Navegar

Colección

Datos Estadísticas

Conferencia

Luján, E.; Schinca, H.; Olaiz, N.; Urquiza, S.; Molina, F.V.; Turjanski, P.; Marshall, G.; Kramar P.; Jarm T. "Electrolytic ablation dose planning methodology" (2016) 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015. 53:101-104
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Electrolytic ablation (EA), a medical treatment increasingly used in solid tumor ablation, consists in the passage of a low direct electric current through two or more electrodes inserted in the tissue thus inducing pH fronts that destroys the tumor. The combined use of EA with a recently introduced one-probe two electrode device (OPTED) results in a minimally invasive tissue ablation technique. Despite its success related to low cost and minimum side effects, EA has drawbacks such as the difficulty in determining the current and time needed to assure total tumor ablation while avoiding healthy tissue intrusion. Here we introduce a realistic dose planning methodology in terms of the coulomb dosage administered and the associated pH tracking, that predicts an optimal EA/OPTED protocol treatment for a given tumor size, that is, the current and exposition time necessary to succeed in eliminating all the tumor mass while minimizing healthy tissue damage. © Springer Science+Business Media Singapore 2016.

Registro:

Documento: Conferencia
Título:Electrolytic ablation dose planning methodology
Autor:Luján, E.; Schinca, H.; Olaiz, N.; Urquiza, S.; Molina, F.V.; Turjanski, P.; Marshall, G.; Kramar P.; Jarm T.
Filiación:Laboratorio de Sistemas Complejos, Departamento de Computación e Instituto de Física del Plasma, Universidad de Buenos Aires (UBA) y Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Instituto de Química Física de los Materiales, Medio Ambiente y Energía, Departamento de Química, Universidad de Buenos Aires (UBA), Argentina
Grupo de Ingeniería Asistida por Computadora, Departamento de Mecánica, Universidad Nacional de Mar del Plata (UNMDP), Buenos Aires, Argentina
Palabras clave:Electrochemical treatment; Electrolytic ablation; In silico model; In vitro model; pH front tracking; Tumors; Ablation; Electric fields; Electrodes; Environmental technology; Tumors; Direct electric currents; Electrochemical treatments; Front tracking; In-silico models; In-vitro models; Medical treatment; Minimally invasive; Tissue ablations; Tissue
Año:2016
Volumen:53
Página de inicio:101
Página de fin:104
DOI: http://dx.doi.org/10.1007/978-981-287-817-5_23
Título revista:1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015
Título revista abreviado:IFMBE Proc.
ISSN:16800737
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16800737_v53_n_p101_Lujan

Referencias:

  • Nordenstrom, B., Preliminary clinical trials of electrophoretic ionization in the treatment of malignant tumours (1978) IRCS Med. Sc, 6, p. 537
  • Xin, Y.L., Xue, F., Ge, B., Zhao, F., Shi, B., Zhang, W., Electrochemical treatment of lung cancer (1997) Bioelectromagnetics, 18, pp. 8-13
  • Miklavcic, D., Fajgelj, A., Sersa, G., Tumour treatment by direct electric current: Electrode material deposition, Bioelectrochem (1994) Bioenerg, 35, pp. 93-97
  • Mir, L.M., Bases and rationale of the electrochemotherapy (2006) European Journal of Cancer Supplements, 4 (11), pp. 38-44
  • Mali, B., Jarm, T., Snoj, M., Sersa, G., Miklavcic, D., Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis (2013) European Journal of Surgical Oncology, 39, pp. 4-16
  • Mary, P., Narayan, R., Liel, R., Boris, R., Modulating electrolytic tissue ablation with reversible electroporation pulses (2015) TECHNOLOGY, 3, pp. 1-9
  • Nilsson, E., Berendson, J., Fontes, E., (2000) Impact of Chlorine and Acidification in the Electrochemical Treatment of Tumours Journal of Applied Electrochemistry, 30, pp. 1321-1333
  • Olaiz, N., Maglietti, F., Suarez, C., (2010) Electrochemical Treatment of Tumors Using a One-Probe Two-Electrode Device Electrochimicaacta, 55, pp. 6010-6014
  • Colombo, L., Gonzalez, G., Marshall, G., (2007) Ion Transport In Tumors under Electrochemical Treatment: In Vivo, In Vitro and In Silico Modeling Bioelectrochemistry, 71, pp. 223-232
  • Turjanski, P., Olaiz, N., Abou-Adal, P., Suarez, C., Risk, M., Marshall, G., (2009) Ph Front Tracking in the Electrochemical Treatment (Echt) of Tumors: Experiments and Simulations Electrochimicaacta., 54, pp. 6199-6206
  • Lujan, E., Schinca, H., (2015) Optimal Dose-Response Relationship in Electrolytic Ablation of Tumors with a One-Probe-Two-Electrode Device, , (submitted)A4 - Elea Vertriebs- und Vermarktungsgesellschaft mbH; Electroblate, Inc.; Etal; IGEA S.p.A.; Inovio Pharmaceuticals, Inc.; OncoSec Medical, Inc.

Citas:

---------- APA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., Marshall, G.,..., Jarm T. (2016) . Electrolytic ablation dose planning methodology. 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, 53, 101-104.
http://dx.doi.org/10.1007/978-981-287-817-5_23
---------- CHICAGO ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. "Electrolytic ablation dose planning methodology" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015 53 (2016) : 101-104.
http://dx.doi.org/10.1007/978-981-287-817-5_23
---------- MLA ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. "Electrolytic ablation dose planning methodology" . 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food and Environmental Technologies, WC 2015, vol. 53, 2016, pp. 101-104.
http://dx.doi.org/10.1007/978-981-287-817-5_23
---------- VANCOUVER ----------
Luján, E., Schinca, H., Olaiz, N., Urquiza, S., Molina, F.V., Turjanski, P., et al. Electrolytic ablation dose planning methodology. IFMBE Proc. 2016;53:101-104.
http://dx.doi.org/10.1007/978-981-287-817-5_23