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Abstract:

Cardiovascular diseases constitute one of the major reasons of death with high prevalence in the western industrialized societies. Endothelial dysfunction plays a fundamental role in physiopathological mechanisms and it is considered a syndrome with systemic manifestations associated with cardiovascular significant morbidity and mortality. The concept of endothelial dysfunction might spread up to the vessels that irrigate the vascular wall and even more, the bony marrow and the progenitor cells of endothelium. The aim of this project is the implementation of an integral system for real-time processing of pressure, flow, vascular dimension, field of velocity profile and wall shear stress simultaneously (using Doppler velocimetry, computational fluid dynamics, piezoelectric and strain gauge sensors), in order to assess endothelial function. This system will constitute the gold standard of an immediate miniaturization (using bioMems), for evaluating the endothelium capability, in accordance to the development of implantable sensors with capacity of acquisition of additional magnitudes of the whole system, as temperatures, PH and Nitric Oxide. © 2013 Springer.

Registro:

Documento: Conferencia
Título:Abordaje integral para la caracterización in vitro de la dinámica endotelial
Autor:Armentano, R.L.; Pessana, F.M.; Cymberknop, L.J.; Graf, S.; Furfaro, A.
Ciudad:Habana
Filiación:Departamento de Electrónica, Facultad Regional Buenos Aires, Universidad Tecnológica Nacional, Buenos Aires, Argentina
Departamento de Tecnología Electrónica, Facultad de Ingeniería, Ciencias Exactas Y Naturales, Universidad Favaloro Buenos Aires, Buenos Aires, Argentina
Idioma: Español
Palabras clave:bioMems; cardiovascular disease; CFD; doppler velocimetry; endothelial cells; Cardio-vascular disease; Doppler velocimetry; Endothelial dysfunction; Endothelial function; Implantable sensors; Realtime processing; Strain gauge sensors; Velocity profiles; Biomedical engineering; BioMEMS; Computational fluid dynamics; Diseases; Doppler effect; Mica; Nitric oxide; Endothelial cells
Año:2013
Volumen:33 IFMBE
Página de inicio:1126
Página de fin:1129
DOI: http://dx.doi.org/10.1007/978-3-642-21198-0_286
Título revista:IFMBE Proceedings
Título revista abreviado:IFMBE Proc.
ISSN:16800737
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16800737_v33IFMBE_n_p1126_Armentano

Referencias:

  • Bonetti, Endothelial dysfunction: A marker of atherosclerotic risk (2003) Arterioscler Thromb Vasc Biol, 23, pp. 168-175
  • Lerman, A., Intact and altered endothelium in regulation of vasomotion (1992) Circulation, 86 (SUPPL. III), pp. III12-III19
  • Kamiya, A., Togawa, T., Adaptive regulation of wall shear stress to flow change in the canine carotid artery (1980) Am J Physiol, 239 (1), pp. H14-H21
  • Schmidt, M.A., Howe, R.T., Senturia, S.D., Haritonidis, J.H., Design and calibration of a microfabricated floating element shear stress sensor (1988) IEEE Transactions of Electron Devices, ED-35, pp. 750-757
  • Shajii, J., Ng, K.Y., Schmidt, M.A., A microfabricated floating element shear stress sensor using wafer-bonding technology (1992) J. of Microelectromechanicals Systems, pp. 89-94
  • Ai, L., Yu, H., Tabake, W., Paraboschi, A., Yu, F., Kim, E.S., Li, R., Hsiai, T.K., Optimization of intravascular shear stress assessment in vivo (2009) J Biomech, 42 (10), pp. 1429-1437
  • Hsiai, T.K., Cho, S.K., Wong, P.K., Ing, M., Navab, M., Reddy, S., Demer, L.L., Ho, C.M., Bio-MEMS Sensors for Real-Time Shear Stress on Endothelial Cell Dynamics (2002) Proceedings of the Second Joint EMBS/BMES, Houston, TX, USA
  • Naware, M., Rege, A., Genov, R., Stanacevic, M., Cauwenberghs, G., Thakor, N., Integrated Multi-electrode fluidic nitric-oxide sensor and vlsi potentiostat array (2004) Proceedings of the 2004 International Symposium on Circuits and Systems (ISCAS'04)

Citas:

---------- APA ----------
Armentano, R.L., Pessana, F.M., Cymberknop, L.J., Graf, S. & Furfaro, A. (2013) . Abordaje integral para la caracterización in vitro de la dinámica endotelial. IFMBE Proceedings, 33 IFMBE, 1126-1129.
http://dx.doi.org/10.1007/978-3-642-21198-0_286
---------- CHICAGO ----------
Armentano, R.L., Pessana, F.M., Cymberknop, L.J., Graf, S., Furfaro, A. "Abordaje integral para la caracterización in vitro de la dinámica endotelial" . IFMBE Proceedings 33 IFMBE (2013) : 1126-1129.
http://dx.doi.org/10.1007/978-3-642-21198-0_286
---------- MLA ----------
Armentano, R.L., Pessana, F.M., Cymberknop, L.J., Graf, S., Furfaro, A. "Abordaje integral para la caracterización in vitro de la dinámica endotelial" . IFMBE Proceedings, vol. 33 IFMBE, 2013, pp. 1126-1129.
http://dx.doi.org/10.1007/978-3-642-21198-0_286
---------- VANCOUVER ----------
Armentano, R.L., Pessana, F.M., Cymberknop, L.J., Graf, S., Furfaro, A. Abordaje integral para la caracterización in vitro de la dinámica endotelial. IFMBE Proc. 2013;33 IFMBE:1126-1129.
http://dx.doi.org/10.1007/978-3-642-21198-0_286