; Tissue permeabilization; Tissue |
| Año: | 2016 |
| Volumen: | 53 |
| Página de inicio: | 215 |
| Página de fin: | 218 |
| DOI: | http://dx.doi.org/10.1007/978-981-287-817-5_48 |
| Título revista: | 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 |
| Título revista abreviado: | IFMBE Proc. |
| ISSN: | 16800737 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16800737_v53_n_p215_Suarez |
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Citas:
---------- APA ----------
Suárez, C.A., Soba, A., Maglietti, F., Olaiz, N., Marshall, G., Kramar P. & Jarm T. (2016) . Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, 53, 215-218.http://dx.doi.org/10.1007/978-981-287-817-5_48
---------- CHICAGO ----------
Suárez, C.A., Soba, A., Maglietti, F., Olaiz, N., Marshall, G., Kramar P., et al. "Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 53 (2016) : 215-218.http://dx.doi.org/10.1007/978-981-287-817-5_48
---------- MLA ----------
Suárez, C.A., Soba, A., Maglietti, F., Olaiz, N., Marshall, G., Kramar P., et al. "Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, vol. 53, 2016, pp. 215-218.http://dx.doi.org/10.1007/978-981-287-817-5_48
---------- VANCOUVER ----------
Suárez, C.A., Soba, A., Maglietti, F., Olaiz, N., Marshall, G., Kramar P., et al. Effects of pulse addition in electropermeabilization: Theoretical insights on the electric conductivity. IFMBE Proc. 2016;53:215-218.http://dx.doi.org/10.1007/978-981-287-817-5_48
