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Abstract:

The toxicity and genotoxicity of thiabendazole (TBZ) in its commercial formulation Foldan® was studied in Allium cepa meristematic cells at concentrations ranging between 10 and 250 μg / ml. Our results show that exposure to TBZ induces a significant increase in the frequency of anaphase telophase chromosomal aberrations, micronuclei and binucleated cells at all the concentrations of TBZ assayed. The frequency of anaphase telophase aberrations was observed to reach a plateau at the concentration of 50 μg / ml of TBZ, which could be probably due to TBZ mitotic toxicity manifested at concentrations of 100 and 250 μg / ml. An increase was also observed in the rate of metaphase and anaphase, which was, in turn, indicative of alterations in chromatid segregation. Results from the present study indicate that exposure to TBZ induces toxicity and genotoxicity, both being consistent with mechanisms that interfere with microtubule formation.

Registro:

Documento: Artículo
Título:Cytological and cytogenetic effects induced by thiabendazole on Allium cepa root meristems
Autor:Andrioli, N.B.; Mudry, M.D.
Filiación:Grupo de Investigación en Biología Evolutiva (GIBE), Departamento de Ecología, Genética y Evolución, Universidad de Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Palabras clave:Binucleates; Cytotoxicity; Genotoxicity; Micronuclei; Mitotic index; Thiabendazole; tiabendazole; anaphase; article; cell disruption; chromatid; chromosome aberration; cytotoxicity; genotoxicity; interphase; meristem; metaphase; micronucleus; microtubule assembly; mitosis index; nonhuman; onion; phragmoplast; plant root; prophase; root cell; telophase
Año:2011
Volumen:22
Número:2
Página de inicio:17
Página de fin:23
Título revista:BAG - Journal of Basic and Applied Genetics
Título revista abreviado:BAG J. Basic Appl. Genet.
ISSN:16660390
CODEN:BAGAB
CAS:tiabendazole, 148-79-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v22_n2_p17_Andrioli

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Citas:

---------- APA ----------
Andrioli, N.B. & Mudry, M.D. (2011) . Cytological and cytogenetic effects induced by thiabendazole on Allium cepa root meristems. BAG - Journal of Basic and Applied Genetics, 22(2), 17-23.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v22_n2_p17_Andrioli [ ]
---------- CHICAGO ----------
Andrioli, N.B., Mudry, M.D. "Cytological and cytogenetic effects induced by thiabendazole on Allium cepa root meristems" . BAG - Journal of Basic and Applied Genetics 22, no. 2 (2011) : 17-23.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v22_n2_p17_Andrioli [ ]
---------- MLA ----------
Andrioli, N.B., Mudry, M.D. "Cytological and cytogenetic effects induced by thiabendazole on Allium cepa root meristems" . BAG - Journal of Basic and Applied Genetics, vol. 22, no. 2, 2011, pp. 17-23.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v22_n2_p17_Andrioli [ ]
---------- VANCOUVER ----------
Andrioli, N.B., Mudry, M.D. Cytological and cytogenetic effects induced by thiabendazole on Allium cepa root meristems. BAG J. Basic Appl. Genet. 2011;22(2):17-23.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16660390_v22_n2_p17_Andrioli [ ]