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Abstract:

There are variable responses to Serotonin Selective Reuptake Inhibitors (SSRIs) among patients treated with this medication. Polymorphisms found in the genes coding for the serotonin transporter (5-HTT) and the serotonin 2A receptor (5-HTR2A) can be used as genetic biomarkers capable of predicting treatment efficacy. The SLC6A4 gene has two polymorphisms: 5-HTTLPR, consisting of an insertion/deletion of 44 bp, and 5-HTTVNTR, characterized by 9, 10 or 12 copies of a region of 16-17 bp. Gene 5-HTR2A presents the 1438 G/A SNP. In order to obtain the allelic and genotypic frequencies of the listed polymorphisms in a sample of the Mar del Plata city population, Argentina; PCR and PCR-RFLP methodologies were applied to genotype the 5-HTTLPR and 5-HTTVNTR polymorphisms and the 1438 G/A SNP in 384 unrelated individuals. Different primers for genotyping were compared.The allelic and genotypic frequencies obtained for polymorphism were the following: 5-HTTLPR polymorphism L/L: 18 %; L/S: 61 %; S/S: 21 % (Freq allelic L: 49 %; S: 51 %) and the 5-HTTVNTR 12/12: 42 %, 12/10: 41 %; 10/10: 17 % (Freq Allelic 10: 37.5 %; 12: 62.5 %). For polymorphism 1438 G/A GA: 47 % GG: 36 %, AA: 17 % (Freq allelic G: 59.5 %; A: 40.5 %). This study will provide useful data for investigations that require the use of these polymorphisms as genetic markers linked to the response to psychoactive drugs in our population. © 2017, Sociedad Argentina de Genetica. All rights reserved.

Registro:

Documento: Artículo
Título:Serotonergic polymorphisms: Allelic and genotypic frequency distribution in the Mar del Plata, Argentina, population and comparison of genotyping methods
Autor:Perez Maturo, J.; Videla, Y.; Di Gerónimo, V.; Quintana, S.
Filiación:Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3350, Mar del Plata, Argentina
Laboratorio de Biología Molecular del Instituto de Análisis Fares Taie, Rivadavia 3331, Mar del Plata, Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rivadavia 1917, Buenos Aires, Argentina
Palabras clave:Pharmacogenetics; Population frequencies for depression; Serotonergic polymorphisms; serotonin receptor; Argentina; Article; controlled study; gene frequency; genotype; human; major clinical study; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism
Año:2017
Volumen:28
Número:1
Página de inicio:41
Página de fin:49
Título revista:BAG - Journal of Basic and Applied Genetics
Título revista abreviado:BAG J. Basic Appl. Genet.
ISSN:16660390
CODEN:BAGAB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v28_n1_p41_PerezMaturo

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Citas:

---------- APA ----------
Perez Maturo, J., Videla, Y., Di Gerónimo, V. & Quintana, S. (2017) . Serotonergic polymorphisms: Allelic and genotypic frequency distribution in the Mar del Plata, Argentina, population and comparison of genotyping methods . BAG - Journal of Basic and Applied Genetics, 28(1), 41-49.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v28_n1_p41_PerezMaturo [ ]
---------- CHICAGO ----------
Perez Maturo, J., Videla, Y., Di Gerónimo, V., Quintana, S. "Serotonergic polymorphisms: Allelic and genotypic frequency distribution in the Mar del Plata, Argentina, population and comparison of genotyping methods " . BAG - Journal of Basic and Applied Genetics 28, no. 1 (2017) : 41-49.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v28_n1_p41_PerezMaturo [ ]
---------- MLA ----------
Perez Maturo, J., Videla, Y., Di Gerónimo, V., Quintana, S. "Serotonergic polymorphisms: Allelic and genotypic frequency distribution in the Mar del Plata, Argentina, population and comparison of genotyping methods " . BAG - Journal of Basic and Applied Genetics, vol. 28, no. 1, 2017, pp. 41-49.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v28_n1_p41_PerezMaturo [ ]
---------- VANCOUVER ----------
Perez Maturo, J., Videla, Y., Di Gerónimo, V., Quintana, S. Serotonergic polymorphisms: Allelic and genotypic frequency distribution in the Mar del Plata, Argentina, population and comparison of genotyping methods . BAG J. Basic Appl. Genet. 2017;28(1):41-49.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v28_n1_p41_PerezMaturo [ ]